흰쥐에서 임신, 수유, 성장기 동안 어유의 섭취가 대뇌피질의 지방산 조성과 학습능력에 미치는 영향

• 영문명: Effect of the Supplementation of DHA-Rich Fish Oil during Gestation, Lactation, and Growth on the Fatty Acid Composition of Cerebral Cortex and Maze-Learning Abilities in Rats
• 발행기관: 충북대학교 생활과학연구소
• 저자명: 이주희(Lee Ju hee) 김지원(Kim Ji won) 최혜미(Choi Hye mie) 이홍미(Lee Hong mie)
• 간행물 정보: 『생활과학연구논총』생활과학연구논총 제21권 제1호, 1~14쪽, 전체 14쪽
• 주제분류: 자연과학 > 생활/식품과학
• 파일형태: PDF
• 발행일자: 2017.06.30

영문 초록

This study was designed to investigate the effect of dietary docosahexaenoic acid (DHA) on the tissue fatty acid compositions and learning abilities of rat. Three experimental diets contained 10% (w/w) dietary lipids; corn oil based diet with perila oil (CO), corn oil based diet with fish oil (CF), and fish oil based diet (FO). Sprague Dawley female rats were fed experimental diets for approximately 2 weeks prior to mating and throughout gestation and lactation. Pups were weaned to the same diet of dams at 21 days after birth. Hepatic microsomal membrane fatty acid composition, thiobarbituric acid reactive substance (TBARS) contents and the activities of glucose 6-phosphatase (G6Pase) were measured at 7 weeks in female and 10 weeks in male rats. Cerebral cortex fatty composition and the activities of acetylcholinesterase were measured at 7 weeks. Learning abilities were tested at 8-10 weeks of age with Y water maze. The fatty acid composition of cerebral cortex were minimally, but significantly affected by that of dietary lipid than that of hepatic microsomal membrane; DHA contents were 19.2%, 20.4% and 21.9% in cerebral cortex and 8.92%, 14.2% and 19.4% in hepatic microsomal membrane of 7 week old female rats of CO, CF and FO groups. TBARS contents were the lowest in FO group at 10 weeks, and the activities of G6Pase were not affected by the experimental diets. The activity of acetylcholinesterase and learning abilities were not different among three groups. Therefore, dietary DHA supplementation to the diet with normal n-6/n-3 ratio and adequate amount of n-3 fat did not seem to promote brain functions determined in this study, nor lipid peroxidation and membrane completeness, despite significant small increase of DHA level in cerebral cortex.

목차

Abstract

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 결과

Ⅳ. 고찰

Ⅴ. 요약 및 결론

참고문헌

키워드

DHA Fatty Acid Composition Cerebral Cortex Maze-Learning Abilities Acetylcholinesterase