구강암에 대한 약용식물 추출물의 항암효과에 관한 연구

• 영문명: STUDIES ON ANTI-ORAL CANCER ACTIVITIES OF MEDICINAL PLANT EXTRACTS
• 발행기관: 대한구강악안면외과학회
• 저자명: 이영훈(Young Hoon Lee) 김여갑(Yeo Gab Kim) 김정희(Jung Hee Kim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제26권 제1호, 53~58쪽, 전체 6쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2000.02.28

영문 초록

Treatment of oral cancers with chemotherapeutic agents are evaluated as an effective method for remission to reduce cancer proliferation nowadays. But, minimization of side-effects such as bone marrow suppression, gastrointestinal toxicity and renal damage is another problem to be solved. Thus, a possible approach to develop a clinically applicable chemotherapeutic agents is to screen anticancer activity among traditional medicinal plants which have been used for thousands of years with very low side-effects in orient. In this study we focused on screening anti-oral cancer activities among 14 traditional medicinal plant extracts that revealed anticancer activities on other solid tumors. The results were as follow: 1. Methanol extract of Lepidium apetalum showed the highest anti-oral cancer activity against A253 cells. At concentration of 4㎍/ml, the cell viability was 48% under our experimental condition. IC50 value obtained was 4㎍/ml. 2. Methanol extract of Coptis japonica and Solanum nigrum were effective on KB cells. Cell viability observed were 62% and 67% at concentration of 4㎍/ml, and IC50 values were 12㎍/ml and 10㎍/ml respectively. 3. When the methanol extract of Lonicera caerule was combined with 2㎍/ml of cisplatin, the anticancer activity was synergistically increased. One hundred ㎍/ml of Lonicera caerule showed 92%(alone) or 59%(combined with cisplatin) cell viabilities. IC50 value of Lonicera caerule extract against KB cells was reduced from 301㎍/ml to 126㎍/ml when combined with 2㎍/ml of cisplatin. 4. Medicinal plant extracts effective on both A253 and KB cells were Coptis japonica, Lepidium apetalum, Solanum nigrum, Caesalpiniae Lignum, Curcuma aromatica.

목차

Abstract

Ⅰ. 서론

Ⅱ. 연구재료 및 방법

Ⅲ. 연구성적

Ⅳ. 총괄 및 고찰

Ⅴ. 결론

참고문헌

키워드

Anti-oral cancer activity Medicinal plant extracts IC50