학술논문
Population Pharmacokinetics of a Novel Histone Deacetylase Inhibitor, SD-2007, and Its Metabolic Conversion to Apicidin after Intravenous Injection and Oral Administration in Rats
이용수 2
- 영문명
- 발행기관
- 대한약학회
- 저자명
- KIM Min-Gi KIM Tae-Hwan SHIN Beom-Soo BULITTA Jü rgen B.2 HONG Deok-Ki KIM Hye-Youn LEE Jong-Bong WANG Sang-Wook CHOI Yo-Han SEO Won-Sik YOO Sung-Dong
- 간행물 정보
- 『춘계총회 및 학술대회』(2011년), 294~294쪽, 전체 1쪽
- 주제분류
- 의약학 > 내과학
- 파일형태
- 발행일자
- 2011.04.22
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- Neuroprotective Effects of Apigenin Against Kainic Acid-induced Seizures
- Growth Inhibition of Colon Cancer Through Inactivation of STAT3 Pathway in Co-culture with Murine Macrophage
- PI3K/AKT Inhibitors Isolated for Natural Products by HIV-1-transfected CHME5, a Human Microglia Cell
- Role of Prodynorphin Gene in the Dopaminergic Toxicity Induced by MPTP or Methamphetamine
- Role of Cyclic AMP on L-DOPA-induced Cytotoxicity in PC12 Cells
- QUYEN Buy T, KANG Keon Wook Neural Progenitor Cell and Brain Development
- Effects of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose on the Metabolism of Amyloid Precursor Protein
- Anxiolytic Effects of the JA-Q: Involvement of GABAergic System
- Effects of Morin on the Pharmacokinetics of Docetaxel in Rats with7,12-Dimethylbenz[a]anthracene (DMBA)-induced Mammary Tumors
- Anti-dementic Effect of Sinapic Acid on β-amyloid Protein-induced Mouse Model
- Inhibition of Tumor Necrosis Factor-α-induced Expression of Cell Adhesion Molecules by Ginsenoside Rg3
- Role of the Keap1-Nrf2 Antioxidant System in TGFb-mediated Epithelial-to-mesenchymal Transition in Renal Epithelial Cells
- A New Drug Target Identification System, PomSPomS™: An Emerging Technology for Drug Target Discovery Using Bioneer’s S. pombe Genome-wide Heterozygous Deletion Mutant Library
- Crucial Role of PI3K in MAT2A Expression via Regulating Nrf2 and NF-kB in Tamoxifen-Resistant Breast Cancer Cells
- Nrf2-mediated Liver Protection by an Antioxidant Lignan from Acetaminophen Toxicity, as Mediated by PKCδ-GSK3β Pathway
- The Anti-allergic and Anti-inflammatory Effect of Essential Oils from Pinus koraiensis S. et Z.
- Negligible Effects of Nitroglycerin on Pharmacokinetics and Pharmacodynamics of Mirodenafil in Rats
- Methylphenidate Treatment in the Spontaneously Hypertensive Rat: Influence on Methylphenidate Selfadministration and Reinstatement in Comparison with Wistar Rats
- Snake Venom Toxin from Vipera lebetina turanica Sensitizes Human Colorectal Cancer Cells to TRAIL through Up-regulation of Death Receptors
- The Protective Effect of HBED, an Iron Chelator, against H2O2-induced Cell Death via sAPPα Release Enhancement in HT-22 Cells
- Role of Intracellular Hydrogen Peroxide in the Acid-induced Responses of Cultured Feline Esophageal Epithelial Cells
- Antidiabetic Effect of Codonopsis Lanceolata through the Regulation of Glucose Metabolism in C75BL/ KsJ-db/db Mice
- Anti-allergic Effects of the Compounds from Thujopsis dolabrata by Decreasing IL-4 mRNA and beta-Hexosaminidase from Allergen Induced RBL-2H3 Cells
- Meloxicam Pharmacokinetics and Pharmacodynamics in Relation to CYP2C9 Genotype
- Inhibition of Cell Growth via NF-κB-mediated G2/M Phase Cell Cycle Arrest by 2,4-Bis(p-hydroxyphenyl)-2-butenal in Human Colon Cancer Cells
- Antioxidant Activity of Water Extract from Green Tea
- Age-Related Differential Effects of Organophosphate Pesticides on the Murine Splenocytes
- Mutation of Presenilin 2 Inhibits Lung Tumorigenesis and through Inhibition of Peroxiredoxin-6 Expression
- Inhibitory Effect of HK 10 on Proliferation of Vascular Smooth Muscle Cells through Suppression of PDGF-Receptor Beta
- Pulsatilla koreana Extract Reduces Thyroid Cancer Progression by Inducing Apoptosis and Inhibiting Angiogenesis In vitro and In vivo
- Estrogen Receptor-Mediated Effects of Party Pill Drugs in Human Breast Cancer Cells
- Inhibitory Effects of Flavonoids on Aromatase Activity
- Protective Effects of Activated Cultivated-Wild Ginseng Against Hepatotoxicity Induced by Carbon Tetrachloride in Rats
- Berberine Induces Hepatic Steatosis via C/EBPβ Activation
- Anti-wrinkle Effect of Korean Rice Wine Cake
- Protective Mechanisms of Anthocyanin-Rich Purple Sweet Potato Extract against tert-Butyl Hydroperoxide-Induced Hepatotoxicity
- Determination of Cellular Sensitivity to Silver Nanoparticle Toxicity by the Nrf2-Heme Oxygenase-1 Pathway
- The Ameliorating Effect of Oroxylin A Derivatives Against Drug-Induced Cognitive Dysfunction and Prepulse Inhibition Deficit in Mice
- Determination of Esculin in Rat Plasma by High Performance Liquid Chromatography-Fluorescence Detector and UV Detector
- The Flowers of Inula japonica Alleviates the OVAinduced Airway Inflammation in a Murine Model of Asthma
- EBM-15 Attenuates Allergic Airway Inflammation in Ovalbumin (OVA)-induced Murine Asthma Model
- Anticonvulsant Effect of Main Constituents of Artemisia Capillaris Herba in Mice
- Magnolia officinalis and 4-O-Methylhonokiol Increase the Hair-fiber Length of Vibrissa Follicles
- FTY720 (fingolimod) Efficacy in an Animal Model of Multiple Sclerosis Requires Astrocyte Sphingosine 1-Phosphate Receptor 1 (S1P1) Modulation
- Antioxidant Activities and Anti-tyrosinase Activity of Tribulus terrestris
- Neuroprotective Effect of Compounds from Root of Clamatis against OGD and Dopamine-induced Cell Death
- Antitumor Effect of Isorhamnetin, a Flavonoid Isolated from Artemisiae Capillaris, on the Cell Cycle Arrest and Apoptosis in HCT 116 Human Colon Cancer Cells
- Inhibitory Effect of Novel ALK5 Inhibitor on Breast Cancer Metastasis to Lung
- UVA-mediated Pin1 Induction is Involved in Cell Proliferation and Malignant Transformation of Epidermal Cells
- Metabolism of Arctiin by Korean Intestinal Microflora and Its Memory-Enhancing Effect
- Anti Cancer Effect of Bee Venom Toxin and Melittin in Ovarian Cancer Cells through Induction of Death Receptors and Inhibition of STAT3 Pathway
- Asymmetric Synthesis of D- and L-ribo-Phytosphingosine
- Inhibitory Effects of Dihydroartemisinin on PMAInduced Inflammatory Response in RAW264.7 Macrophages
- Clopidogrel Significantly Affected the Pharmacokinetics of Sibutramine and Its Active Metabolites
- Potent Inhibition of Cytochrome P450 2B6 by Sibutramine in Human Liver Microsomes
- Assessment of Availability on Combination Chemotherapy with 5-FU and WK6, Immune-stimulating Herb Extract, Combination in Colorectal Cancer
- Changes in Expression of Hepatic Antioxidant Enzymes in Rat Inhaled with Carbon Nanoparticles
- L-Serine Attenuate Steatosis by Suppression of Hyperhomocysteinmia
- Cilostazol, a Phosphodiesterase Inhibitor Attenuates Endotoxin Shock and LPS-induced Inflammation by Independence of cAMP, MAPK, and NK-kappaB Mechanism
- Inhibition of Cardiac Ion Channel Currents by Amitriptyline
- Characteristic of Prenatal Valproate Exposure-Induced Autistic Symptoms in Sprague-Dawley Rats
- Suppressive Effect of JI830 on Lipopolysaccharide-Induced Nitric Oxide Synthesis
- Evaluations of Anticancer Effect of MHY412 in Doxorubicin- Resistant Human Breast Cancer MCF-7/Adr Cells
- Protective Effect of Perilla frutescens cv.Chookyoupjaso Mutant Water Extract on Gamma-Ray-Induced Oxidative Stress in Mice
- Inhibitory Effect of Thymus- and Activation-Regulated Chemokine and Intercellular Adhesion Molecule-1 Expression by Pleurotus eryngii in Human Keratinocytes
- Antiplatelet Activities of the Extracts of Zizyphus jujuba
- Simultaneous Analysis of Tetrahydrobiopterin (BH4) and Dopamine by Using Liquid Chromatography Coupled Electrospray Tandem Mass Spectrometry
- Formulation of Drug Containing Pseudoephedrine and KOB
- Inhibitory Effect of Resveratrol on Production and Secretion of Airway Mucin
- Effects of Korean Red Ginseng Extract on Immune Modulation and Anti-oxidation in Human Keratinocytes
- Experimental Studies on the Hair Growth Activity of Herbal Extracts in C57BL/6 Mice
- Metastasis Associated Antigen 1 Mediated Regulation of ER Transcription Involves a TFAP2C Binding Region in the ER Promoter
- The Inhibitory Effects of Water Extracts, Trichosanthes Kirilowii and Pogostemon Cablin Bentham on Inflammatory Process in vitro and in vivo
- Characterization of Autophagic Cell Death Mechanism in Two Different Dopaminergic Neuronal Models
- Sphingosine-1-phosphate Regulates the Matrix Metalloproteinase-9-mediated Breast Cell Invasion through S1P3-Gαq Coupling
- Anti-inflammatory Action of Lonicerae Flos HS-23 on LPS-activated Primary Macrophages from C57BL/6 Mice
- Epigenetic Reprogramming of Genes Assoiciated with Multipotency and Lineage Specification by Reversine
- Red Ginseng Extracts Exerted Strong Estrogenic Effects in MCF-7 Cells
- Hypoxia-Inducible Factor 1 Alpha Induces Estrogen Receptor Alpha mRNA Repression in Human Breast Cancer Cells
- DDA3 Associates with MCAK and Controls Chromosome Congression
- In vivo Activation of ROCK1 by Insulin is impaired in Skeletal Muscle of Humans with Type 2 Diabetes
- FHAP Induces Apoptosis in Human Endometriotic Cells via the Inhibition of NFκB Pathway
- Co-treatments of Paclitaxel with Quercetin Enhanced Anticancer Activity Through Cell Cycle Disruption in MCF-7 Cells
- Regulation of Histone H3 Lysine9 Methylation by Tumor Suppressor Menin
- A Comparison of Viral RNA-Dependent RNA Polymerase between BVDV and HCV
- Flavonoid High Fraction of Artemisia Princeps (FHAP) Induce G2/M Cell Cycle Arrest in Human Endometrial Cancer Cells
- Sp1 Transcription Factor Regulates Transcription of Metastasis-associated 1 Gene
- A Newly Synthesized Strong Tyrosinase Inhibitor : MHY-508
- KBH-A145, a Novel Gamma-Lactam-Based Histone Deacetylase Inhibitor, Suppresses the Growth of Human Breast and Renal Cancer
- Inhibitory Action of Saucerneol D on cAMPInduced Melanin Production in B16 Cells
- Xanthohumol from Hop Plant Stimulate Osteoblast Differentiation by Runx2 Activation
- ERK1/2 Regulates Osterix during Osteoblast Differentiation
- In vivo Distribution of Antitumor Effector T Cells ex vivo Expanded with Anti-CD3 Antibody and IL-2
- Peroxiredoxin II Modulates ROS-related Signaling during LPS-induced Osteoclatogenesis
- Antioxidant Compounds Isolated from Cynanchum wilfordii
- An Unprecedented Cyclobutane-Bearing Macrocyclic Lactam from the Dung Beetle-associated Streptomyces sp.
- Comparison of Dual Coated (Duolac™) and Uncoated Lactic Acid Bacteria from Potential Probiotics
- Conditions for Formation of Synnemata from Entomopathogenic Fungi (Beauveria bassiana)
- New Phenyl-Pyridines from the Dung Beetle-Associated Streptomyces sp.
- Comparison of Cytotoxic Mechanism of Antitumor Effector T cells, Natural Killer Cells, and Cytokine-induced Killer Cells
- Development of Antibody Drug for New Target Protein Related with Ovarian Cancer
- Effects of Aging on the Induction of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice
- Inhibitory Effect of Deguelin on Tumor Vasculogenesis through Suppressing Proliferation and Functions of Endothelial Progenitor Cells
- Differential Effects of Indoles and Serotonin on Inflammatory Response in HT-29 Colon Epithelial Cells
- Development and Cultivation of Paecilomyces tenuipes, Medicinal Mushroom Isolated in Korea
- Identification of a Novel Class of Small Molecules as MDR Reversal Agents
- Epigenetic Regulation of Embryonic Stem Cell Signature in NCCIT Cells
- Endogenous IKKβ in Microglia is Essential for Hippocampal Neurogenesis
- A Novel Nrf2 Activator, N12 Decreased Neuronal Loss and Neuroinflammation in the MPTP-induced Parkinson's Disease Model
- Insulin-like Growth Factor Binding Protein-3 Suppresses VEGF Expression and Inhibits Head and Neck Squamous Cancer Cell Angiogenesis
- Peptide Binding to Dimerized Translationally Controlled Tumor Protein, Decreases Cytokine Release and Modulates Inflammatory Reactions
- Antioxidizing Effect and Antimicrobial Activities of Saponins from Kalopanacis Cortex (Kalopanax pictus), Soybean (Glycine max) and Ginseng (Panax ginseng).
- A Fermented Ginseng Extract, BST204, Inhibits Proliferation and Invasion of Human Colon Cancer Cells via Mediation by Rh2
- Induction of Peroxiredoxin Expression in RBL-2H3 Basophilic Mast Cells Cultured in Jeju Water
- hSalvador and MST2 Regulate Estrogen Receptor Alpha
- Bahamaolide, a Novel Antifungal-macrocyclic Lactone from the Marine Actinomycete, Streptomyces sp.CNQ343
- Six New Germacranolide Sesquiterpene Lactones from Dendranthema zawadskii var. latilobum
- Expression of Prostacyclin Synthase and Receptor in Chemoresistant Human Ovarian Cancer Cells
- Gamma-Secretase-Mediated Notch Signaling Induces Neuronal Cell Death via the NFêB-Bim Pathway in Ischemic stroke
- Identification of H-Ras–Specific Motif for the Activation of Invasive Signaling Program in Human Breast Epithelial Cells
- Cytotoxic Effect of Interleukin-32 in Natural Killer Cells
- Glycyrrhizic Acid Inhibits KSHV Latency by Glycyrrhizic Acid Inhibits KSHV Latency by Docking Site
- Tectorigenin Inhibits the Akt/NFkB Signaling Pathway in Paclitaxel-resistant Human Ovarian Cancer Cells
- Recently Cosmetics Policy Direction
- Fluorescent Phosphoinositide 3-Kinase Inhibitors Suitable for Monitoring of Intracellular Distribution
- Effect of Curcumin on Vibrio vulnificus Infection
- Isolation and Structure Identification of Chemical Isolation and Structure Identification of Chemical
- Rh-catalyzed Oxidative Carbonylation of Benzamides with Aldehydes: Direct Functionalization of sp2 C-H Bond
- Structure Activity Relationship of Lipophilic Chalcones as Antagonists of Endotoxin LPS-induced TLR4/ MD2
- (+)-3-Hydroxymorphinan Derivatives as Neuroprotectants
- Structure-based Drug Discovery of a Secondgeneration Androgen Receptor Antagonist for Treatment of Advanced Prostate Cancer
- Catalytic Carbon-carbon Bond Formations: Enantioselective Total Synthesis of (+)-Fluvastatin
- Synthesis of Aurones and Their Biological Evaluation
- First Total Synthesis of Iridoid 6-Hydroxy-7-(hydroxymethyl)-4-methylenehexahydrocyclopenta [c]pyran-1-(3H)-one via Pd(0)-catalyzed Allylic Alkylation
- Antioxidative Components from the Whole Plants of Veronica peregrina
- Structure Activity Relationship of Chromone Analogs for the Inhibitory Aactivity of Iinterleukin 5
- Simultaneous Analysis of Bioactive Metabolites from Rehmannia Radix Preparata by HPLC-DAD-MS/MS
- Structure-activity Relationship Studies of Novel Arylsulfonylimidazolidinones for Their Anticancer Activity
- Structure Comparison of Human S-adenosylhomocysteine Hydrolase and Computational Studies with Its Novel Mechanism-based Inhibitors, Halo-neplanocin A’s
- Antimicrobial Activity of Marine Sponge Derivedfungus Strains against Multidrug Resistant (MDR) Strains
- Design, Synthesis and Docking Study of 5-Amino Substitued Indeno[1,2-c]isoquinolines as Novel Topoisomerase I Inhibitors
- Triticum aestivum Sprout Extracts Reduce Diabetic Signs in Leptin Deficient ob/ob Mice
- Antioxidative Activity of Identified Bacillus Strain-Fermented Saururus Chinensis
- Mechanism Study of Therapeutic Anti-tumor Effect by Intratumoral Injection of Recombinant Attenuated Salmonella Vaccine Strain
- Antioxidative Activity of Identified Microganismfermented Microganismfermented
- Characterization of Myeloid-Derived Suppressor Cells in Myd88-/- or IL-1R-/- Mice
- Activation of Mutagenicity of Rutin by Fecalase and Intestinal Microbial Enzyme Mixture in Ames Test
- Evaluation of Prophylactic Antibiotic Use in Patients with Cardiovascular Surgery
- Sesterterpene Sulfates from the Tropical Sponge Dysidea sp.
- Concise Synthesis of (±)-Grandisol: Regioselective Pd(0)- Catalyzed Intramolecular Allylic Alkylation for Cyclobutane
- Discovery of New Azaindole-based PI3Kα Inhibitors: Apoptotic and Antiangiogenic Effect on Cancer Cells
- Dynamic Analysis of Pathogen-infected Host Cells Using Quantitative Phase Microscopy
- Asymmetric Synthesis of Hydroxywilfordic Acid, Pyridine-containing Subunit of Anti-HIV Sesquiterpene Pyridine Alkaloids
- Rapid Identification and Evaluation of Antioxidant Compounds from Extracts of Petasites japonicus by Hyphenated-HPLC Technigues
- Synthesis and Some Properties of Lipophilic 4'-Groups in 5'-Norcarbocyclic Nucleosides on Antiviral Activities
- Efficient and Unified Strategy for Benzo[α]- quinolizidine Alkaloid Syntheses: Stereoselective Total Synthesis of (-)-Protoemetinol
- Identification of Potent Dual EGFR/KDR Inhibitors
- Syntheses and Chemopreventive Activities of Diyne Natural Products
- Highly Enantioselective Synthesis of α,α–Dialkylmalonates by Phase-transfer Catalytic Desymmetrization
- Isolation and Biological Activities of Sesquiterpenes from Thujopsis dolabrata
- Synthesis of Bis-amides Derivatives by Ugi Four Component Condensation
- Total Synthesis of Anti-asthmatic Pyranopyrandione Derivatives
- Total Synthesis of Ochnaflavone Analogs Having CNH-C and C-S-C Linkages
- Synthesis and Biological Properties of Benzoannulated Tryptanthrin
- Diketopiperazines and Phthalides from a Marinederived Fungus Acremonium strictum
- Synthesis of Salicylamide Analogues with Inhibition Activity of Epidermal Growth Factor Receptor(EGFR) Tyrosine Kinase
- Total Synthesis of Polyoxygenated Indolizidine Alkaloid as Glycosidase Inhibitor
- Total Synthesis of (+)-Valienamine via Stereoselective Amination with Chlorosulfonyl Isocyanate
- 4-Piperidinecarboxylate and 4-Piperidinecyanide Derivatives for T-type Calcium Channel Blocker
- Design and Synthesis of 2-Benzyl and 2-benzoylpyridine Analogs for Selective Chymase Inhibitors
- Rapid Analysis of Betula platyphylla Using Near-Infrared Spectroscopy (NIR) and Multivariate Analysis
- Chromone Glycosides from the Fruits of Cnidium monnieri
- Full Assignments and Revision of the 1H and 13C NMR Data of Jujubosides A and B, the Two Major Saponins from the Seeds of Zizyphus jujuba Miller
- Cinchona-derived Ammonium Salts-catalyzed aza Diels-Alder reaction of Danishefsky’s Diene with Imines
- Phytochemical Analysis of Phenolic Compounds in 30% Ethanolic Extracts from the Compositae Plants and Peroxynitrite-scavenging Effect
- Anti-oxidative and Anti-obesity Activities of Fourhundred Extracts Isolated from Natural Products Libraries
- Protective Effects of Buckwheat against Oxidative Stress and Gastric Cancer
- Effects of Medicinal Herbal Formula (JDK) on Appetite and Body Weight Control in High Fat Diet-induced Obese Rats
- Limonoids and Triterpenoids from Melia azedarach
- Anti-microbial Activity of AC-care, a Composition of Herbal Extract, Against Propionibacterium Acne
- Antibacterial Metabolites from a Jellyfish-derived Fungus Paecilomyces variotii
- Royal Jelly Reduces Melanin Synthesis through Down Regulation of Tyrosinase Expression
- Aqueous Extracts of Liriope platyphylla are Tightlyregulated by Insulin Secretion from Pancreatic Islets and by Increased Glucose Uptake through Glucose Transporters Expressed in Liver Hepatocytes
- The Development of HPLC-DAD Method for Simultaneous Determination of Eight Major Components in the Traditional Herbal Prescription, Sipjundaebo-tang
- Neuroprotective Effect of Herbal Medicines in Neuronal Cells
- Conjugation of Ginsenoside Rg3 with Gold Nanoparticles
- Ophiobolin B Inhibits Human Glioblastoma U87MG Cells Proliferation by Inducing S Phase Arrest and Apoptosis
- Effect of Scoparone from Artemisia capillaris on Smooth Muscle of Rabbit Penile Corpus Cavernosum
- Constituents of Dendranthema zawadskii var. latilobum and Their Inhibitory Activities on NO Release in LPS-stimulated RAW 264.7 Macrophage
- The Anti-oxidative and Anti-inflammatory Effect of Phenolic Compounds from the Leaves of Cleyera Japonica Thunb.
- Evaluation of the Remedy for Neuronal Diseases from Rhemannia glutinosa Liboschitz and Elucidation of their Underlying Mechanisms.
- Discrimination of Artemisia princeps Based on Ultra Performance Liquid Chromatography
- Pharmacognostical Studies on the Korean Folk Medicine "ORiNaMu"
- Pharmacognostical Studies of the 'Kilkyung'
- Pharmacognostical Studies on the Folk Medicine 'SaCheolNaMuIp'
- Therapeutic Effects of Distillated Medicinal Herb Mixtures on NC/Nga Mouse Model of Allergic Dermatitis
- Anti-inflammatory Effect of Ixeris dentata on Utraviolet B-induced Human Immortalized Keratinocytes Cell Line HaCaT Cells
- Extracts of Twigs of Actinodaphne lancifolia Cause Nrf2-mediated Induction of Quinone Reductase
- Phytochemical Constituents of Abutilon theophrasti
- The Inhibitory Effect on Aldose Reductase by an Extract of Prunella vulgaris
- Phenolic Compounds from the Stem of Viburnum erosum
- HMP-1004 Prevent Scopolamine-induced Memory Impairment in Mice
- Protective Effects of CGX on Alcohol Induced Chronic Liver Injury in Rats
- Anti-angiogenic Effects of Honokiol, a Neolignan from Magnolia obovata, in Mouse Embryonic Stem Cellderived c
- Protective Effect of Cimicifuga heracleifolia Ethanol Extract and its Constituents on Gastritis and Gastric Lesions
- Crude Extracts of Curcuma longa L. Inhibit IL-6 Induced Stat3 Activation
- Eye Drops of FK506 and Its 3 Prodrugs Based on Chitosan to Iimprove Solubility and Retention Time
- Identification of a New Flavanoid from Citrus unshiu
- Acetylcholinesterase Inhibitors from the Whole
- Biological Effects of the Leaves and Roots of Ligularia stenocephala
- Effect of Citri pericarpium Extract on Serum Lipid Profiles in subject by a Randomized, Double Blind, Placebocontrolled Clinical Trial
- Anti-cancer Effect of Quercetin Glycosides Isolated from the Flowers of Hamamelis japonica
- Asteropusin A, a New Cystine Knot Peptide from the Marine Sponge Asteropus sp.
- Antifibrotic Constituents from the Stem Barks of Broussonetia kazinoki
- Leejung-tang, a Traditional Herbal Formula Reduces Ethanol-induced Acute Gastric Injury in Rats
- Advanced Glycation Endproducts Inhibitors from Artemisia capillaris Thunb.
- DNA Topoisomerase Inhibitory Activity of Constituents from Polygonum aviculare L.
- Anticnacer Constituents from the Aerial Part of Selaginella tamariscina
- Pregnane Glycosides from Cynanchum atratum
- Cytotoxicity of Herbal Medicines in Human Colon Cancer Cells
- Inhibition of Prostaglandin-D2 Production by Trihydroxy Fatty Acids Isolated from Ulmus davidiana var. japonica.
- Neuroprotective Effects of INM-176 against Aβ1-42-induced Neuronal Toxicity in Mice
- Preparative Isolation of Flavonoids and Stilbenes from Ivy Stems (Parthenocissus tricuspidata) by Centrifugal Partition Chromatography
- Structural Analysis of Sur2391-582, the Minimal Binding Core of ESX
- Liquid Chromatography-electrospray Ionization Tandem Mass Spectrometry for Quantification of Styraxlignolide A in Rat Plasma
- Determination of Biogenic Amines as Their Benzoylated Derivatives by Dispersive Liquid-liquid Microextraction with Solidification of Floating Organic Droplet Followed by HPLC-UV
- Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Compounds from Prunella vulgaris
- Characterization of Fragrance from Convallaria keiskei Miq. by Gas Chromatography-Mass Spectrometry
- Monitoring of Bioactive Marker Compounds from Eucommiae Cortex by HPLC
- Determination of Bepotastine in Rat Plasma by High Performance Liquid Chromatography with Electrospray -Tandem Mass Spectrometry and Its Application to Toxicokinetic Study
- Optimizing Conditions for the Extraction of Polyphenol in Purple Corn (Zea may) Using Response Surface Methodology
- Non-destructive Analysis Pharmaceuticals in Capsules Using Raman Spectroscopy
- Validated Method for the Quantification of Gastrodin in Different Processed Products of Gastrodia elata Blume
- The Near-infrared (NIR) Monitoring of the Indomethacin Agglomerate Process by Spherical Crystallization
- Screening for μ-Calpain and Cathepsin Inhibitors from Natural Herbal Extracts
- Chromatographic Enantiomer Separation for Amines or Amino Alcohols as 9-Anthraldehyde Schiff Base Derivatives Using Polysaccharide-derived Chiral Stationary Phases
- (−)-Epigallocatechin-3-gallate Ameliorates Lipopolysaccharide- induced Elevation of beta-amyloid Generation and Memory Deficiency via Inhibition of Neuroinflammation
- Free Radical Scavenging Activities and Nitric Oxide Generation Inhibitory Activities of Extracts from Natural Herbs with Extract Conditions
- Inhibitory Effect of Ginsenoside F2 in the Development of Dermatophagoides Farinae-induced Atopic Dermatitis in NC/Nga Mice
- The Antioxidant Activity of Galloyl Flavonoid Derivatives from the Leaves of Myrica rubra
- Antifibrotic Effects of Juglans sinensis Extract against CCl4-induced Liver Fibrosis in Rats
- Establishment of the Criterion for Contents of Marker Compound in Herbal Drug
- Analytical Methods for Determining Active Ingredients of Mosquito Incense Products
- Chemical Pattern-aided Classification for Rhei Rhizoma Using Chromatographic Fingerprinting and Pattern Analysis
- Sitagliptin Attenuates Metformin-mediated AMPK Phosphorylation through Inhibition of Organic Cation Transporters
- Formulation Design and Evaluation of Dissolution Mechanism on Sustained Matrix Tablets containing Tianeptine Sodium
- Effect of PEGylation on the Cytotoxicity and Bioactivity of Pentapeptide
- Design and Physicochemical Characterization of Osmotically Controlled Tablet
- Elution Order for Enantiomers of Some Decursin Derivatives Separated on Cellulose Based Chiral Stationary Phase Chiralcel OJ-H by High Performance Liquid Chromatography
- Development and Biopharmaceutical Evaluation of Curcumin Using Self-emulsifying Drug Delivery System (SEDDS)
- Effects of Processing Methods and Decoction Waters on the Extraction of Ginsenosides from the Leaves of Panax ginseng
- Establishment of Analytical Methods of Bioactive Marker Compounds from Achyranthis radix by HPLC
- Prediction of Human Pharmacokinetic Profile of SKL11197 in Animal Scale Up Based on Normalizing Time Course Profiles
- Inhibitory Effects of Ketoconazole and Rifampin on OAT1 and OATP1B1 Transport Activities: Considerations on Drug-Drug Interactions
- Pharmaceutical Potential of Human Serum Albumin Nanoparticles Surfaced-modified with TNF-related Apoptosis Inducing Ligand (TRAIL) as a Pulmonary Delivery System
- Application of Simply Modified HPLC Method in Evaluating Pharmacokinetic Parameters of Paclitaxel
- Preparation and Characterization of Long-acting Intrapulmonary Delivery System using Chitosan Nanogels for Treating Type 2 Diabetes
- Docetaxel Self-emulsifying Drug Delivery System (SEDDS) for Enhanced Solubility and Oral Bioavailability
- Bioequivalence of Terbin？？ Tablet to Lamisil？？ Tablet (Terbinafine Hydrochloride 125 mg)
- Dual Delivery of Mitoxantrone Derivatives-based Nanoparticles
- Development of Surface-engineered Liposomes Containing Sirolimus by Lipid Film Hydration Method for Lymphatic Delivery
- Enhanced Oral Bioavailability of Docetaxel by Treatment with Verapamil
- Enhancement of Solubility of Docetaxel Using Prodrugs and Formulations
- A Study on the Terms of the Indication of the Approved Drug's Label
- Decursin Regulated Sphingosine Kinase Activities in Human Umbilical Vein Endothelial Cells
- Cellular Uptake, Lymphatic Uptake and In Vivo Study of Paclitaxel Loaded Solid Lipid Nanoparticles with HPCD
- Novel Flurbiprofen-loaded Nanoparticles Formulation and Improved Bioavailability with PVP Using SPG Membranes and a Spray Drying Technique
- Variation of Glomerular Filtration Rate by Concomitant Drugs in Patients with Coronary Angiography
- Preformulation Study of Tacrolimus Prodrugs to be Developed for Increasing Aqueous Solubility
- Singnal Detection of Drug Interaction of Tamiflu in Korean National Health Insurance Review Database
- Patient’s Experience and Perception on Pharmacist’s Consultation Services: An Exploratory Study
- Effects of Inflammatory Cytokine Gene Polymorphisms on Bleeding Complications in Patients with Warfarin Therapy
- Establishment of Pharmacogenomics Management System for Drug Evaluation
- Other Additive System without Individual Scheduling for Controlled Substances
- Changes of Anti-inflammatory Activity of Gardeniae Fructus by Processing
- Study of the Fermented Dioscorea batatas (Yam) Extracts on the Activation of Macrophage
- Anti-inflammatory Effects of Sulfuretin from Rhus Verniciflua Stokes via the Induction of Heme Oxygenase-1 Expression in Murine Macrophages
- Neuroprotective Effects of the Extract of Water-Insoluble Portion of the Zingiberis Rhizoma 70% EtOH Extract
- Modification and PPAR Gamma-binding Activity of Marine derived Phthalide
- Simultaneous Determination of Six Marker Compounds in Ohyaksungisan by HPLC-DAD
- Neuraminidase Inhibitory Activities of Flavonols Isolated from Rhodiola rosea Roots and Their In Vitro Antiinfluenza Viral Activities
- Anti-inflammatory Effect of Clematis mandshurica in LPS-induced RAW 264.7 cells
- New Phenylethanoid Gycosides from Digitalis purpurea L.
- Characterization of Humic and Fulvic Acids Extracted from Humic Substances
- New Diaryheptanoids Isolated from Alnus hirsuta var. sibirica Leaves
- Studies of the Constituents from the Whole Plants of Geum japonicum
- Difference of Metabolic Pharmacokinetics between Pure Amygdalin and Amygadalin in Decoction of Peach Seed in Rat
- Development of a Simple and Sensitive HPLC-MS/ MS Method for the Determination of Fexofenadine in Human Plasma
- Fluorescence-based Screening for Glucose Uptake to Identify Anti-diabetic Korean Indigenous Plants
- Protective Effect of COR against Ototoxicity by Cisplatin in Mice
- Petrosiacetylenes from the East Sea Marine Sponge
- Efficacy Evaluation of Chlorella vulgaris Extract Mixed Juices on Prevention of CCl4-induced Hepatitis in Rats
- Identification of Alkaloids in Corydalis Species Using Liquid Chromatography-electrospray Ionization Tandem Mass Spectrometry
- Development and Evaluation of a Sensitive HPLC Assay Method for the Determination of Phytonadione in 5% Phytonadione Powders
- Determination of Nizatidine in Human Plasma by LC-MS/MS and Clinical Pharmacokinetic Studies
- Simultaneous Determination of (-)-Menthone and (-) -Menthol in Menthae Herba by Gas Chromatography and Principal Component Analysis
- Analytical HPLC-UV Method for the Determination of Metoclopramide in Human Plasma and Its Application to a Pharmacokinetic Study
- Determination of Valsartan in Human Plasma Using a HPLC Method with Fluorescence Detection and Its Application to a Pharmacokinetic Study
- Simultaneous Analysis of Volatile Organic Compounds in Alcoholic Beverages Using Headspace-gas Chromatography/Flame Ionization Detector
- Physical Characteristics of Decoction Water and Component Extraction Effect of Gardeniae Fructus
- Preparation and Characterization of Liquid Alginateraft Formulation
- Determination of Entecavir in Human Plasma by High Performance Liquid Chromatography with Tandem Mass Spectrometry
- 3’,4’,7-Trihydroxyflavone Inhibits Hydrogen Peroxide-Induced Apoptosis via Phosphorylations of MAPKs and PI3K/Akt in SH-SY5Y Cells
- Effects of Combined Treatment of Mixtures Including Medicinal Herbs on the Hair Growth in C57BL/6 Mice
- Novel Solid Self-Microemulsifying Drug Delivery System(SMEDDS) for Enhanced the Solubility of Fenofibrate
- Preparation, Characterization and Optimization of Flurbiprofen Loaded Liquid SNEDDS Formulation by Using Box-Behnken Design and Desirability Function
- Design and Evaluation of Sustained-release Multilayer Pellets containing Dexibuprofen
- Effects of Cysteine on the Pharmacokinetics of Etoposide in Rats with Protein–calorie Malnutrition
- Preparation and Characterization of Gemcitabine Microparticles for Oral Delivery
- Sequential Delivery of Dual Drug from PLGA Microspheres for Effective Combination Cancer Therapy
- Permeation Enhancement Study of Microemulsion Systems to Improve Iontophoretic Delivery of Calcitonin
- Cubosome Formulation Containing Finasteride for Topical Application: Preparation, Characterization and Invitro Study
- Formulation of Sustained-release Tablets Containing Nimodipine Solid Dispersions
- Development and Validation of Dissolution Test for Midodrine HCl Tablets in Korean Pharamceutical Codex
- Cubosome Formulation for the Intradermal Delivery of Tacrolimus: Preparation, Characterization and In-vitro Study
- Novel Membrane Emulsification System for Enhanced the Solubility of Itraconazole
- Differential Induction of MDR1 and CYP3A4 by Taro Compounds, T-2000 and Its Major Metabolites, T-2001 and DPB, in LS180 and not Caco-2 Cells
- Effects of Resveratrol on the Bioavailability and Pharmacokinetics of Losartan in Rats
- Test Method of Absorbing Power for the Hydrophilic Dressings
- Background of Introduction of an Emergency Procedure for Controlled Substances
- Drug-drug Interactions between Traditional Herbal Medicines and Chemical Drugs for Diabetes Mellitus
- Evaluation of the Effects of Storage Conditions on the Stability of Porcine Placenta Extract-loaded Liposome Formulations
- Positive Effects of Haematococcus Astaxanthin on Lipid Profile in Overweight and Obese Adults
- Formulations of Isradipine for Sustained Release and Enhanced Oral Bioavailability : In Vitro and in Vivo Evaluation Among the Healthy Volunteers
- Evaluation of Safety and Efficacy of Carnosine, a Neuroprotective Agent against Ischemic Sroke
- Pharmacokinetics and Drug Metabolism of Decursin and Decursinol as a New Drug Candidate
- Relative Influences of MDR1, PEPT1 and OCTs to the Pharmacokinetics of Levosulpiride in Korean Subjects
- Population Pharmacokinetic Analysis of Cilostazol in Healthy Korean Subjects
- Butein from Rhus verniciflua Protects Pancreatic β Cells against Cytokine-induced Toxicity Mediated by Inhibition of Nitric Oxide Formation
- Isolation and Biological Activity of Mitochondrial Glycerol-3-phosphate Acyltransferase Inhibitor from Aralia cordata
- In Vivo Imaging Agents Based on Flavonoids for Amyloid's Plaques in the Brains of Patients with Alzheimer's Disease
- Synergy Effect of Apigenin and TRAIL in HepG2 Cells is Associated with Induction of Reactive Oxygen Species
- Pharmaceutical Reimbursemet and Pricing Policies in Korea
- Effects of Alkaline Phosphatase Inhibitors for the Stabilization of Different Ester of Ascorbic Acid 2 Phosphate Salt In Vitro Study
- REMS Sets Higher Bar for Drug Safety: REMS/RMA System in USA, EU and Its Implication in Korea
- Structure-activity Relationship Study of Moracins O and P Analogues as Potential HIF-1α Inhibitor
- A Comparative Study on Scratching Behavior of Taraxacum coreanum Nakai. and T. officinale WEB. Extracts
- SB 365 Isolated from Pulsatilla koreana Inhibits Gastric Cancer Progression by Inducing Apoptosis and Inhibiting Angiogenesis
- A Novel Orally Bioavailable Dual PI3K/mTOR Inhibitor, HS-104, Suppresses Growth and Induced Apoptosis in Breast Carcinoma Cells and Nude Mouse Xenografts
- Increases in Blood Pressure and Heart Rate Induced by Caffeine are Inhibited by (-)-Epigallocatechin-3-O-gallate: Involvement of Catecholamines
- Effects against Mercury Chloride-Induced Nephrotoxicity by Activated Cultivated-Wild Ginseng in Rats
- Bisabolangelone Inhibits cAMP-induced Melanin Production in B16 Melanoma Cells via Blocking Dissociation of Catalytic Subunit from Regulatory Subunit of PKA
- In-line Monitoring of Fluid-bed Granulation Process and Determination of Quality Attributes by NIR Spectroscopy
- FAG Inhibits Lipopolysaccharide Induced-iNOS Expression and Activity of NF-kB in Macrophage
- Disease Biomarker Discovery and Validation Using Mass Spectrometry
- 135B from Typha angustata Inhibits Vascular Smooth Muscle Cell Proliferation via G0/G1 Arrest
- Determinants of Pharmaceutical Expenditure in National Health Insurance: Policy Implication of the Analysis
- Effect of Physicochemical Properties of Drug and Pressure Sensitive Adhesives on Transdermal Drug Delivery
- Paroxysmal Extreme Pain Disorder Mutation in Voltage Sensor of Nav1.7
- PKC-δ Inhibitors Sustain Self-renewal of Mouse Embryonic Stem Cells under Hypoxia In Vitro
- Preparation and Properties of Lamellar Liquid Crystal: Effect of Hydrophilic Polymers
- Effects of Gastrodia Elata Bl on the Cocaine-Induced Neuropsychotoxicity in Mice
- Direct and Metabolism-dependent Cytochrome P450 Inhibition Assays for Evaluating Drug-Drug Interactions
- Transdermal Delivery of Donepezil: a Feasibility Study
- Anti-inflammatory and Anti-allergic Effects of Cinnamomum cambodianum Lecomte Collected in Cambodia
- Drug Metabolite Identification and Profiling Using LC/MS
- Estrogenic Activities of Dandelion Extracts
- A New Paradigm for Stem Cell Therapy: Stem Cell Mobilization for Tissue Repair
- An Upstream Regulatory Mechanism of Tumor Suppressor Menin
- Functional Role of Mixed Lineage Kinase 3 (MLK3) on Osteoclastogenesis
- Effects of Anti-inflammatory Anthraquinones from Rhubarb on P-glycoprotein-mediated Drug Efflux in Caco-2 Cells.
- Characterization of Polymer-based Solid Dispersions Containing Poorly Water-soluble Cilostazol
- Preparation and Characterization of Inhalable Doxorubicin-loaded Porous Poly (Lactic-co-Glycolic Acid) Microspheres for Treating Lung Cancer
- Development of Innovative Biomedicine: A Case Study on Cardiovascular Gene Medicine Using Naked DNA Expressing Two Isoforms of Hepatocyte Growth Factor
- Evaluation of P-glycoprotein Inhibitory Activity of Naturally Occurring Compounds
- YC-1 Enhances Natural Killer Cell Differentiation from Hematopoietic Stem Cells
- Anti-metastatic Activity of Pinosylvin, a Natural Stilbenoid, is Associated with the Suppression of MMPs
- Slower Clearance of ε-Acetamidocaproic Acid in Rats with Acute Renal Failure Induced by Uranyl Nitrate
- Mechanism of 6-Hydroxydopamine-induced Cytotoxicity by Cyclic AMP-Bad Signaling Pathway in PC12 Cells
- Receptor-oriented Pharmacophore-based in Silico High-throughput Screening in Drug Design
- Influenza Virus Neuraminidase Inhibitory Activity of Phlorotanins from the Edible Brown Alga Ecklonia cava
- Sibutramine Base-loaded Solid Dispersion with Gelatin and HPMC: Physicochemical Characterization and Pharmacokinetics in Beagle Dogs
- Kamebakaurin Inhibits Lipopolysaccharide-induced Dendritic Cell Maturation via the Downregulation of TAK1-NF-kappaB Pathway
- Anti-Fibrotic Effects of EW-7197, a Novel Transforming Growth Factor-β Type I Receptor Kinase (ALK5) Inhibitor on Bile Duct Ligation-induced Liver Fibrosis in Rats
- Free Fatty Acids Induce Lipoapoptosis in HepG2 Cells
- Development of a Sensitive High-performance Liquid Chromatography-tandem Mass Pectrometry Assay for the Eetermination of [6]-gingerol in Mouse Plasma: Application to a Pharmacokinetic Study
- Anti-proliferative Activity of Methanol Extract from Larrea cuneifolia Cav. on Breast Cancer Cell Lines
- Neuroprotective Effect of the Water-insoluble Fraction of Root Barks of Dictamnus dasycarpus 70% Ethanolic Extract on Glutamate-induced Oxidative Damage in Mouse Hippocampal HT22 Cells
- Fluoroquinophenoxazine Derivative as an Antiproliferative Agent in Gastric Cancer Cells and Potential Dual Inhibitor of Human Epidermal Growth Factor Receptor 2 and Topoisomerase IIα
- The Role of GSK3β/ β-Catenin Signal in NPC Proliferation and Neurongenesis in the Brain of Rats Prenatally-exposured to Valproic Acid
- Protective Effect of AETO from Dopamine Induced Cell Death by Inhibition of Tyrosinase Activity
- The Inhibitory Effect of the Premature Citrus Unshiu Extract on the Atopic Dermatitis in vitro and in vivo
- HS-1200, a Synthetic Chenodeoxycholic Acid Derivative, Induces Apoptosis in HCT116 Human Colon Cancer Cells
- Indian CRO Industry with Specific Emphasis on Vimta's Capabilities
- Roles of Pharmaceutical Profiling on Drug Discovery and Development
- Apoptosis-triggered Attenuation of Viral Virulence as Rational Design of Live Vaccine
- Sustainability of Health Insurance Financing and the Growth of Pharmaceutical Industry
- Discovery of Novel Androgen Receptor Antagonists and JAK2 Inhibitors through Structure-based Virtual Screening
- Molecular Inflammation Research Center for Aging Intervention(MRCA)
- Pharmaceutical Market and Reimbursement Policies in the National Health Insurance
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