Synthesis and Biological Evaluation of Novel Pyrimidine Derivatives as Potent GPR119 Agonists for the Treatment of Type 2 Diabetes
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- 영문명
- 발행기관
- 대한약학회
- 저자명
- PHAM Tuan Ahn FANG Yuanying YANG Zunhua PARK Haeil
- 간행물 정보
- 『추계총회 및 학술대회』(2012년), 434~434쪽, 전체 1쪽
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- 의약학 > 내과학
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- 발행일자
- 2012.10.24
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- Direction and Current State of the Revision for KP 10th ed.
- Pharmacological Action of Motilione in the Motility of Feline Stomach Circular Smooth Muscle
- Metabolomic Study on Biochemical Monitoring of Physiological States in Biological Fluids
- Structure Activity Relationship Study on a Class of (E)-Phenoxyacrylic Amide Derivatives as Potential HIF-1α Inhibitors
- Discovery of Novel Ochnaflavone Analogs with Strong Inhibitory Activities against COX-2-mediated PEG2 and iNOS-mediated NO Production
- Effect of Herbal Formula in 3T3-L1 Adipocytes on Glucose a Lipid Metabolism
- The Effect of Korean Food Squid Jeotgal, Changnanjeot of Salt Concentration Change on Lipid Metabolism and Ability of Antioxidant on Induced Hyperlipidemia Rats
- Anti-angiogenic Activity of Honokiol in Vascular Vessel Formation of Mouse Embryonic Stem Cell-derived Endothelial Cells via the Suppression of PECAM and MAPK/mTOR Signaling Pathway
- A Comparative Study of Memory Improving Effects of Taraxacum coreanum and T. officinale on Scopolamine-induced Amnesia in Mouse
- Kazinol U from Broussonetia kazinoki Blocks the β-cell Destruction through Suppression of NF-κB activity
- Carnosic Acid and Carnosol Induced Apoptosis through EP4 Signaling in Human Colon Cancer HCT116 Cells
- Lipidomic Changes in Hepatic Lipase Knockout Mice Revealed by Chip-Based Direct Infusion Nanoelectrospray Ion Trap Mass Spectrometry
- Dopaminergic Neuron Differentiation by Epigenetic Regulation
- Rapid in vivo Screening Method for the Anti-melanogenic Activity
- Enzogenol Regulates Insulin Signaling in White Adipose Tissue
- Comparative Study of Silver Nanoparticles and Silver Ion on the Serum Kinetics, Distribution and Excretion in Rats after a Single Oral Administration.
- Expression of tPA in Neural Progenitor Cells; Role in Neurite Extension.
- Understanding the Mechanism for Development of Inflammatory Disease According to Age Advancement through Metabolomic Analyses of EAE Animal Model
- Calmodulin-dependent Kinase II Regulates osterix During Osteoblast Differentiaion
- Synthesis of Novel Threosyl 5'-Deoxyphosphonic Acid Nucleosides
- Segmental Hair Analysis and Estimation of Methamphetamine Use Pattern
- Inhibitory Effect of a 2,4-Bis(4-hydroxyphenyl)but-2-enal Diacetate on Neuroinflammatory Reactions via Inhibition of STAT1 and STAT3 Activation in Cultured Astrocytes and Microglial BV-2 Cells
- Effects of Some Fractions Extracted from Korean Pine Needle on Catecholamine Release in the Rat Adrenal Gland
- Dual Inhibition of Ras/Raf/MAPK and PI3K/Akt/mTOR Signaling Pathways for The Therapy of Pancreatic Cancer
- Glutathione Peroxidase-1 Gene Depletion Exacerbates Memory Impairment Induced by Aging or Methamphetamine
- Unfolded Protein Response Regulated CXCL1/KC Secretion in Intestinal Epithelial Cells.
- Pharmacokinetics of Isoliquiritigenin (isoLQ), a Simple Chalcone Derivative Found in Licorice, in Mice
- The Development of Assay for Human MGAT2 Enzyme Activity in Human MGAT2 Overexpressed Hep3B Cells, and Human and Mouse Intestine Microsome
- Developmental Effects of 5,5-Diphenylhydantoin on Rat Whole Embryo and Embryonic Midbrain Cell Culture
- Single Step Chromatographic Purification of a Novel Thermostable Cellulase Free Endo β-1, 4 XylanaseStable in Broad Range of pH from Streptomyces sp. CS428
- Oral Docetaxel Formulation Using Lyophilized Liposome
- Validation of Cell-based Permeability Assay in MDCK and Caco-2 System Using LC-MS/MS in Early Stage of Drug Discovery
- Physicochemical Properties and Formation Mechanism of Albumin Nanoparticles
- Enhanced Intrapulmonary Administration of Cationic Nanoliposomes for Anticancer siRNA Delivery
- Role of NADPH Oxidase in Redox Regulation of Drug-resistant MCF-7 Human Breast Cancer Cells
- Transcriptional Changes in the Striatum of Spontaneously Hypertensive Rats Showing Addiction-like Response to Amphetamine and Methylphenidate
- 6-Bromoindirubin-3'-oxime as a Novel Agent for Inducing Tissue Regeneration and Cell Reprogramming
- Gene Networks Governing Cholinergic Neuronal Identity in Vertebrate CNS
- Topical Application of Pleurotus Eryngii Extracts improves 2,4-Dinitrochlorobenzene-induced Atopic Dermatitis-like Skin Lesions in NC/Nga Mice
- Long acting Injectable Palmityl-acylated Exendin-4-loaded glycol Chitosan Hydrogels for Treating Type 2 Diabetes
- IP3 Receptors Regulate Nuclear Ca2+ and CREB Phosphorylation via CaMKII in Rat Ventricular Myocytes
- The Effect of Essential Oil on Plasma Level of 5-HT in Dementia Patients
- Antihyperglycemic and Antihyperlipidemic Effects of Fermented Rhynchosia nulubilish in Alloxan-induced Diabetic RatsRhynchosia nulubilish in Alloxan-induced Diabetic Rats
- The Protective effect of Natural Product on Age-related Macular Degeneration in APRE-19 cells
- Identification of (1-entylindol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone and Its 5-Pentyl Fluorinated Analogue
- Saucerneol D Inhibits Eicosanoid Generation and Degranulation Through Suppression of Syk Kinase in Mast Cells
- Roles of Integrin α3β1 in the Regulation of Non-small Cell Lung Cancer Cell Proliferation and Motility
- Effects of Environmental Enrichment in EEG Waves and Behavior of the ADHD Rat Model: Spontaneously Hypertensive Rat
- Syntaxin4 Cooperates with Cdo and Promotes Myogenic Differentiation
- Leptin is Induced by HER2 in Human Breast Epithelial Cells
- Combination Treatment of HDAC6-selective Inhibitors Sensitizes Colon Cancer Cells to Anticancer Agents
- Purification and Biochemical Characterization of Novel Alkaline Chitinase from StreptomycesStrain
- Enhancement of Oxidative Stress-induced Poly(ADP-ribose)ylation in the Presence of NR1D1
- A Novel Salt Dependent Alkaline Xylanase from Streptomyces sp.CSWu-1
- p53 gain-of-function Mutation Regulates Adhesion of Ovarian Cancer Cells
- Equol Enhances TRAIL-induced Apoptosis in MDA-MB-231 Cells via Caspasedependent Mechanism
- Pharmacogenomics and Pharmacogenetics of 5- Fluorouracil Koreans
- Combined Repeated Dose Toxicity Study with the Reproduction/developmental Toxicity Screening Test of Silver Nanoparticles
- Evaluation of Blueberry (Vaccinium spp.) as an Antioxidant and Epigenetic Modulator
- Intra- and Inter-variation of Urinary Creatinine in a Sex, Age, and Race Matched Group
- The Effect of Onion Extract on Platelet Aggregation, Cell Death and Inflammation According to Storage Periods and Condition
- Induction of Insulin Resistance by 11beta-HSD Catalyzed Glucocorticoid in C2C12 Myotubes
- Effect of Bis-sulfonamide Derivative MD-2-60 Suppresses NF-kB-regulated Expression of Inflammatory by Inhibiting IKKb Activity
- Development of a Novel Screening System for Anti-diabetic Compounds and its Application to the Discovery of Enolase Inhibitors
- An Extracellular Acidic Xylanase from Streptomyces sp. CS624: Economic Production, Purification and Characterization
- Rapid and Sensitive Sterility Test for Biopharmaceuticals
- The Effects of Artemisinin and Its Derivative on Immune System
- Identification and Characterization of Bacillus sp. P379DProducing Antimicrobial Peptide
- Synthesis and Biological Evaluation of Novel Resorcinol Containing Hsp90 Inhibitors
- In vitro and In vivo Activities of New Oxazolidinone, LCB01-0648 against Staphylococci
- In Vitro and in Vivo Antibacterial Activities of IDP-73152 as a Novel Peptide Deformylase Inhibitor
- Efficient Synthetic Strategy for Indolizines with Novel Substitution Patterns from 2-Acetylpyrroles
- Design, Synthesis and Biological Evaluation of 3-Heteroarylisoquinolinamines as Topoisomerase I Inhibitors
- Efficient Synthesis of Diverse 3-Acylated Indolizines Using a Sequential Sonogashira Cross-Coupling/Iodocyclization Process
- Novel Austalides Derivatives From The Marine-Derived Fungus Penicillium Thomii
- Reliable Prediction of Selectivity and Activity of ALK5 Inhibitors by Ensemble Docking and Statistical Analysis
- Cyclic Bis-1,3-dialkylpyridiniums from The Sponge Haliclona sp.
- Discovery of Potent and Selective Rhodanine Moiety IKKβ Inhibitors by Hit-to-Lead Strategy
- Effect of Foreign-originated Plants on Antiproliferation and Inhibition of Wnt/β-catenin Signaling in Human Colon Cancer Cells
- Efficient Synthetic Method of Alkylthioallylselenopyridazine Derivatives
- 3D-QSAR Study of 1,2-Diaryl-1H-benzimidazole Derivatives, New JNK3 Inhibitors for Follow-up Research to Promote Physicochemical Property and Activity
- Substance Selectivity of Porcine Pancreatic Lipase (PPL)-Catalyzed Hydrolysis Reaction
- Korean Red Ginseng Tonic Extends Lifespan in D. melanogaster
- Brominated Aromatic Furanones and Related Esters from the Ascidian Synoicum sp.
- Antiinflammatory Effects on Acute Reflux Esophagitis by Curculiginis Rhizoma Aquous Extract
- Synthesis and Biological Evaluation of Chromone Analogs as IL-5 Antagonists
- Novel IL-5 Inhibitors Based on Hydroxyethylaminomethyl-4H-chromen-4-one Scaffold
- Discovery of Bicyclic Agonists of G-Proton Coupled Receptor GPR119 for the Treatment of Type 2 Diabetes
- Tolerogenic Effects of Interferon-Gamma with Induction of Allergen-Specific Interleukin-10-Producing Regulatory B Cell (Br1) Changes in Non-IgE-Mediated Food Allergy
- S22 Induces Immunostimulatory Effects in Peritoneal Macrophage
- The Role of Ikaros in Adipocyte Differentiation
- Preliminary SAR Studies of a Novel 7-Aminopyrazolo[1,5-a]pyrimidine (7-APP) Analog as a Hepatitis C Virus Inhibitor
- Identification of HLA-DR4-restricted Immunogenic Peptide Derived from Xenogenic Porcine Major Histocompatibility Complex Class I Molecule
- Two Novel Terpenoids From An Unidentified Marine-Derived Fungus
- Synthesis and Antifungal Activity of Methyl 4,11-dioxo-4,11-dihydropyrido[1,2-a]thieno[2,3-f]indole-2-carboxylates
- Synthesis and Antifungal Activity of 1H-Benzofuro[6,7-d]imidazol-4-ols
- Synthesis of m-Carboranyl Isothiocyanate
- The Pharmacophore and 3D-QSAR CoMFA/CoMSIA Studies for FAF1 Inhibitors
- Synthesis and Antifungal Evaluation of 7-Arylpyrrolo[3,2-f]indazole-4,8(1H,7H)-diones
- Identification of Polo-Like Kinase 1 inhibitors for Cancer Therapeutics.
- Asymmetric Formal Synthesis of Schulzeines A and C
- Palladium-Catalyzed Domino Process for the Synthesis of Highly Substituted Indolizinones
- 1,2-Diaryl-1H-benzimidazole Derivatives: New c-Jun N-termainal Kinases (JNKs) Inhibitors Targeting for Neurological Disorders
- Colon Targeted Celecoxib Ameliorates TNBS-induced Rat Colitis: Pharmacological and Toxicological Aspects.
- Effects of Side-Chain Length on Ring-Closing Metathesis to Form an All-Hydrocarbon Staple in α-Helical Peptides
- Isocumarins and Phthalide Metabolites from The Marine-derived Fungus Chrysosporium articulatum
- Oral Administration of Colon-targeted Cell-permeable NFκB inhibitory Peptide Alleviates Colonic Inflammation of Rats.
- Analysis of Bioconversion Components in Jaeumganghwa-tang with Lactobacillus fermentum 145 and Lactobacillus acidophilus 162
- Discovery of Heat Shock Protein 90 (Hsp90) Inhibitors against Cancerous Diseases
- Identification of Novel 5-(Cyclohexylmethoxy)-3-(3-oxo-3-phenylprop-1-enyl)-4Hchromen-4-one Derivatives as IL-5 (Interleukin-5) Inhibitors
- Phenolic Compounds from the Leaves and Stems of Desmodium Caudatum
- Synthesis of Selenoflavone : Potential Antioxidant and Neuroprotective Agents
- Simultaneous Analysis of Toluene and O-cresol in Urine by Headspace GC/FID.
- Redistribution of Paraquat in Heart Blood, Peripheral Blood and Gastric Contents in 8 Fatalities (2010-2011)
- Determination of Evodiamine Enantiomers and Rutaecarpine in Evodiae Fructus by Chiral High-Performance Liquid Chromatography
- Proposal of Standards and Criteria for Drug Packages and Containers in South Korea
- Enantiomeric Composition Analysis of Pranoprofen in Equine Plasma and Urine by Chiral Liquid Chromatography-Tandem Mass Spectrometry
- Estimation of UV-induced DNA Damages to Suppress Expression of Protein Using Reporter Gene Assay-Based Single Cell Cotransfection Imaging Cytometry
- Quantum Dot-based Highly Sensitive Quantification of Forensic Genomic DNA Without Polymerase Chain Reaction
- Identification and Quantitation of Ginsenoside Re and Its Metabolites in Rat Urine and Feces
- Chromatographic and Electrophoretic Characterization of Partially PEGylated Polyamidoamine Dendrimers
- Chiral Self-Recognition of 3,5-Dinitrobenzoylleucine Derivatives using Pirkle-type Chiral Stationary Phases
- Study on the Difference of 18 Platycosides in Balloon Flower Roots (Platycodi Radix) in Korea Depending on Harvesting Regions by HPLC-ELSD Analysis.
- Effect of Lipid on Physicochemical Properties of Paclitaxel Loaded-solid Lipid Nanoparticle
- New Simultaneous Analytical Method for Quality Control of a New Herbal Prescription, K003 by HPLC.
- Docetaxel and Paclitaxel/α- or γ- or Hydroxypropyl-β-cyclodextrin Host-guest System : Characterization, Phase-solubility
- Synthesis and Bactericidal Activity of Ploydiguanide Silver Complexes as New-Generation Antibacterial Agents in Wound Care Applications
- Establishement of Content Criteria of Marker Compounds by Monitoring Citrus Unshiu Peel in Korea and China.
- Selective Derivatization of Catecholamines for Profiling Analysis of Biological Samples by High-temperature GC-MS Method
- Extraction Efficiency of Bioactive Compounds from Eucommiae Cortex Depending on Mineral Contents in Decoction Water.
- Choline Kinase Targeted siRNA in PEGylated Liposome for Breast Cancer Therapy in vivo
- Enhancement of Anticoagulant Activity with Heparin-reduced Gold Nanoparticles
- Involvement of GPR109A in 4-Hydroxynonenal-Induced Toxicity in ARPE-19 Human Adult Retinal Pigment Epithelial Cells
- Development and Validation of a HPLC-UV Method for the Determination of Nicarbazin Residue in Chicken Muscle
- Anti-fungal Effects of 1-methyl-1,4-dihydro-tetrazole-5-thione via Inhibition of Ergosterol in Candida albican
- The Development of Clinical Trial Results Database of Peripheral Nervous System, Antihistamine, and Antiviral Agents
- Reasons for Non-Adherence in Diabetic Patients: Quantitative and Qualitative Approaches
- Elevation of Cysteine Consumption in Tamoxifen-resistant MCF-7 Cells
- Quality Control of Alismatis Rhizoma Using Simultaneous Determination of Bioactive Compounds Together with Similarity Analysis
- Antitumor Activity of Magnolol in Colorectal Cancer Cells via Suppression of Wnt/β-catenin Signaling.
- The Future of Pharmaceutical care in Korea :from Foreign Countries' Issue and Experience
- Anti-inflammatory Effect of Wheat Bran
- Effects of δ-Catenin Interaction with LEF-1 on Wnt Signaling
- Docosahexaenoic Acid Induces M2 Macrophage Polarization through Peroxisome Proliferator-activated Receptor γ Activation
- Platycodon grandiflorum Including Playtycodin D Inhibits of IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells.
- Effects of Novel Benzofuran-2-carboxamide Derivatives on the Excitotoxic Neuronal Damage in Primary Cultured Rat Cortical Cells
- A Novel Multi-Tyrosine Kinase Inhibitor with Antitumor Activity against Stomach Cancer and Non-Small Cell Lung Cancer (NSCLS)
- Evaluation for Protective Effects of β-Ionone against Gastric Lesions
- New Anti-Inflammatory Compounds Isolated from a Marine-Derived Bacterium Pseudomonas sp.
- Anti-tumor Activity of SB365, Pulsatilla Saponin D Targeting c-Met of Gastric Cancer
- HIF-1 Inhibition by an Oltipraz Metabolite, 7-Methyl-6,8-bis(methylthio)pyrrolo[1,2-a]pyrazine
- Ameliorative Effect of Novel Vitamin Formula with Herbal Extract on Scopolamine Induced Alzheimer’s Disease
- The Antimicrobial Activity Mechanism of Sophoraflavanone B against Methicillin-Resistant Staphylococcus aureus
- Development of the Bio-absorption Enhencer from the Ginseng Saponin
- The Memory Ameliorating Effects of KHUR-34 and Its Compound KHUR-34-1 on Scopolamine-induced Cognitive Impairments in Mice
- Comparative Study of Self-microemulsifying and Self-nanoemulsifying Drug Delivery System(SMEDDS & SNEDDS) of Isradipine and Ketoconazole
- Activation of Protease-activated Receptor 2 through Gastric Refluxants Stimulates Proliferation and Interleukin (IL)-6, IL-8 and Matrix Metallopeptidase (MMP)-9 of Rat Esophagus
- Effects of a 1-Piperonylpiperazine Analog on the Metabolism of Amyloid Precursor Protein
- Ethics in Clinical Research
- Eugenol Attenuates Gluconeogenesis Induction and Glucose Production in Primary Hepatocytes and HepG2 Cells
- Regulation of Collapsin Response Mediator Protein-2 Expression via mTORdependent Pathway
- Lack of CCR5 Modifies Glial Phenotypes and Population of the Nigral Dopaminergic Neurons, but not MPTP-induced Dopaminergic Neurodegeneration
- Betulinic Acid Attenuates Lipid Accumulation through the CAMKK/AMPK/p70SK Pathways in Human Hepatoma HepG2 Cells and High Fat Diet-fed Mice.
- Reduced Autophagy Aggravates Hepatocellular Damage in Alcoholic Fatty Liver
- Temporal Profiling of Immune-Related Cytokines after Intravenous Administration of Mesenchymal Stem Cell Therapy in Cerebral Ischemia in Mice
- Preclinical Activity for the Schedule-dependent Synergism of MEK Inhibitor with 5-Fluorouracil in Human Colorectal Cancer Models
- Post-treatment with 3-Hydroxymorphinan Attenuates Motor Deficit and Dopaminergic Toxicity Induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine
- Echinacea Purpurea Root Extract Enhances Adipocyte Differentiation in 3T3-L1 Cells
- Inhibition of Excitotoxic and Aβ(25-35)-induced Neuronal Damage by Fractions Prepared from Mangosteen Pericarp in Primary Cultured Rat Cortical Cells
- Coniferyl Aldehyde Induces Heat Shock Transcription Factor1 and Resistance of Cellular Stress in Normal Cells
- Anti-Uterotrophic Effect of Extract of Larrea nitida via Anti-Estrogenic Activity
- Heterozygous Mutation of Tyrosine Hydroxylase Potentiates Dopaminergic Toxicity and Oxidative Stress Induced by Methamphetamine
- SMB-2 Protects against 6-Hydoxydopamine (6-OHDA) Induced Cell Death by Increasing Heme Oxygenase-1 (HO-1) Protein Expression through Nuclear Translocation of the NF-E2-related factor-2 (Nrf2) Protein in SH-SY5Y cells.
- Resveratrol Supplementation has Anti-skin Aging Effects in Obesity Induced by High Fat Diet in C57BL/6J Mice
- K-889 Inhibits IL-4-induced Signal Transducer and Activator of Transcription (Stat) 6 Activation by Targeting Janus kinases in Mast Cell-like RBL-2H3 cells
- Cannabinoid Receptor Type 1 Receptor Modulates Drug Addiction-related Molecules in PC12 Cells
- CYP450 Inhibition and Metabolic Reaction Phenotyping of 6′-Omethlyhonokiol, a Natural Product Isolated from Magnolia officinalis
- The Expression of Vaccinia-Related Kinase 1 Induced by Activation of Protein Kinase C δ Regulates the Neuronal Apoptosis in Cerebral Ischemia.
- The Effects of Sildenafil and Its Derivatives on Aromatase Activity in Human H295R Adrenocortical Carcinoma Cells
- SB365, Pulsatilla Saponin D Inhibits the Growth of Pancreatic Cancer through Induction of Apoptosis and Inhibition of Angiogenesis
- Global Metabolomic Analysis for Finding Biomarker Candidates from Acute Myocardial Infarction Disease
- Protective Effect of Alnus japonica Extract on a Model of Nonalcoholic Steatosis
- Anti-genotoxic Effects of Ethyl Acetate Fraction from Agrimonia pilosa Ledeb in LPS-stimulated RAW 264.7 Cells
- Ectopic Expression of Ki-67 in HT-29 Cancer Cells Grown in Multicellular Layers
- COX-2 Up-regulation in the Lung Cancer Promotes over of Multidrug Resistance Protein 4 (MRP4) via PGE2-dependent Pathway
- Discovery of p53-Hdm2 Interaction Inhibitors
- Endothelial Nitric Oxide Synthase Phosphorylation is Required for Vasodilation Effect of Amurensin G
- Generation of 3-Dimensional Pancreatic Cancer Spheroid Model Using High Throughput System
- Oxytetracycline Exposure Induces Behavioral Changes in Zebrafish
- The Role of Interleukin-17A and Leptin in the Lineage Commitment of Human Mesenchymal Stem Cell Differentiation
- Hypoxia-induced Estrogen Receptor Alpha Activation by Phosphorylation Pathways
- A Drosophila Nephrolithiasis Model for Studying Urinary Stone Formation
- Anti-Cancer Activity of HS-345, a New Tropomyosin Related Kinase A Inhibitor in Human Pancreatic Cancer
- Hepatoprotective Mechanisms of Trans-Anethole against Ischemia/Reperfusion Injury in Mice
- The Heartwood of Santalum album. Lin. Improves Learning and Memory Impairments Induced by Scopolamine via Inhibition of Cholinergic Dysfunction in Mice
- Modulations of Tyrosine Hydroxylase and Dopamine Transporter mRNA Expressions and CREB Phosphorylation by Endocannabinoids in PC12 Cell Line
- Protective Effect of GLB-12 against 6-Hydroxydopamine (6-OHDA) Induced Cell Death by Enhancing Impaired Proteasome Activity in SH-SY5Y Neuroblastoma Cells.
- Anti-inflammatory Activities of Sesquiterpene Lactones Isolated from Ixeris dentata
- Constituents of Eucommiae Cortex as Heat Shock Factor 1 Inducers
- Inhibitory Effect of Novel ALK5 Inhibitor on UUO-induced Renal Fibrosis
- Pentoxifylline Enhances the Distribution and Efficacy of Doxorubicin and Gemcitabine by Reducing Connective Tissue Growth Factor-Mediated Fibrosis in Pancreatic Tumor Xenografts
- Screening of Suppressive Effect on Th2-associated Cytokines Expression in Folk Medicinal Used Plants
- Dependence Liability of Phentermine is Involved in PI3K-AKT Pathway in the Nucleus Accumbens.
- Saxifragifolin A Induces Differential Apoptotic Effects in Human Breast Saxifragifolin A Induces Differential Apoptotic Effects in Human Breast
- Increase of Cytokines and Adhesion Molecules Production in the NRF2 Knockdown U937 Cell
- Characterization of Paclitaxel-resistant Human Lung Cancer cells
- Potential Mechanism Underlying 5-Fluorouracil (5-FU) Resistance in Human Colon Cancer Cells
- 12-O-Tetradecanoylphorbol-13-acetate (TPA) Induces Invasion of HT29 Cells by NADPH oxidase-dependent ROS Generation
- Controlled Release of bFGF Gene to hADSC for Scaffold-supported Tissue Regeneration
- Novel Intrinsic Defense Against Enteric Bacteria
- 4-O-methylhonokiol Improves Kainate-Induced Blood-Brain Barrier Disruption in Mice
- Anti-cancer Effect of Bee Venom in Lung Cancer Cells Through Activation of Death Receptors Pathway Mediated Apoptosis via Inactivation of NF-κB
- Essential Roles of Pharmaceutical Analysis in New Drug Development
- Preparation of PEGylated Exendin 4-loaded PLGA Microspheres for Enhanced Stability and Anti-diabetic activity
- Regulation of Hepatocyte Nuclear Factor 4α by a Novel Naphtofuran Derivative Compound in Liver Cancer Cell
- IL-32γ Inhibits Acetaminophen-induced Acute Hepatic Failure via Inhibition of Pro-inflammatory Cytokines Production and Infiltration of Cytotoxic Immune Cells
- Natural Product-Based Strategy for Developing Anti-Osteoporotic Drugs
- Blockade of Myd88 Signaling Induces Antitumor Effects by Skewing the Immunosuppressive Function of Myeloid-derived Suppressor Cells
- Study of Chemical Constituents and Hepatoprotective Activity of Ganoderma lucidum
- Inhibitory Effect of the Principal Constituent from Caesalphinia sappan on Osteoclast Differentiation and its Action Mechanism
- In vitro and in vivo Suppressive Effect of TRAIL in Liver Fibrosis
- Economic Impact of Drug Price Reduction in South Korea: on Drugs for Peptic Ulcer and Gastro-Esophageal Reflux Disease
- The Differential Expression of TNF-alpha Related Apoptosis Inducing Ligand and Related Factors of TRAIL in Relation to CYP1B1
- The Effect of Prilocaine·HCl on the Physical Properties of Neuronal Membranes
- A Novel Small Molecule Exhibits Anti-fibrosis Efficacy in CCl4 -treated Mouse Model
- Effects of gut Microflora on Pharmacokinetics of Geniposide in Rats
- Stem Cell Biology for Therapeutic Development in Parkinson's Disease
- Anti-inflammatory Effects of O-methylated Flavonoid
- An Evaluation of Cholesterol-lowering Effect of Soy Protein and Isoflavones on Postmenopausal Women and Hypercholesterolemic Humans.
- Two New Peptides from a Marine-Derived Fungus, Aspergillus sp.
- Development of Ophthalmic Formulation Containing FK506 (tacrolimus) Prodrugs
- The Functional Significance of -600C/A Polymorphism of Human CYP17A1 Gene
- Role of Catalase in High Fat-Induced Liver Injury
- Characterization of Reference Standards
- Discovery of Small Molecules that Regulate Tyrosinase Expression as Skin Lightening Agents
- Synthesis and Biological Evaluation of Novel Pyrimidine Derivatives as Potent GPR119 Agonists for the Treatment of Type 2 Diabetes
- Ursane-type Triterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from Rhododendron brachycarpum G.Don
- Pharmacokinetics of Methylene Blue and Its Major Metabolite, Azure B, and Brain Penetration in Rats
- Functionality Analysis of Korean Medicine Fermented by Lactobacillus spp.
- Sustained Release of Pegylated TNF-related Apoptosis Inducing Ligand Encapsulated Poly(lactic-co-glycolic acid) Microspheres for Treating Pancreatic Cancer
- Discovery of Phenylaminopyridine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors
- Mitochondrial Protection by Carnosine Contributes to the Attenuation of Brain Damage during Ischemic Stroke
- Bioequivalence Study of Ramosetron Hydrochloride Solid Preparations
- Antithrombin Constituents from the Semen of Sorghum bicolor L.
- Metabolomic Analysis of Urinary Amino Acids from Bladder Cancer Patients by Gas Chromatography-Mass Spectrometry
- 천연물로부터 면역조절물질(Immunomodulators) 연구
- Discovery of Novel P2X7 Receptor Antagonists for Pain and Inflammatory Diseases
- Anti-adipogenic Effect of a Dietary Flavonoid Fisetin in 3T3-L1 Cells
- Anti-Inflammation of Glucagon Like Peptide-1 Receptor Agonist, Exendin-4, in Stroke through Stimulating IB1/JIP1 Expressions and Modulating JNK Signaling
- Evaluation of Differences for Antihypertensive Drug Response by Sasang Constitution
- Successful Cooperation between Industry and Academia on Oncology Drug R&D
- New Biomarker-Driven Trends in Anti-Cancer Drug Development
- Prescription Drug Expenditures of Hyerlipidemia in Korea National Health Insurance
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