악교정 수술시 유도저혈압 마취를 위해 사용되는 Esmolol과 Nitroglycerin의 효과에 대한 비교 연구

• 영문명: A COMPARATIVE STUDY ON THE EFFECT OF ESMOLOL AND NITROGLYCERIN AS DRUGS FOR HYPOTENSIVE ANESTHESIA IN OREHOGNATHIC SURGERY
• 발행기관: 대한구강악안면외과학회
• 저자명: 정영수(Young Soo Jeong) 강정완(Jeong Wan Kang) 박형식(Hyung Sik Park) 이충국(Choong Kook Yi) 이의웅 (Eui Woong Lee)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제24권 제4호, 434~439쪽, 전체 6쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1998.10.30

영문 초록

Induced hypotension is used to help control bleeding during procedures where surgical hemostasis is technically difficult to achieve. A mean arterial blood pressure(MABP) as low as 50-60 mmHg appears to be well tolerable in healthy patients. The present study was designed to compare the efficacy of Esmolol and Nitroglycerin as primary drug for hypotensive anesthesia during 22 cases of orthognathic surgery, and compare their effects on blood loss, duration of surgery, quality of the surgical field, hormonal response, and patient outcome. The results obtained are as follows. 1. During the induced hypotension, mean arterial blood pressure was similarly reduced in esmolol group and nitroglycerin group. And any significant difference was not seen in the time of inducing hypotension from starting the drug administration, preoperative mean blood pressure and mean blood pressure during the period of postoperative recovery. 2. Difficulty of the operation, quality of the surgical field and total operation time in 2 groups show no difference but the time during hypotension was significantly reduced in esmolol group. 3. Urine output, administered fluid volume, transfusion volume of autologous blood, preoperative and postoperative base excess, preoperative and postoperative hematocrit had no difference between 2 groups. 4. The change of the plasma renin activity was more lowered in esmolol group than in nitroglycerin group. Based on the above results, esmolol can replace the nitroglycerin as a new primary drug for hypotensive anesthesia. Especially, esmolol is more recommendable than nitroglycerin on the effect of stability in renin-angiotensin system and prevent rebound hypertension in posthypotensive period.

목차

Abstract

I. 서론

II. 연구 대상 및 방법

III. 결과

IV. 토의

V. 결론

참고문헌

키워드

hypotensive anesthesia mean arterial blood pressure orthognathic surgery esmolol nitroglycerin