카드뮴에 폭로된 폐포된 폐포대식세포의 세포독성 평가를 위한 세포자계측정, LDH활성도 및 Apoptosis

• 영문명: In Vitro Magnetometry, LDH Activity and Apoptosisas Indices of Cytotoxicity in Alveolar Macrophages Exposed to Cadmium Chloride
• 발행기관: 한국환경보건학회
• 저자명: 조영채
• 간행물 정보: 『1. 한국환경보건학회지』제26권 제4호, 115~121쪽, 전체 7쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2000.12.30

영문 초록

To evaluate the cytotoxicity of cadmium compounds, this study was conducted to measure the in vitro magnetometry, LDH release and cellular apoptosis using alveolar macrophages of hamsters. A series of magnetometric measurements in cadmium-added groups showed a significant dose-dependent decay of the relaxation curves. The LDH release rates showed a dose-dependently increasing tendency as the dose gradually increased. The positive rates of apoptosis were significantly higher in cadmium-added groups than the control groups. Conclusively, the cytotoxicity increased in a dose dependent way as the concentration of cadmium added increased, which reflected in the decay of relaxation curve in magnetometry, and increased LDH release rate and positive rate of apoptosis.

키워드

Cytotoxicity Cadmium Magnetometry LDH release assay Apoptosis