Chitosan으로 표면처리된 인공매식치 계면에 대한 Confocal Laser Scannning Microscopy 연구

• 영문명: CONFOCAL LASER SCANNING MICROSCOPY STUDY ON INTERFACE BONE AND TITANIUM IMPLANT COATED BY CHITOSAN
• 발행기관: 대한구강악안면외과학회
• 저자명: 박연천(Yeun Chun Park) 안병근(Byoung Gun An) 박영주(Young Joo Park) 이용찬(Yong Chan Lee) 조병욱(Byoung Wouck Cho)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제24권 제4호, 440~447쪽, 전체 8쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1998.10.30

영문 초록

The purpose of present study was to observe the radiographic finding and histologic response by Confocal Laser Scanning Microscopy(CLSM) on interface of the bone and titanium implant coated by chitosan. The tissue response of rabbit tibiae to the surgical placement titanium implant coated by chitosan was examined at 3, 9 and 24 days postoperatively. The radiographic finding showed that surounding bone density of implants was not significantly different compare with the bone on 3 and 9 days group. A large amount new bone was formed on 24 days group, the reason was osteoconduction activity by chitosan. The CLSM analysis show that the surface coating by chitosan filled the gap between bone and implant on 3 days group and filled by new born on 9 days group. On 24 days group, the bone and titanium surface was filled by lamella bone. This results indicated that this enhanced the initial stability of implant significantly and chitosan induced osseointegration around implant. CLSM allows the non-destrutive histo-tomography of bone biopsy as well as clinical practice. We conclude that CLSM allowed a good comprehension of the nature of bone-implant contact, avoiding artifacts due to the thickness of the specimen

목차

Abstract

I. 서론

II. 재료 및 방법

III. 결과

IV. 고찰

V. 결론

참고문헌

키워드

confocal laser scanning microscopy chitosan initial stability