학술논문
Highly Enantioselective Phase-Transfer Catalytic α-Alkylation of α-tert-Butoxylcarbonyllactams: Construction of β-Quaternary Chiral Pyrrolidine and Pipperidine Systems
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- 영문명
- 발행기관
- 대한약학회
- 저자명
- LEE Myungmo PARK Yohan LEE Young Ju HONG Suckchang LEE Jae Kyun JEW Sang-sup PARK Hyeung-geun
- 간행물 정보
- 『추계총회 및 학술대회』(2011년), 247~247쪽, 전체 1쪽
- 주제분류
- 의약학 > 내과학
- 파일형태
- 발행일자
- 2011.11.09
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- Synthesis and Evaluation of Designed Heterocyclic Sphingoid Analogues
- Rh-Catalyzed Acylation and Cyclization of Primary Benzamides and Aldehydes: Direct Synthesis of 3-Hydroxyisoindolin-1-Ones
- Reversal Effect of Multidrug Resistance by a Novel (-)-Antofine Analog in Paclitaxel-resistant Human Lung Cancer Cells
- Chemical Fingerprints of Volatile Components in Acorus Species Rhizomes by Headspace Solid-Phase Microextraction-Gas Chromatography/Mass Spectrometry
- Macrolactin Antibiotics from a Marine-derived Bacterium Bacillus sp. 102CH635-3
- Determination of Clopidogrel in Human Plasma by LC-MS/MS and Clinical Pharmacokinetic Studies
- Antimicrobial Activity and DNA Fingerprint Analysis of Acinetobacter baumannii from Clinical Isolates in Korea, 2010
- Smart Adenovirus Nanoconjugates for Cancer Gene Therapy
- Effects of Chlorhexidine Digluconate on Rotational Rate of n-(9-Anthroyloxy)Stearic Acid in Model Membranes of Total Lipids Extracted from Porphyromonas gingivalis Outer Membranes
- Anti-fibrotic Effects of EW-7197, a Novel Transforming Growth Factor-β Type i Receptor Kinase (ALK5) Inhibitor, on Hepatic Fibrosis in SD rat BDL Model
- Drug Discovery Platform Technology - Druggability from PhysChem to ADME/Tox for New Drug Design
- Neuroprotective Effect of Ropinirole in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Toxicity in Mouse Model via Its Antiapoptotic Activity
- In vitro and In vivo Activities of New Oxazolidinones, LCB01-0229, LCB01-0648 and LCB01-0676
- Mechanism of Action Study of Hepatitis C Virus (HCV) NS5A Inhibitor, BMS-790052
- ‘Hanbang’ Cosmetics Based on The Korea's Traditional Herbal Medicine: The History and Current Trends in R&D
- Neuroprotective Effects of Chunghyuldan in Neurodegenerative Disease Models
- Development of a Simple, Rapid and Sensitive HPLCMS/MS Method for the Determination of Metoclopramide in Human Plasma
- Effects of Red Ginseng on Radical Scavenging Activity and Collagen Synthesis
- Eicosapentaenoic Acid attenuates Ultraviolet Radiation-Induced Down-Regulation of Aquaporin-3 in Human Skin Keratinocytes
- AMPK-dependent Hypoglycemic Effect of Ajoene, a Stable Garlic Component
- Role of Transient and Sustained ERK1/2 Phosphorylation on L-DOPA-induced Cytotoxicity in PC12 Cell
- Safety Evaluation of EW-7197, a Novel TβRÉ/ALK5 Inhibitor
- Oroxylin A Enhances Memory Consolidation by Increasing Hippocampal BDNF Levels
- The Effect and Mechanism of DA-9701 on 5-Hydroxytryptamine-induced Contraction of Feline Esophageal Smooth Muscle Cell
- Pharmacokinetic Characterization of a Novel Glucokinase Activator YH-GKA in Preclinical Species
- Rimonabant, a CB1 Inverse Agonist, Inhibits Hepatocyte Lipogenesis by Activating LKB1 and AMPK Axis
- Differential Regulation of Junctional and Non-Junctional Ca2+ Transients by Sarcoplasmic Reticulum Ca2+ Pump in Field-Stimulated Rat Atrial Myocytes
- Increased GLP-1 by Vildagliptin Has a Neuroprotective Properties via Anti-Inflammatory Effect
- Genetic or Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase Attenuates Methamphetamine-Induced Dopaminergic Toxicity
- Active Phyto-compounds Inhibit IL-4 Production by Inhibiting Phosphorylation of Signal Transducer and Activator of Transcription (STAT) 6
- (E)-2,4-Bis(p-hydroxyphenyl)-2-butenal, a IKKβ Inhibitor Suppresses NF-κB and STAT3 Signaling and Inhibits Colon Cancer Cell Growth
- Gene Expression Profiling of MCF10A Series of Ha-Ras Transformed Human Breast Epithelial Cells: Gene Expression Involved in EMT Pathway
- IL-6 Gene Offers Protective Potential Against Trimethyltin-Induced Neurotoxicity
- Convulsion-related Activities of Scutellaria Flavone Derivatives and Their Structural Relationship
- Effect of an 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor, SKI2852, in Type 2 Diabetes and Obese Mice
- Hyperglycemia Induces Complement Component 3 in Murine Brain Endothelial Cell and Microglial after Ischemic Injury
- Protective Effect of Scoparone against D-Galactosmine and Lipopolysaccharide-Induced Fulminat Hepatic Failure in Mice
- Pharmacological Evaluation of Donepezil Transdermal Patch
- Role of Calpain Activity in mTOR-autophagy Pathway in Kainic Acid-induced Epilepsy Rat Model Brain
- Inhibition of JNK1 to Treat Fat Accumulation and Oxidative Stress in the Liver
- Identification of NRF2 Target Genes in Human Cells
- Immunosuppressive Effects of Subglutinol Derivatives
- A Systemic Isolation Approach for Isolation of Compounds from Kalopanax pictus Leaves
- Alteration of Action Potential-Induced Peripheral and Central Ca2+ Releases by NCX Inhibition in Rat Atrial Myocytes
- Prenylated Flavonoids from the Roots of Sophora flavescens Promote Vascular Relaxation via Endothelium-Dependent Mechansims
- Parkinson’s Disease-associated LRRK2 Mutation Causes Abnormal Protein Accumulation-related Cytotoxicity
- Protective Effect of Silymarin on Experimentallyinduced Gastric Lesions: Involvement of Prostaglandins and TRPV1
- Anti-cancer Effect of Thiacremonone : Peroxiredoxin 6 May Be a Target of Thiacremonone
- SR 823 Induces Apoptosis in Activated Rat Hepatic Stellate Cells through Activation of Caspase 3
- Mechanism of 5-Hydroxytryptamine-induced Contractions in Feline Ileal Smooth Muscle
- Effect of Methyl 3,5-Dicaffeoyl Quinate on ROS Level, Mitochondrial Membrane Potential and the Release of Cytochrome C in HT-29 Cells
- Inhibition of Excitotoxic Insults by Red Ginseng Extract in the Primary Cultured Rat Cortical Cells
- Ameliorating Effects of Gypenosides from Gynostemma pentaphyllum on Acute and Chronic Stress in Mice
- Antioxidant Activity of Dichloromethane Fraction from Equisetum hyemale L.
- Pharmacokinetic Analysis of Phenylbutyric Acid and Its Metabolite, Phenylacetic Acid
- Anti-neuroinflammatory and Anti-amyloidogenic Effect of Magnolia Extract Prevents Lipopolysaccharide-Induced Memory Deficiency
- Effects of Ginsenosides on Sphingosine Kinase Activity and Sphingolipid Production
- Antioxidant, Anti-α-glucosidase, Anti-inflammatory, and Anticancer Activities of Leaf, Stem Extract and Root Extract from Berberis aristata DC
- The Analysis of Tanshinone IIA and Crytotanshinone in Salvia miltiorrhiza Extracts
- Betulinic Acid (BA) Suppresses Hepatic Gluconeogenesis through 5'-AMP-activated Protein Kinase in HepG2 Cells
- Determination of Tamsulosin in Human Plasma Determination of Tamsulosin in Human Plasma to a Pharmacokinetic Study
- Screening of Fermented Hwang-Ryun-Hae-Dok-Tang to Evaluate the Effect on Platelet Aggregation
- A Hyperglycemic Zebrafish Embryo Model
- The Characteristic Trends of Drug Abuse in Korea
- Inhibitory Effects of Alpha-synuclein on the Catecholamine Biosynthesis
- The Stability of Silver Nanoparticles in Glucose Solution for Toxicokinetic Study
- Growth Inhibition and G2/M Cell Cycle Arrest by (19Z)-Halichondramide from Chondrosia coricata in Human Lung Cancer Cells
- The Stability of Silver Nanoparticles in Exposure Media and their Effects on the Early Development of Zebrafish Embryos
- Induction of Cyclooxygenase-2 in Macrophages by Genipin: Role of NF-kB and AP-1 Signaling Pathways
- Antiproliferative Activity of Clitocybin C, a Novel Isoindolinone, is Mediated by Blocking ERK1/2 Phosphorylation in Rat Aortic Smooth Muscle Cells
- Low Level of Lead Can Induce Phosphatidylserine-Exposure and Erythrophagocytosis: A New Mechanism Underlying Lead-Associated Anemia
- Evidence of Anti-Obesity Effects of the Laminaria japonica Areshoung Ethanol Extract in High-Fat Diet Induced Obese Rat
- Down-Regulation of Th2-Associated Cytokine Expression and Selective Transcription Factors by Fisetin
- Enhanced Effect of IL-32γ on TNF-α-Induced Cell Death in Colon Cancer
- Effects of Dihydroartemisinin on PMA-induced Inflammatory Response in Raw 264.7 Cells
- Effect of Yacon on Platelet Function in Hypercholesterolemic Rabits
- Studies on Acute Hepatotoxicity Study of Pleuropterus multiflorus
- The Anti-Mutagenic Effect of Mistletoe Lectin (Viscum album L. var. coloratum agglutinin)
- Changes of Catecholamine Secretion in the Perfused Adrenal Medulla of the Alloxan-Induced Diabetic Rats
- Protective Effect of Sun Ginseng (SG), Heat-Modified Panax ginseng, on UVB-Irradiated Human Skin Keratinocyte and Human Dermal Fibroblast
- Induction of Mast Cell Degranulation by Triterpenoidal Saponins Obtained from Cimicifugae Rhizome via Membrane Destabilization
- In Vitro Evaluation for Carcinogenicity of Nine Frequently Used Herbal Medicines III
- The Rhizomes of Alisma orientale and Alisol Derivatives Inhibit the Allergic Response and Experimental Atopic Dermatitis
- Induction of Aldo-keto Reductases by Keap1 Inhibition in Human Cancer Cells
- Expression Profile of Transient Receptor Potential Channels in Rat Cardiac Myocytes
- RORα Increases Fatty Acid Oxidation in HepG2 Cells
- Antiplatelet and Antioxidant Activities of Three Green Pepper Varieties Cultivated in Korea
- Akt/mammalian Target of Rapamycin Counteract the Akt/mammalian Target of Rapamycin Counteract the Growth Factor I Receptor Monoclonal Antibody
- Up-Regulation of Homocysteine-Clearing Enzymes in Tamoxifen Resistant Breast Cancer Cells
- 5-Florouracil Decreases Expression Level of Nuclear Receptor NR1D1 in a p53-Dependent Manner
- Global View of Current Occupational and EnCancers with Omics Biomarkers
- CYP2C9*13 Allele Has an Impact on the Pharmacokinetics of Irbesartan
- Hypopigmenting Mechanism of Phenethyl Phenyl Ether Derivative through Inhibition of Expression and Activity of Tyrosinase
- Studies on Chemical Constituents of Piper retrofractum
- Early Neuronal Degeneration in The Dentate Gyrus is Critical for Cerebral Ischemia-Induced Neurogenesis
- Development of a Teaching-Service Model for the Nephrology Advanced Pharmacy Practice Experience (APPE)
- Mechanism of Glycyrrhizic Acid Inhibition of Kaposi's Sarcoma Associated Herpesvirus: Disruption of CTCF-Cohesin Mediated RNA Pol II Pausing and Sister Chromatid Cohesion
- Incorporation of Value of Drugs in Drug Price Negotiation and Price-volume Arrangement Policy
- The Evaluation of P-Glycoprotein Activity by Tumor Necrosis Factor-α and Interferon-γ Using Brain Efflux Index Method
- Enhancement of Protein Degradation System by JSO713 in vitro
- Increase of Antitumor Activity of Cytokine-Induced Killer Cells via Direct Interaction with Tumor Lysate-Pulsed Dendritic Cells
- Physiological Interactions between Nav1.7 and Nav1.8 Sodium Channels: A Computer Simulation Study
- CCR5 Deficient Mice Are Vulnerable to MPTPinduced Dopaminergic Neurotoxicity
- TRPV4 Regulates Neurotrophic Factor-Derived Axonal Growth: An Etiology for Congenital Sensory and Motor Neuropathies
- Regulatory Requirements for the Imported Finished Pharmaceuticals in China
- Practical Catalytic Asymmetric Synthesis of Drug Candidates
- The Possible Role of Intestinal Microflora in Pharmacological Activities of Natural Products
- Regulatory Requirements for the Imported Finished Pharmaceuticals in Korea
- Regulatory Requirements for the Imported Finished Pharmaceuticals in Japan
- Induction of Green Technology into Pharmaceutical Industry
- Guidance for New Extended-Release Solid Dosage Forms
- An Anti-allergic Peptide Drug Binding to Dimerized Truncated Translationally Controlled Tumor Protein
- Pharmaceutical Applications of Solid-state NMR and Membrane Mimetic Systems
- Current Trends of New Drug Development and R&D Programs Supported by MKE
- Development of Next Generation NSAID CG100649
- Cross-linked Polymeric Micelles for Delivery of Anticancer Drugs
- Survey of R&D and Industrialization of Vaccines in China
- Inhibitory Effect of C-Methyl Isoflavones Isolated from Abronia nana Suspension Culture on Aβ Production
- Role and Vision of the Medical Innovation Foundation
- Pharmacy Practices and Social & Administrative Pharmacy
- Discovery of HIF-1a Inhibitors for Anti-cancer Chemotherapy
- Directions of National Drug Insurance Policy Reflecting Value of Drugs
- Public Health and Social & Administrative Pharmacy : Focused on Safe Use of Drugs (2)
- Metabolomic and Lipidomic Study Using Direct-Infusion Nanoelectrospray Mass Spectrometry
- Clinical Pharmacy Faculty and Research on the Scholarship of Teaching
- Value of Drug and Drug Reimbursement
- Dynamic Imaging of the Interaction of Natural Killer Cells and Cancer Cells
- A Novel Chemopreventive Target of RSK2 in Human Skin Cancer
- Role and Vision of Clinical Drug Manufacturing Center within Daegu-Gyeongbuk Medical Cluster
- Chemoprevention of Skin Cancer with Dietary Anti-inflammatory Phytochemicals by Targeting the COX-2 Signaling Pathway
- GPCRs GPCRs and G Proteins: Emerging Molecular Targets for Cancer Chemoprevention
- Session Introduction
- Anti-inflammatory and Pro-inflammatory Mediators as Potential Targets for Chemoprevention and Therapy
- Molecular Targets of Cancer Preventive Phytochemicals
- Potential Biological Effects of Methanolic Extracts from Natural Herbs
- Future Directions of Pharmacy Education in the United States
- Discovering Cancer Prevention Translational Drugs: Basic Research to Clinical Practice
- Changes & Directions of Education for Other Health Care Professionals: Medical & Dental Education in Korea
- Integration of Biology and Chemistry: Design, Synthesis and Biological Evaluation of the Selective Regulators Associated with Cellular Signaling Pathways
- New Pharmacist License Examination in Korea: A Proposal for Global Harmonization
- Bacillus thuringiensis Isolated from Cow Milk as a Probiotic to Prevent Invasive Infections in Animals
- Orally Active Heparin Derivative for the Treatment of Rheumatoid Arthritis
- Niches for the Development of Memory T Cells in Response to Acute Viral Infection
- Combination Protocol of Surface Camouflage and Immunosuppressive Drugs for the Pancreatic Islet Transplantation
- IVIVC in Oral Drug Absorption: Integrating Drug Dissolution Profile with Permeability to Predict Product Performance
- Overview of Social Pharmacy Education Agenda in Selected Schools of Pharmacy in the U.S.
- Analysis of Metabolites of Major Components in Natural Medicines
- KSK5104, IKK-β Inhibitor for Treating Reumatoid Arthrotis
- Strategy for Biologics Development
- The Role of New Drug Development Center (NDDC) in Daegu-Gyeongbuk High-Tech Medical Innovation Foundation (DGMIF)
- Copy Number Variations in Normal Karyotype Acute Myeloid Leukemia and Their Association with Treatment Response
- Ceruloplasmin is an Endogenous Neuroprotectant in Response to Kainate Neurotoxicity in Rats
- Inhibition of Rat Prostate Testosterone 5α-Reductase Activity by Isoflavonoids
- The Role of Tumor Suppressor p53 in Transcriptional Regulation of Cancer Stem Cell Marker CD133
- Fermentation Enhances the in vitro Antioxidative Effect of Onion Extract via an Increase in Quercetin Content
- Effect of Red Korean Ginseng on the Pharrmacokinetics of Metformin in Rats with Renal Injury Induced by Gentamicin: the Restoration of Decreased Slower Renal Clearance by Red Korean Ginseng
- Nrf2-mediated Induction of Heme Oxygenase-1 Expression by Cyclopentenone Prostaglandin Analogues in Human Breast Epithelial Cells: Structure-activity Relationships
- Highly Enantioselective Phase-Transfer Catalytic α-Alkylation of α-tert-Butoxylcarbonyllactams: Construction of β-Quaternary Chiral Pyrrolidine and Pipperidine Systems
- IBOS-01, a Potent LXRa Activator that Enhances Expression of Lipogenic Genes and Keratinocyte Differentiation Markers in HaCaT Cells
- Inhibition of Osteoblastic Differentiation by Warfarin and 18-α-Glycyrrhetinic Acid
- Induction of Apoptosis by MHY-449 in Human Colon Cancer Cells
- Aesculetin Suppresses Proliferation of Human Colon Cancer Cells by Direct Targeting of Beta-catenin
- HS-1200, a Synthetic Chenodeoxycholic Acid Derivative, Induced Apoptosis Through p53- or p21-independent Pathways in HCT116 Human Colon Cancer Cells
- Paenibacillus sp. SMs 01 nov., Isolated from the Traditionally Fermented Saururus chinensis
- Generation of Cancerous Neural Stem Cells Forming Heterogeneous Glial Cancer by Asymmetric Self-Renewal
- Prolyl Isomerase Pin1 Enhances TPA-induced Phosphorylation of ERK1/2 via Its Interaction with MEK1/2
- 1-Dehydro-[10]-gingerone Inhibits LPS Binding to MD-2/TLR4 for Anti-inflammatory Activity
- Identification of Novel In Vitro Secreted Biomarkers for Cisplatin-induced Nephrotoxicity by Proteome Analysis
- The Role of Stearoyl-Coenzyme A Desaturase 1 in TG Synthesis and Lipotoxicity
- Effects of Flavonoids on MMP-13 Expression of IL- 1β-treated Articular Chondrocytes and Their Cellular Mechanisms: Inhibition of c-Fos/AP-1 and JAK/STAT Signaling Pathways
- Rapamycin Reduces TNF-α mRNA via Regulating 3’ AU Rich Element Region
- Polysaccharide Isolated from Mori Fructus Induces Phenotypic and Functional Maturation of Dendritic Cells
- Structural Study of Helicobacter pylori Folypolyglutamate Synthetase
- Modulation of UVB-induced Cellular Senescence by Over-expressed SIRT1
- Effects of Cysteine on the Pharmacokinetics of Tamoxifen in Rats with Protein-calorie Malnutrition: Enhanced Gastrointestinal Absorption by Cysteine
- Apicidine, a Potent HDAC Inhibitor, Increases the Yield of Mature Dopaminergic Neurons via Up-regulation of Foxa2 Expression
- 15-deoxy-12,14-prostaglandin J2 Induces Phosphorylation of Akt via Covalent Modification of the Tumor Suppressor PTEN in MCF-7 Cells
- Identification of Arrestin-3-specific Residues Important for JNK3 Activation
- Maturation of Bone Marrow-derived Dendritic Cells by β-glucan Curdlan
- Guggulsterones Induces Heme Oxygenase-1 Expression via Nrf2 Activation in Human Mammary Epithelial Cells: a Potential Role of PTEN
- AglRhz from the Rhizochalina Incrustata Induces Apoptosis in HT-29 Colon Cancer Cells via Activation of AMPK
- The Src-Family Kinase Fyn is Critical for the Activation of DAP2/FcRγ-Mediated Costimulatory Signals by RANKL During Osteoclastogenesis
- Regulation of Human SMAD4 Gene Expression in the Gastric Cancer Cells
- Taurine Enhances Cisplatin-induced Anticancer Effects in Human Cervical Cancer Cells
- The Effect of siRNAs to EBV BHRF1 on the Chemoresistance of EBV-Associated Gastric Carcinoma
- Effects of Antioxidizing Activity, Anti-Platelet Aggregation Capacity and Stability of Anthocyanins from Blueberry, Cranberry and Red Cabbage
- Heterochromatin Protein (HP1) Loads the FACT Histone Chaperon Complex onto Elongating by RNA Polymerase II
- Total Synthesis of 4-O-Methylhonokiol
- RIG-I-Mediated Antiviral Immunity through Crosstalk between IPS-1 and PI3K/Akt
- Hypopigmenting Activity of Bisabolangelone by Blocking cAMP-Dependent PKA Activation
- Age-Related Changes in Experimental Autoimmune Encephalomyelitis: Severity of Experimental Autoimmune Encephalomyelitis is Increased in Old Mice
- IFN-γ Stimulated Human Nasal Polyp Fibroblasts Express the Galectin-9 through MAPK, PI3K, and JAK/STAT Signaling Pathways
- Recruitment of Cytokine-Induced Killer Cells into Tumor Environment through CCR5 and RANTES Signaling
- Mammalian Ste20-like Kinase and SAV1 Promote 3T3-L1 Adipocyte Differentiation by Activation of PPARγ
- Proyl Isomerase Pin1 Induces Tamoxifen Resistance in Breast Cancer Cells Through Downregualtion of CDK10
- EGFR and K-Ras Mutations and Resistance of Lung Cancer to the IGF-1R Tyrosine Kinase Inhibitors
- Ouabain Induced Cell Death of Tumor Cell is Determined by Intracellular Translationally Controlled Tumor Protein (TCTP) Level
- Prolyl Isomerase Pin1 Facilitates Tamoxifen Resistance via Induction of LC3 Expression
- Pro-resolving Effects of 15-deoxy-Δ12,14-prostaglandin J2 through Nrf2-Mediated CD36 Expression in Murine Macrophages
- Ubiquilin1 Downregulates the Orai1 Mediated Calcium Mobilization
- Chemopreventive Effects of Oligonol on Dextran Sulfate Sodium-induced Mouse Colitis and Underlying Biochemical Mechanisms
- Anti-inflammatory Effect of Yuanhuadine by Inhibition of MyD88-dependent Signaling Pathway in LPSinduced Macrophages
- Estrogen Receptor alpha Activated by both the MAPK and PI3K Pathway in Hypoxia
- Liver X Receptor alpha Enhances Transcriptional Activity of HIF-1a that Results in Lipid Accumulation in HepG2
- IL-32γ Potentiates Cytotoxicity of Natural Killer Cell to Cancer Cell K562
- Streptococcus pneumoniae D39 Induces Apoptotic Cell Death in Neuroblastoma Cells
- CCL17 miRNA Induced Immune Suppression on Atopy Dermatitis Model
- ATF3 is a Positive Regulator of IFN-γ-induced Production of IL-18
- Synthesis, Cytotoxicity, and DNA Topoisomerase Inhibitory Activity of Triazoloquinolinediones and Triazoloquinoxalinediones
- Stimultaneous Analysis of Bioactive Metabolites from Ziziphus jujuba by HPLC-DAD-ELSD-MS/MS
- Modification of Selective Cytochrome P450 1B1 Inhibitors
- Design of N-Aromatic Acyl-Amino Acid Conjugates as a Colon-Specific Prodrug with Controlled Conversion Rate at the Target Site
- Practical Method for Determining the Double Bond Positions in Long-Chain Olefins
- New Strategies of Antigen Transduction to Enhance the Efficacy of Anti-tumor Vaccine Based on B cells
- Establishment of an Assay for the Identification of Inhibitors of Swimming and Swarming Motilities
- In silico Identification of Potential Histone Methyltransferase G9a Inhibitors
- Synthesis of Isoflavone and Flavone Analogs as Estrogen Receptor Agonists
- Synthetic Approach to the Chemical Isostere of OMethyl Honokiol
- Seven New Cyclostellettamines from the Korean Sponge Haliclona sp.
- Structure-Based Virtual Screening Against the HIV-1 Frameshift Inducing RNA Stem-loop
- Fragment Screening Against Therapeutic Target by NMR Spectroscopy
- Polydiguanide Silver Complexes: Synthesis and Bactericidal Activity Against Burn Wound Pathogens
- Structural Requirement of Chalcone and Chromone Hybrid Analogs for the Inhibitory Activity of Interleukin-5
- Title Antifungal Activities of Substituted furo[2,3-f]quinazolin-5-Ols
- Chondroitin-Sulfate and Acharan Sulfate-Reduced Silver Nanocomposites with Promoted Antibacterial and Wound Healing Activities
- Methylscutelloside, a New Iridoid from Buddleja Officinalis
- A Short, Efficient, and Stereoselective Total Synthesis of α-Conhydrine
- Design, Synthesis and SAR of Substituted Benzamide Derivatives as Glucokinase Activators
- Molecular Design and Synthesis of Aminopyrazole Amide Scaffold as Type II Raf Kinase Inhibitors
- Anti-Allergic Evaluation of Synthetic Hinokiresinol Derivatives
- Synthesis of Streptopyrrolidine and its Derivatives as Angiogenesis Inhibitors
- An Enantioselective Synthesis of (+)-Polyoxamic Acid Via Phase-transfer Catalytic Conjugate Addition and Asymmetric Dihydroxylation
- Caffeic Acid Phenethyl Ester Activation of Nrf2 Pathway Is Mediated by Covalent Binding to Keap-1
- Risedronate Increases Osteoblastic Differentiation and Function through Connexin43
- Inhibitory Effect of Methanol Extract of Ardisia tinctoria Pit on Inflammation is Mediated by Suppression of NF-κB and ERK Activation Signaling Cascade
- Cystamine(CTM) Inhibits Pigmentation Processes in α-MSH Stimulated SK-MEL-2 Human Melanoma Cells
- Omega-3 Fatty Acids Suppress Cytokine Gene Expression Related to Allergy and Selective Transcription Factors in Mast Cells
- Screening for Small Molecule Probe of in vitro-in vivo Lipid Research and its Use for in vivo Lipid Imaging
- New Psammaplysin Analogs from the Tropical Marine Sponge
- Expression Profiles of Novel miRNAs during Differentiation of Human ES Cell, hms-smR-9 and 28 Potentially Regulate Their Target Genes in Endothelial Cells
- Tob1 Inhibits Proliferation, Migration and Invasion of Gastric Cancer Cells through Activation of Smad4 and Inhibition of b-catenin Signaling
- Novel Immune Stimulating Natural Herb for the Treatment of Infectious Disease
- Effusanin Inhibits Inflammation via Inhibiting NFkB and MAPK Signaling in Monocytes
- Myd88-Mediated Signaling Regulates Immunosuppressive Function of Myeloid-Derived Suppressor Cells
- Identification of Substrain of Commercial BCG Vaccines by Modified Multiplex PCR
- Genotypic Investigation of Multidrug-resistant Pseudomonas aeruginosa from Clinical Isolates in Korea, 2010
- Modulation of T Helper Cell Lineage Commitment by T-bet Modification
- Secreted Frizzled-Related Protein-1 Regulates Human Th17 Cell Differentiation by Enhancing TGF-β Signaling
- Asymmetric Total Synthesis of D-xylo- and D-arabino-Phytosphingosine
- Poly(ADP-ribose)polymerase-1 Binds to the Gquadruplex in the c-Myc Promoter and Regulates Gene Expression
- Cationic Liposomal Co-delivery of Small Interfering RNA and a MEK Inhibitor for Enhanced Anticancer Efficacy
- Monitoring of Bioactive Marker Compounds from Lycii Fructus by HPLC
- Inhibition of SNURDs from SNUPH on HIV-1 Protease
- Neuroprotective Effects of Phlorotannins from Edible Brown Alga Eisenia bicyclis on Beta Amyloid-Induced Toxicity in PC12 Cells
- Quantitative Analysis of KR-66*** in Plasma by LC-MS/MS and Application to a Pharmacokinetic Study
- Brain Tissue Binding (BTB) Assay Set-up and Application for Prediction of Free Drug Concentration in Rat Brain
- Determination of Seven Components by HPLC-PDA, and Evaluation of the Cytotoxicity of Palmul-tang
- Flavonol Glycosides and Phenolic Compounds from Euphorbia maculata
- The Ameliorating Effects of Kami-OnDam-tang (KODT) on the MK-801-Induced Schizophrenic Phenotypes in Mice
- Effect of Poncirin from Poncirus trifoliata on RANKLinduced Osteoclast Differentiation
- Anti-obesity Effect of Vitis Amurensis Root on 3T3-L1 Preadipocytes
- Baby Aloe Extract Protects Against UVB-induced Photoaging in Human Skin Fibroblast
- Cytotoxicity and DNA Topoisomerase Inhibitory Activity of Constituents from Inula japonica Thunb.
- Simultaneous Identification of Active Components in Oxidative Hair Dye Products by UPLC
- Synthesis and Anti-oxidant/Anti-excitotoxic Activity of (1S)-(-) Verbenone Derivatives
- Synthesis and Antifungal Activity of Benzo[f]pyrido [1,2-a]indole-6,11-Diones
- 4-Chlorotetrazolo[1,5-a]quinoxaline Inhibits Activation of Syk Kinase to Suppress Mast Cells In Vitro and Mast Cell-Mediated Passive Cutaneous Anaphylaxis in Mice
- Design and Synthesis of Benzylidenethiazolidinedione Derivatives as PTP1B Inhibitors
- Imidazolidinone as Essential Motif in 4-Phenyl-NArylsulfonylimidazolidinone for their Anticancer Activity
- In Vitro Na+/K+-ATPase Inhibitory Activity of Acylated Kaempferol Glycosides Isolated from Laurus nobilis L.
- Synthesis and Biological Evaluation of α,β-Unsaturated Lactones as Potent Immunosuppressive Agents
- Chemical Constituents of Soft Coral Lobophytum compactum in the Sea Vietnam and Cytotoxic and Antioxidant Activities of Some Diterpenes and Sterols
- Chemical Constituents Isolated from the Steamed Artemisia iwayomogi
- Synthesis 2,3-Dihydronaphtho[1,2-b]furan-2-Carboxamide Derivatives as Potential Inhibitory Agents of NF-κB
- Application of Oxazine Formation by Pd(0) Catalyst to Synthesis of Radicamine B
- Nitric Oxide Inhibits HIF Prolyl Hydroxylase by Competing with Oxygen: Implication in Discriminative Action on Prolyl-4-Hydroxylases
- Synthesis and Anticancer Activity of Novel SAHA Derivatives with a Bulky Aromatic Cap
- Synthesis of Bio-Conjugate Using Succinimidyl Ester of Coumarin Dendrimer as the Potential Fluorescent Compounds for the Detection of Specific Antigen
- Development of Nucleic Acid-Polyethyleneimine Polyplex Nano-Particle by Supercritical Fluid Technology for Dry Powder Inhaler
- Highly Efficient Synthesis of Aryl Ketones: Rh-Catalyzed Acylation of Benzamides with Aldehydes
- Identification of Indoline-2-Thione Analogs as Novel Potent Inhibitors of α-Melanocyte Stimulating Hormone Induced Melanogenesis
- Phytosterol-Based Novel HUVEC-Apoptosis Inhibitors: Insight into Their Structure-Activity Relationships
- Methyl Gallate Inhibits Lipid Accumulation
- Phenalenone Metabolites from the Marine Fungus Penicillium sp
- Rapid Determination of Propofol and Its Metabolites in Human Urine by LC-ESI-MS/MS
- Determination of Erlotinib in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry with Electrospray Ionization
- Evaluation of Dissolution Tests for Domperidone Tablets
- Biodistribution and PK Study of Human Papillomavirus 16L1 DNA via Human Endogenous Retrovirus Envelope Protein-expressing Baculovirus
- Developing an Optimal Tablet Formulation to Overcome a Poor Flowability and High Hygroscopicity of Herbal Extract
- Formulation and Evaluation of Nifedipine 'opencap' Tablet Using Eudragit？？ coat to Achieve Zero-order Release Profiles.
- Enhanced Transfection Rates of Nucleic Acids Using Dioleylglutamide-based Magnetic Lipoplexes
- Development of Prediction Marker for SSRIs Responses, Depends on Platelet Physiological Function
- Analysis of Factors Related to Gastrointestinal Drug Use in Korean Adolescents
- Analysis of Cardiovascular Adverse Drug Reactions Reported the Korea Drug and Food Administration
- Update on the Regulation and Development of Cell/Tissue-Based Products in Japan
- Single Dose Toxicity Study of Quercus salicina Blume in Rats
- iFRET Technology as a Novel Tool for Drug Discovery
- Toxicological Studies on Honeybee Venom for External Application
- Establishment of Assay Specifications in Forsythia Fruit
- Sialyllactose-reduced Silver Nanocomposites with Antibacterial Activities
- Child Molecule Generation of Pyrazolylpyrrole Scaffold as ERK Inhibitors Utilizing Dual Tools; 3D-QSAR and Side-Chain Hopping
- Asymmetric Synthesis of Piperidine Alkaloide, DFagomine
- Antihyperglycemic Effect of Fermented Gastrodia elata Blume on Streptozotocin-Induced Diabetic Mice
- Determination of Volatile Oil Components in Angelicae sinensis Diels by GC-MS
- Zizyphus jujube Ameliorate DSS-induced Colitis in Mice
- The Protective Effect of Schizandra chinensis on DSS-induced Colitis
- Development of LC-MS/MS Method to Monitor Collagen Pentapeptide Stability in Rat Skin
- Chemistry, Maunfacturing and Control in Global Botanical Drug Development
- Development of a Novel Botanical Drug for the Treatment of Functional Dyspepsia
- Concise and Stereocontrolled Syntheses of DAB-1 and D-Fagomine
- Analysis of Saponins by Direct Analysis in Real Time Mass Spectrometry Combined with In-situ Derivatization
- Antitumor Activity and Immunomodulating Effect of Herbal Extract WK5 in Combination with 5-FU against CT 26 Colorectal cancer cells implanted Mice.
- Mutations of Helicobacter pylori Associated with Clarithrmycin or Fluoroquinolone Resistance in Korea
- Silver-Mediated exo-Selective Tandem Desilylative Bromination/Oxycyclization of Silylacetylenic Alcohols
- Antimicrobial Metabolites of a Marine Sponge-Derived Penicillium sp.
- Phytochemical Study on Abutilon theophrasti
- Classification of Cannabis sativa L. by the Contents of Cannabinoids and the Characteristics of Stable Isotope
- Screening of Radical Scavenging Activity of Jupgolmok
- Inhibitions of Urinary Oxidative Stress by an Extract of Quercus salicina Blume in a Rat Calcium Oxalate Urolithiasis Model
- The Role of Scoparone from Artemisia capillaris on Erectile Dysfunction
- A New Oleanane-Type Triterpenoid from Aster yomena
- A New Spirobenzylisoquinoline Alkaloid from P.setigerum D.C.
- Validation of High-Performance Liquid Chromatography Analysis on Phenolic Substances of Cirsium setidens and Sedative Effect of Pectolinarin as the Active Principle
- Anti-Inflammatory Activity of Galloyl Flavonol Glycosides from The Leaves of Myrica Rubra
- Simultaneous Quantification of 11 Chemical Components in Traditional Herbal Medicinal Formula Socheongryongtang by HPLC-DAD and LC-MS
- A New Lignan from Saururus chinensis
- Establishment of Dissolution Specifications for Clonixin Lysinate Tablets
- Development of Tacrolimus-loaded Liquid Crystalline Nanoparticles for Intradermal Delivery
- Down-regulation of P-glycoprotein Expression by Honokiol, Magnolol, and 4-O-methyl-honokiol, the Constituents of Magnolia grandiflora L
- Development of a Capillary Electrophoretic Method for the Determination of the R-enantiomer of Valsartan
- Developing an Improved Pre-column Derivatization Method for the Analysis of Monosaccharides from Biofilms
- Validation of Analytical Method and Pattern Analysis of Achyrantis Radix
- Validation of a Method for Assaying for Propofol (2,6-diisopropylphenol) and Concentrations in Whole Blood Specimens from Autopsied Cases
- Authentication of Rhubarb Species by Simultaneous Quantitation of Bioactive Components and Pattern Recognition Analysis
- Microfluidic Device-Based High-Content Screening of Drug-Induced Cardiotoxicity Using Quantitative Single Cell Imaging Cytometry
- Pharmacokinetics of Capsaicin and Resveratrol and Their Effects on the Tissue Distribution of Paclitaxel, a Substrate for P-glycoprotein
- Development of Dissolution Testing Method for Sobrerol Capsules in Korean Pharmaceutical Codex
- K-BEtest SP; an Integrated Computer Program for the Analysis of Bioequivalence
- Enhanced Adenoviral Gene Transfer by Complexing with Novel Liposomal Formulations
- Impact of the Breast Cancer Resistant Protein and P-glycoprotein in the Intestinal Transport of Gemifloxacin
- Development of Sibutramine Base / β-cyclodextrin Complex Formulation
- Enhanced Antibacterial Activities of Leonuri Herba Extracts Containing Silver Nanoparticles
- Photo-stability and Sustained Release Improvement of the Isradipine Using Inclusion Complex
- Characterization and Preparation of Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carrier (NLCs) as Vehicles for Oral Delivery of 6-Methoxyflavone
- A Novel Technique for Liposomal Encapsulation of Oligonucleotide Therapeutics
- Properties of Amniotic Membrane Extract for Potential Use in Anti-Scar Therapy
- Effects of Vehicles and Enhancers on the In Vitro Permeability of Meloxicam (MX) through Hairless Mouse Skin
- Blood Concentrations of Sulindac and its Metabolites in Pregnant Women with Preterm Labor
- Association between Tissue Plasminogen Activator (PLAT) and/or Plasminogen Activator Inhibitor Type 1 (SERPINE1) Polymorphisms and Warfarin Maintenance Doses
- Doxorubicin-Induced Platelet Procoagulant Activities: An Important Clue for Chemotherapy-Associated Thrombosis
- Valrpoic Acid Induces Neurite Outgrowth via Modulation of tPA/PAI-1 Activity in Rat Primary Astrocytes
- Conditioned Place Preference of Tiletamine and Zolazepam
- Ninj1 as a Novel Therapeutic Target for Inflammatory Diseases
- Involvement of TRPM2 in a Defense Mechanism of Amyloid Precursor Protein against ROS-induced Cell Death
- Expansion of Follicular Helper T cells During Chronic Salmonella Exposure Mediates the Generation of Autoimmune Hypergammaglobulinemia in MyD88-Deficient Mice
- Key Technology for Monoclonal Antibodies Bioprocess and Manufacturing
- Changes of Pharmacy Education in Japan
- The Optimal Culture Condition for Mycelial Growth of Aspergillus parasiticus Speare
- Synthesis and Antiviral Activity of D- and LBicyclo[3.1.0]hexenyl Carbanucleoside Derivatives
- SR823 Inhibits Nitric Oxide Production in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages
- Identification of the Molecular Targets of Isoliquiritigenin in Human Lymphoblastoid Cell Lines
- Green Tomato Extract Attenuates High-fat Dietinduced Obesity in C57/BL6 mice
- Four New Oleanane Triterpenoids Possessing Unusual Bis-Hydroxymethyl Group from Rhododendron brachycarpum
- Pharmacokinetics of Esculetin in Control and Pseudo Germ-Free Rats
- Comparison of In Vivo Efficacy of an Intratumoral Injection between Doxorubicin Only and In Situ-Forming Gel
- Systems Chemo-informatics Approach to Lead Discovery and Optimization
- Global Botanical Drug Development Utilizing the Plant Stem Cell
- Future Directions of Pharmacy Education in Korea
- Compounds Isolated Alnus hirsuta from Improves Glucose Uptake via Insulin Receptor
- Dual Effects of AT1 Receptor Blocker on Catecholamine Release from the Rat Adrenal Medulla
- Sulforaphane Suppresses LPS-induced COXII Expression via ATF3/NFκB p65 Complex
- A Bark of Betula platyphylla Regulates Mast Cellmediated Allergic Inflammation In vivo and In vitro
- Effects of Vehicles and Enhancers on the In Vitro Permeation of Lornoxicam Across Excised Skin
- Geniposidic Acid Protects D-Galactosamine and Lipopolysaccharide-Induced Apoptotic Liver Injury
- Phage-Mediated Inhibition of Bacterial Group Behaviors in Pseudomonas aeruginosa
- PEGylated Peptide and Protein Drugs
- Resveratrol Inhibits IL-6-induced STAT3 Activation in Human Colon Epithelial Cells; SIRT1 as a Potential Target
- Synthesis of 125I-Labeled T1AM and Its Micro-SPECT/CT Imaging Study
- Anti-Atherogenic Effects of Hexane Extracts of Yam, Dioscorea batatas Decne
- Evaluation of In-hospital Cardiac Arrest at a Teaching Hospital in Korea
- Target Validation and in Silico ADME Study of Monocyclic Nitroimidazoles for Mycobaterium Tuberculosis
- 2-Alkylthio Substituted Naphthoquinones as Acyl-CoA: Cholesterol Acyltransferase (ACAT) Inhibitors
- Traditional Medicine in the Treatment of Dementia and Alzheimer’s Disease
- Anti-inflammatory Activity and Protective Ability of Water Extract from Pinus densiflora Bark against DNA Damage
- Optimization of Formulation Parameters via Physicochemical Characterization of Rosiglitazone-loaded Cationic Lipid Emulsion
- Isolation and Structure of Irciniastatin C from the Tropical Marine Sponge Ircinia ramosa
- Blood Mediators Can Induce Anemia in Chronic Kidney Disease through Phosphatidylserine Exposure-Mediated Erythrophagocytosis
- Molecular Docking Studies of (1E,3E,5E)-1,6-bis (substituted phenyl)hexa-1,3,5-triene and 1,4-bis(substituted trans-styryl)benzene Analogs as Novel Tyrosinase Inhibitors
- In vitro Evaluation of Secreted Biomarkers for Cisplatin-induced Nephrotoxicity Using HK-2 Human Kidney Epithelial Cells
- Stereoselective Synthesis of α-(-)-Conhydrine
- Global Botanical Drug Development for Respiratory Disease
- Principles and Applications of NMR-based Metabolomics
- Helicobacter pylori infection and the Development of Gastric Cancer
- Epigenetic Changes Induced by Reactive Oxygen Species in Hepatocellular Carcinoma: Methylation of the E-cadherin Promoter
- Effects of Chenopodium album Linne on Gastritis and Gastric Cancer Cell Growth
- Bioactivity of So Cheong Ryong Tang with Steaming Process
- Metabolomics and Its Application
- Development of Shinbaro, a New Herbal Medicine in the Treatment of Osteoarthritis
- GRASP-Dependent Unconventional Trafficking of CFTR
- Present Status and Future Aspects of Whitening Cosmetics
- The Anti-allergic Effect of Ribes fasciculatum var. chinense MAX In vivo Model
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