알코올 의존 치료를 위한 아캄프로세이트의 임상적 사용

• 영문명: Treatment of Alcohol Dependence with Acamprosate
• 발행기관: 한국중독정신의학회
• 저자명: 이필구(Pil-Goo Lee):이병욱(Byung-Ook Lee) 최문종(Moon-Jong Choi):이충헌(Choong-Heon Lee) 남궁기(Kee Namkoong)
• 간행물 정보: 『중독정신의학』Vol.4, No.1, 3~10쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2000.04.30

영문 초록

Acamprosate (calcium bis acetylhomotaurinate) is a new medication that appears to be clinically useful in the treatment of alcohol dependence. Although it has proved effective in reducing relapse into drinking in clinical trials its exact neurochemical mechanism of action is not clear yet. Evidence is presented that the drug does not act in any of the conventional ways to reduce alcohol intake or psychotropical medication and it is proposed that it may be a novel kind of agent that suppresses craving. On the basis of its known pharmacological effects in pre-clinical studies it is suggested that acamprosate may reduce craving that is associated with conditioned negative withdrawal. Current trends of the prescriptions through European countries show its therapeutic effectiveness and availability. In addition to the potential therapeutic value of acamprosate, the drug may be useful because work directed toward understanding its mechanism of action may shed light on some of the fundamental processes that constitute alcohol abuse and relapse in weaned alcohol dependent patients.

키워드

Alcohol dependence Acamprosate Clinical guideline