자외선B파로 유도된 Hairless mouse의 과산화지질 및 항산화효소활성도와 탄닌의 효과

• 영문명: Lipid Peroxidation and Antioxidase Activities on Hairless Mouse Induced by UYB Irradiation and Effects of Tannic acid
• 발행기관: 한국환경보건학회
• 저자명: 이민경 이세윤 안형수 안령미
• 간행물 정보: 『1. 한국환경보건학회지』제22권 제4호, 102~108쪽, 전체 7쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 1996.12.30

영문 초록

Inhibitory effects of tannic acid on the lipid peroxidation induced by UVB were investigated. Tannic acid was administered either topically or orally for 3 days to hairless mice, which were previously irradiated with UVB, and inhibitory effects of tannic acid were measured. The UVB was found to cause skin erythema and hemolysis. When tannic acid was administered either topically or orally, hemolysis was decreased. After the skin was irradiated by UVB, the production of malondialdehyde was significantly decreased in erythrocyte and skin tissue, and the activities of SOD and catalase were significantly increased in plasma and skin tissue. In case of oral treatment, catalase activity was not significantly increased. The inhibitory effects of tannic acid on malondialdehyde production, SOD inhibition and catalase inhibition were more prominent in orally administerd groups than in topically administerri groups. However, the difference between two groups was not statistically significant. In conclusion, tannic acid decreased lipid peroxidation possibly by free radical scavenger action. The route of administrations, topical or oral, did not affect the antioxidative activity of tannic acid.

키워드

UNB hairless mouse tannic acid SOD TBA catalase hemolysis