니코틴 의존자에서 인지행동 단독치료와 Naltrexone 추가치료 간의 흡연행동 비교

• 영문명: Comparision of Smoking Behavior Change between Naltrexone Add-On Therapy and Cognitive Behavioral Therapy Alone in Nicotine Dependence
• 발행기관: 한국중독정신의학회
• 저자명: 성종호(Jong-Ho Sung) 이영식(Young-Sik Lee) 조근호(Keun-Ho Joe) 나 철(Chul Na)
• 간행물 정보: 『중독정신의학』Vol.7, No.1, 20~27쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2003.04.30

영문 초록

Objectives：The present study was performed to evaluate the effectiveness of naltrexone combined CBT(cognitive behavior therapy). Method：This study design was double blind placebo controlled method. Naltrexone(n=13) and placebo(n=12) were added to CBT for 2 weeks in 25 subjects. Administered Naltrexone dosage was 23.4 mg/day in 1st week and 37.1 mg/day in 2nd week. Multimodal CBT technique was conducted for three times once every week. Total cigarette consumption amounts per a week, Brief Questionnaire for Smoking Urge (B-QSU), and expiratory CO levels, Fagerstrom Tolerance Questionnaire (FTQ) were checked at baseline and 4 weeks later. Results： 1) There were no differences between naltrexone add-on CBT group and CBT alone group in nicotine withdrawal symptoms and drug side effects containing GOT/GPT levels. 2) In Naltrexone add-on CBT group, total cigarette consumptions (p=0.021), the expiratory CO levels (p=0.039), B-QSU score (p=0.036), and FIQ scores (p=0.028) were significantly lower than CBT alone group. 3) Subjective reports about the smoking reduction are greater in naltrexone add-on CBT group than CBT alone (53.0% vs. 16.7%). Conclusions： Naltrexone and CBT combined therapy could be a effective and safe treatment in nicotine dependence.

키워드

Nicotine dependence Naltrexone CBT