β-Glucan induces apoptosis the expression of apoptotic factors in human prostate cancer cells

• 발행기관: 한국예방수의학회
• 저자명: Hyun-Woo Kim HongBum Koh
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.37, No.3, 140~145쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2013.09.30

영문 초록

Prostate cancer is a leading cause of death among the aging men. Surgical or radio therapy is effective when the cancer is confined to the prostate gland but once the cancer spreads beyond the pelvis, even chemotherapy and hormonal ablation therapy fails in curing this disease. Our previous studies have shown that β-glucan induces apoptosis in prostate cancer cells. Cellular viability of these cells treated with β-glucan was measured by MTT assay. β-glucan induced dose- and time-dependent inhibition of cell viability in LNCaP cancer cells. In flow cytometry analysis, β-glucan induced dose- and timedependent apoptotic activities in LNCaP cancer cells. In addition, increased of expression caspase-3, caspase-9, Bax, and cytochrome C but decreased of expression Bcl-2 was observed in LNCaP cells treated with β-glucan. These results suggest that β-glucan induces apoptosis in LNCaP human prostate cancer cells mediated mainly through the increased of expression caspase-3, -9, Bax, cytochrome C and decreased of expression Bcl-2.

목차

Introduction

Materials and Methods

Results

Discussion

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References

키워드

β-glucan apoptosis caspase-3 Bcl-2 bax human prostate cancer cells