RP titanium cap과 rhBMP-2를 이용하여 형성된 신생골의 미세전산화단층촬영을 이용한 평가

• 영문명: Evaluation of bone formation by recombinant human BMP-2 and rapid prototype titanium cap in rabbit calvaria using micro computed tomography
• 발행기관: 대한구강악안면외과학회
• 저자명: 한만승(Man-Seung Han) 정승곤(Seunggon Jung) 김방신(Bang-Sin Kim) 양지웅(Ji-Woong Yang) 국민석(Min-Suk Kook) 박홍주(Hong-Ju Park) 유선열(Sun-Youl Ryu) 오희균(Hee-Kyun Oh)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제36권 제6호, 466~472쪽, 전체 7쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2010.12.30

영문 초록

Introduction: This study examined the effect of recombinant human bone morphogenetic protein (rhBMP)-2 and β-tricalcium phosphate (β-TCP) on new bone formation in a rabbit calvarium using a rapid prototype titanium cap (RP Ti cap). Materials and Methods: Eight New Zealand white rabbits were used in this study. Hemispherical RP Ti caps (10 mm in diameter) were implanted subperiosteally on the rabbit calvaria. β-TCP was filled in the RP Ti cap in the control group, and rhBMP-2 soaked β-TCP was used in experimental group. The rabbits were sacrificed 2 and 4 weeks after the operation. The volume and pattern of newly formed bone was analyzed by micro computed tomography (CT). Results: Macroscopically, there were no abnormal findings in any of the animals. The micro CT images revealed new bone from the calvaria that expanded gradually toward the top of the titanium cap, particularly along the inner surface of the titanium cap in the experimental group at 4 weeks after grafting. There was no significant difference in new bone volume ratio between the control and experimental groups at 2 weeks after grafting. There was a statistically significant difference in the new bone volume ratio between the experimental (14.1±1.8 %) and control (7.2±1.5 %) groups at 4 weeks after grafting (P<0.01). Conclusion: The RP Ti cap can effectively guide new bone formation and rhBMP-2 can induce the new bone formation

키워드

Titanium cap Bone morphogenetic protein 2 Micro computed tomography