흰쥐의 발치와 재상피화에 따른 상피내 CGRP 면역양성 신경섬유의 분포변화

• 영문명: EVIDENCE OF INTRAEPITHELIAL CGRP IMMUNOREACTIVE NERVE FIBERS DURING REEPITHELIALIZATION OF EXTRACTION WOUND OF RAT
• 발행기관: 대한구강악안면외과학회
• 저자명: 변기정(Ki Jeong Byeon) 김진수(Chin Soo Kim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제26권 제4호, 369~372쪽, 전체 4쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2000.08.30

영문 초록

The purpose of this study was to investigate the distribution pattern of CGRP immunoreactive nerve fibers in the healing mucosa of extracion wound. Maxillary 1st molars of rats were extracted. All extraction sites and adjacent tissues of 3 groups of rats(1-week, 2-week and 4-week groups) were removed en bloc and processed for immunostaining and were subjected to light microscopic examination. The results obtained were as follows; In 1-week group, there was no difference in the distribution pattern of CGRP immunoreactive nerve fiber between epithelial margin adjacent to extraction socket and normal gingival epithelium. In 2-week group, some CGRP-immunoreactive nerve fibers were seen in epithelial layer. In 4-week group, many intercellular CGRP immunoreactive nerve fibers were abundant in all layers of immature epithelium characterized by scab on the mucosa and thick keratinized cell layer with irregular surface. Intraepithelial CGRP immunoreactive nerve fibers were reduced to normal level in adjacent mature epithelium. These results suggest that density of CGRP immunoreactive nerve fibers are increased transiently in epithelium during reepithelialization process and CGRP released from these nerve fibers may play an important role in the reepithelialization in the wound healing.

목차

Abstract

Ⅰ. 서론

Ⅱ. 재료 및 방법

Ⅲ. 결과

Ⅳ. 고찰

참고문헌

키워드

CGRP Reepithelialization Extraction socket