크롬에 의한 CHO 세포의 세포독성기전에 관한 연구

• 영문명: Chromium-Induced Cytotoxicity in CHO Cells
• 발행기관: 한국환경보건학회
• 저자명: 기혜성 손은희 유일재 맹승희 정해원
• 간행물 정보: 『1. 한국환경보건학회지』제22권 제4호, 77~81쪽, 전체 5쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 1996.12.30

영문 초록

The present experiment was carried out to examine the mechanism of cytotoxicity of Chromium in CHO cells. Chromium induced chromosomal aberrations in a dose-dependent manner. The most frequent type of aberration was chromatid deletions and chromosome type exchanges were also observed. Ultrafiltrates of culture media from CHO cells treated with Chromium induced sister chromatid exchanges(SCE) in CHO cells and Chromium induced lipid peroxidation. It was suggested that indirect effect through formation of clastogenic factor(CF) as well as direct effect on DNA might contribute to the cytotoxicity of Chromium.

키워드

Chromium chromosomal aberrations clastogenic factor sister chromatid exchanges lipid peroxidation