SWCNT 및 MWCNT의 기관내 점적주입 후 폐 계면활성제의 분석

• 영문명: Analysis of Pulmonary Surfactant after Intratracheal Instillation of SWNCT and MWCNT
• 발행기관: 한국환경보건학회
• 저자명: 이병우(Byeongwoo Lee) 서정관(Jungkwan Seo) 심일섭(Ilseob Shim) 엄익춘(Igchun Eom) 김필제(Plije Kim)
• 간행물 정보: 『1. 한국환경보건학회지』제43권 제4호, 273~279쪽, 전체 7쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2017.08.30

영문 초록

Objectives: Carbon nanotubes (CNTs) are next-generation industrial nanoparticles which possess excellent mechanical strength along with good thermal conductivity and electric properties. Given these characteristics, carbon nanotubes are being widely applied in various fields, including research and development. However, concerns have been raised over hazardous properties due to their similar fiber shape to asbestos. Recent studies ave shown that CNTs pose potential hazards which may cause fibrosis and/or lung inflammation similarly to asbestos. Methods: After intratracheal instillation of SWCNTs and MWCNTs to rats, pulmonary surfactant (PS) of the SWCNTs and MWCNTs was measured and analyzed using bronchoalveolar lavage fluid collected from the lung. After a single intratracheal instillation of SWCNTs and MWCNTs, phospholipid predominantly showed a significant increase compared to the control group, while proteins exhibited a significant increase both three days and one week after instillation. Results: As a result of surface tension, MWCNTs showed a significant decrease three days after treatment compared to the control group. In the case of the total cell number three days after instillation, MWCNTs revealed a temporarily significant increase when compared to the control group. For PMN number, when compared to the control group, SWCNTs displayed a significant increase throughout the observation period, while MWCNTs showed a significant increase three days and three months after treatment. Conclusions: After exposure to CNTs, the total cell number and PNT number, which indicate inflammatory response, were significantly increased. Therefore, this study suggests fiber–shaped CNTs may have a harmful effect on the lungs.

목차

I. 서 론

II. 연구내용 및 방법

III. 결 과

IV. 고 찰

V. 결 론

키워드

Intratracheal instillation pulmonary surfactant MWCNT SWCNT surface tension