한국인 하악전돌증환자의 유전적 영향과 유전율에 대한 분석

• 영문명: Genetic influence and heritability in mandibular prognathism of Korean families
• 발행기관: 대한구강악안면외과학회
• 저자명: 김영호(Young Ho Kim) 조한영(Han Young Cho) 백채환(Chae Hwan Baek) 이아영(Ah-Young Lee) 김군종(Gunjong Kim) 김휘영(Whi Young Kim) 서영주(Young Ju Suh) 백승학(Seung-Hak Baek) 홍종락(Jongrak Hong) 팽준영(Jun-Young Paeng)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제36권 제6호, 502~507쪽, 전체 6쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2010.12.30

영문 초록

Introduction: This study examined the genetic influence of mandibular prognathism epidemiologically in Korean families. Materials and Methods: Over a 5-year period from 2005 to 2009, a questionnaire with a pedigree chart was given to 100 (male 51, female 49) probands with skeletal Class III mandibular prognathism, who had undergone orthognathic surgery in Samsung Medical Center. Results: The average age of the probands was 22.1. The average SNA, SNB and ANB angles of the probands were 81.2􀆆, 84.1􀆆and -2.9􀆆, respectively. A total of 2729 (male 1,354, female 1,375) family members were examined, and the affected ratio of the families was 3.5% with no significant difference between genders. 45% of families had at least one member with a Class III malocclusion other than the proband. The affected ratio of the first-degree relatives (10.9%) was significantly higher than those of the second-degree (3.3%) and third-degree (1.9%) relatives. The affected ratio of the total relatives from the male probands (4.2%) was significantly higher than that of the female probands (2.8%). Heritability (h2, Falconer’method) was estimated to be 29.8% (0.298±0.059) in first-degree relatives. Conclusion: These results showed the significant influence of mandibular prognathism with relatively low heritability in first-degree relatives in Korean families of probands, who had undergone orthognathic surgery to correct a skeletal Class III malocclusion.

키워드

Mandibular prognathism Genetic influence Epidemiologic investigation Heritability