Chronic Kidney Disease: A Risk Factor for Parkinson’s Disease

• 발행기관: 대한임상노인의학회
• 저자명: Soo Jin Wang Jae Moon Yun Dong Wook Shin Be Long Cho Ki Young Son Sang Hyuck Kim Ji Eun Lee Soo Min Jung A Young Eo Jeong Yean Yun
• 간행물 정보: 『대한임상노인의학회지』대한임상노인의학회지 제18권 제2호, 95~101쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.12.30

영문 초록

Background: This study aims to reveal risk factors of Parkinson’s disease (PD) within Chronic kidney disease (CKD) patients. A retrospective cohort was designed to clarify the association between PD and CKD through survival analysis. Methods: Based on Korea’s National Health Insurance System (NHIS), the subjects were divided into non-CKD patients and newly diagnosed CKD patients between 2003 and 2004. From 2005 to 2013, a 9 years’ surveillance was performed to detect the occurrence of PD. The association between CKD and PD was assessed using survival analysis. Subjects were divided into 4 CKD stages based on the estimated glomerular filtration rate (eGFR): eGFR＜15 (mL/min/1.73 m2), 15 to 29, 30 to 59 and 60 to 89, hazard ratios (HRs) with 95% confidence intervals (CIs) for each stages were assessed. Results: CKD patients with an eGFR less than 15 had unadjusted HR of 2.79 (95% CI=1.25∼6.21, P＜0.05) and adjusted HR of 2.60 (95% CI=1.25∼6.21, P＜0.05) manifesting increased risk of PD. In male patients with eGFR less than 15, the risk was even higher in unadjusted HR of 4.21 (95% CI=1.75∼10.12, P＜0.05) and adjusted HR of 3.71 (95% CI=1.54∼8.91, P＜0.05). However, no significant association was found within female patients. Conclusion: In this study, a statistically significant association between CKD and PD was found. A notable increase in risk was found in male CKD patients with eGFR less than 15. Thus CKD resulting uremia could lead to increased risk of PDs.

목차

Abstract

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

Renal insufficiency Chronic Parkinson disease