악관절환자에서 Synovial fluid에 대한 단백질체 분석에 관한 연구

• 영문명: THE ANALYSIS OF SYNOVIAL FLUID BY PROTEOMICS FROM TMD
• 발행기관: 대한구강악안면외과학회
• 저자명: 변은선(Eun-Sun Byun) 김태우(Tae-Woo Kim) 김상균(Sang-Gyun Kim) 박태일(Tae-Il Park) 박준우(Jun-Woo Park) 윤필영(Pil-Young Yun) 김영균(Young-Kyun Kim) 채창훈(Chang-Hoon Chae)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면회과학회지 제34권 제2호, 113~118쪽, 전체 6쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2009.04.30

영문 초록

Temporomandibular joint disorder (TMD) can induce severe pain but, its pathogenic mechanisms remain poorly understood. In this study, we analyzed proteomes of human synovial fluid in the superior joint space in the patients with TMD, which is obtained during the treatment arthrocentesis. We’ve got this result that one of the spots was consistently down-regulated in synovial fluid of patients with TMD from analysis of protein pattern. Its molecular weight was estimated to be 33 kDa. Synoviolin was identified in our proteomics analysis of LC/MS/MS. This protein was recently reported as one of the proteins that might affect rheumatoid arthritis (RA). Synoviolin that might be associated with RA was detected in synovial fluid of patients with TMD. We can conclude that synoviolin might be involved not only in the pathogenesis of RA but also in TMD. In result, synoviolin might be involved in the pathogenesis of TMD and can be candidates as new therapeutic targets of TMD or early detection biomarkers.

키워드

Temporomandibular joint disorder (TMD) Proteomics Synoviolin