학술논문
Novel and highly selective small molecule kinase inhibitors for EGFR-T790M
이용수 3
- 영문명
- 발행기관
- 대한약학회
- 저자명
- SONG Jiho KIM Young-Jin LEE Seul KIM Jong-Min KIM Do-Ran CHOI Sae-Beom MIN Kyung-Hoon
- 간행물 정보
- 『춘계총회 및 학술대회』(2012년), 338~338쪽, 전체 1쪽
- 주제분류
- 의약학 > 내과학
- 파일형태
- 발행일자
- 2012.04.21
무료
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해당간행물 수록 논문
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- RV-1 from Rhus Verniciflua protects pancreatic beta cells against high glucose and palmitate-induced glucolipotoxicity through its antiapoptotic action and activating IRS2 signaling
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- Total Synthesis of (α)-(-)-Conhydrine: we are regioselective and diastereoselective amination using chlorosulfonyl isocyanate
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- Prediction of tyrosinase inhibitory activities from HPLC chromatograms of Morus alba root bark extracts
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- Inhibitory effects of JUL05 on 3T3-L1 adiopocyte differentiation and obesity induced by high fat diet in mice.
- Adenosine receptor ligands from the tropical marine sponge
- HlyD shares a binding motif to Tol with the membrane fusion proteins in bacterial tripertite drug efflux pumps
- Two new dammarane-type glycosides of Gynostemma pentapyllum
- Role of hypoxia-inducible factor in chronic rhinosinusitis
- Inhibition of HIV-1 protease and RNase H of HIV-1 reverse transcriptase activities by long chain phenols from the sarcotestas of Ginkgo biloba
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- Cytotoxic diterpenoids from the leaf of Pinus densiflora
- Myagropsis myagroides extracts induces apoptosis via a caspase dependent pathway and reactive oxygen species generation in U937 and PC-3 cancer cells
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- Retrospective analysis of the results of acellular pertussis vaccine toxicity tests
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- Inhibitory effect of oyster hydrolysate on angiotensin-i converting enzyme (ACE)
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- Services of in vivo toxicity and safety assessment in drug discovery platform technology team
- Vigna angularis blocks TLR signaling pathway and inflammatory molecules expression.
- Vigna angularis inhibit IL-6 induced Stat3 activation and C-reactive protein expression
- Natural naphthoquinones, EA272-01 and EA272-02, prevent oligomerization of Aβ and oxidative stress-induced cytotoxicity in murine hippocampal HT-22 cells
- The inhibitory effect of resveratrol on LXR-mediated lipogenic gene expression.
- A study on comparing with globalization strategies of Indian & Korean pharmaceuticals
- Lead optimization of various piperazine alkyl derivatives for anticancer chemotherapy by study of molecular properties.
- Glucagon-like peptide-1 (GLP-1) secretion is induced by hexane fraction of Citrus aurantium L. through membrane depolarization.
- Chlorogenic acid suppresses NF-kappaB and AP-1 in LPS-activated primary macrophages from C57BL/6 Mice
- Phenolic compounds from the leaves of homonoia riparia and their inhibitory effects on AGEs formation and aldose reductase
- Elucidation of Zymosan phagocytosis in macrophages using a novel small molecule regulator
- Development of RP-HPLC method for quantitation of haemagglutinin in influenza vaccine
- Structure-activity relationships of 20(R/S)-ginsenosides on HSC-T6 cell proliferation.
- Expedient synthesis of chiral homoallylamines via N,O-acetal TMS ethers and its application
- Lignan, sesquilignans and dilignans, novel HIV-1 protease and cytopathic effect inhibitors purified from the rhizomes of Saururus chinensis
- Analysis of DOPA in human urine as ethoxycarbonyl/tert-butyldimethylsilyl derivatives by gas chromatography-mass spectrometry
- Protective effects of AD-lico (roasted licorice 95% ethanol extract) in water immersion stress induced gastric injury in rats.
- Anti-proliferating effect of medicinal plants extracts against KB oral carcinoma cell line
- Parkinson’s disease-associated LRRK2 mutation causes abnormal aggresome formation by impairing microtubule dynamics under proteasome dysfuction condition
- Comparison of primary and secondary metabolites on suitability to discriminate origins of Schisandra chinensis by GC-MS and LC-MS
- The inhibitory effect of seaweed extracts on mushroom tyrosinase
- Evaluation of taste masking efficacy in pharmaceutical formulation development using an electronic tongue
- Use of information component (IC) to national health insurance database for signal detection of adverse effects of clopidogrel
- Application of hot melt extrusion for the uniform distribution of low dose drug
- The proliferation of MC3T3-E1 pre-osteoblast cells on polymeric scaffolds for bone tissue engineering
- Formulation and optimization of novel Valsartan SMEDDS using statistical experimental design
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- Developmental changes in expression of calcium-activated chloride channel TMEM16A in mouse organ of Corti
- Identification of new stress-responsive protein and its biological modulation with - omics tool
- Discovery and synthesis of new JAK2 inhibitors
- Phytochemical implication on the unconventional isolation of insect juvenile hormone Ⅲ Analogues from Cananga latifolia
- Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, shows antiinflammatory effects via expression of heme oxygenase-1
- The regulation of toll-like receptor 4 expression by hypoxic stress through phosphatidylinositol 3-kinase/Akt pathway and sulforaphane in macrophages
- Application of LC-MS in drug-drug interaction
- New drug development for metabolic and inflammatory disease
- What happened and will happen in Korean medical licensing examination
- 제주 식의약품 산업 육성 전략
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- Regulatory challenges and considerations in pharmerging markets
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- TM4SF5 as a promising target for anti-liver cancer drug development
- Novel dosage form design for drug eluting stents
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- Optimization of sophoricoside as interleukin-5 antagonist looking for novel anti-asthmatic drug
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- Effects of CYP2C9*3 and *13 Alleles on the pharmacokinetics of candesartan and its metabolite
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- Effects of Platycodon Grandiflorum including platycodin D in IgE/Ag-induced type I hypersensitivity
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- Screening of Influenza A (H1N1) neuraminidase inhibitor from the novel natural products
- International comparison of medicine prices:evidence from 16 countries
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- Strategies to upgrade patient counseling in community pharmacy setting
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- Development and validation of dissolution test for prothionamide tablets in Korea Pharmaceutical Codex Monograph
- Development and validation of dissolution test for Prothionamide tablets in Korea Pharmaceutical Codex Monograph
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- The effect of lxeris dentata in human salivary gland cells by chronic exposure of high glucose.
- Anti-inflammatory effects of constituents isolated from DMs
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- Synthesis of new naphthoquinone derivatives and their apoptitic activities in vitro
- GPScreenTM, an innovative technology for genome-wide drug target identification, and its application for natural drug target discovery
- Development of a novel matrix for imaging mass spectrometry for visualization of drug and endogenous metabolite distributin
- Baicalein shows anti-inflammatory effects in human colon cancer cells and prevents colitisassociated colon cancer in mice
- In Vivo EPR detected pathologically important OH radical in lung injuries caused by diesel exhaust particles
- Procoagulant and prothrombotic effects of herbal medicine, Dipsacus asper and its active ingredient, dipsacus saponin C, on human platelets
- Effects of arsenite on LPS-induced activation of cytosolic phospholipaseA2 in RAW264.7 cells
- Evaluation on antitumor activities of oriental medicine herb in DMBA-induced breast cancer rat
- Regulation of glucose transport by ROCK1 differs from that of ROCK2 and Is controlled by actin polymerization.
- A strategy of expression optimization for WW domains in E.coli and physicochemical studies on the WW domains
- Screening of anti-obesity drug candidate KPOS0017, a new synthetic 5-HT2C receptor ligand, by acute and two weeks repeated administration to C57BL/6 mice.
- Visualization of cytotoxicity of cytokine-induced killer cells in vitro
- Induction of NCAM expression by IL-32γ leads to activation of natural killer cells.
- Modulation of NADPH oxidase and MMP-9 activities by β-glucans of Phellinus baumii and Ganoderma lucidum in macrophage
- Antibacterial and Anti-inflammatory activities of PA5 compound produced by Bacillus subtilis from Korean traditional kimchi
- Immune response of Ginsenoside Rd to Candida albicans-cell wall in BALB/c mice.
- Generation of L5K5Wn model peptide isomers possessing antimicrobial and anti-inflammatory activities
- Synthesis and bioactivity of novel adamantyl derivatives as potent MDR reversal agents
- Synthesis and biological activities of 2,3-dihydronaphtho[1,2-b]furan-2-carboxamide derivatives
- Antagonist of the RAGE as therapeutic agents of Alzheimer’s disease
- Synthesis of sulfonamide-substituted flavones and their biological activities
- Metabolic syndrome effect of the phenolic compounds isolated from Celtis biondii
- Highly enantioselective total synthesis of (+)-isonitramine
- Stereoselective total synthesis of radicamine b & (-)-codonopsinine
- Stereoselective total synthesis of conduramine E-1
- CD11b+ immunosuppressive myeloid cells are maturated during tumor progression
- AEG-1 Prevents Neuronal Cell Death after Focal Cerebral Ischemia
- Natural vnadium-containing Jeju ground water suppresses anaphylactic reaction and inhibits eicoanoids production and degranulation in IgE/Ag-induced mast cells
- Role of type 1 inositol 1,4,5-trisphosphate receptors in the regulation of spontaneous Ca2+ SPARKs in rat atrial myocytes
- Magnolin as a novel chemopreventive agent
- Aschantin suppresses EGF-induced neoplastic cell transformation
- Effects of cellular 11beta-hydroxysteroid dehydrogenase 1 on IL-1beta- or LPS-induced immune responses in synovial cell line SW982
- Identification of chlorophyll a as an immune activator from environmental-friendly cultivated green pepper
- Protective action of SIRT1 against UVB-induced cell senescence: p53 deacetylation and suppression of oxidative stress
- Effect of baicalein on the sumatriptan bioavailability after oral and intravenous administration of sumatriptan in rats
- Effects of Atractylodes japonica on the metabolism and pharmacokinetics of caffeine in Rats
- Regulation of the AMPK activity by peptidyl-prolyl isomerase Pin1 in hepatocarcinoma cells
- Dieckol, isolated from marine brown algae Ecklonia cava, induces ROS-mediated apoptosis in human ovarian cancer cells.
- Jaceosidin causes inactivating phosphorylation of Cdc25C-cdc2 via ATM-Chk1/2 activation leading to G2/M cell cycle arrest in human endometrial cancer cells
- Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARSassociated coronavirus (SCV) and hepatitis C virus (HCV).
- A new statistical method to navigate well-matched combination of medicinal herbs for diabetes mellitus in traditonal east Asian medicine.
- In silico docking studies of carborane-containing CXCR4 ligands
- Synthesis and biological properties of Benzo-Annulated 4(3H)-Quinazolinone Alkaloids, Rutaecarpine, Tryptanthin, and Luotonin A
- A scientific basis collection on the efficacy of medicinal plants in Pyeongchang areas
- A new saponin and other constituents from Anemone rivularis Buch.-Ham.
- Preparative separation of major flavonoids in Opuntia ficus-indica by high-speed countercurrent chromatography
- Effect of fermented red ginseng on memory impairment and β-amyloid reduction in Alzheimer’s disease experimental models
- Discrimination of Angelica gigas according to geographical origin using nearinfrared spectroscopy
- Constituents with DNA Topoisomerase I and II Inhibitory activity and cytotoxicities from Euonymus alatus (V)
- Simultaneous determination of four compounds in Rhus verniciflua strokes using HPLC-PDA
- Antitumor activity of a novel (-)-antofine analog in A549 human lung cancer cells
- Chemical constituents from Viscum album and their inhibitory activity against β-amyloid production
- Syntheses of sulfur analogues and selenium analogues of pachastrissamine via cyclic sulfate
- Design, synthesis, and in vitro cytotoxicity evaluation of 3,4-diarylpyrazole derivatives
- Effect of Angelica archangelica L. (AaL) on the protective of hyperlipidemic diet in rats
- Anti-inflammatory effect of the Cirsium japonicum var. ussuriense 70% ethanolic extract in RAW264.7 cells by heme oxygenase-1 expression
- The effects of Taraxacum platycarpum H. Dahlstedt on scopolamine-induced amnesia in mice.
- Immune modulation of the water extract from Poecilocoris lewisi and its composition of glycosaminoglycan
- Anti-inflammatory effect of the extract and glycosaminoglycan from Isaria sinclairii
- Anti-oxidative effect and HPLC analysis of extract form Smilax china and its isolated compounds
- The effects of Lilii Bulbus on smoking induced mice model of emphysema
- Anti-adipogenic chromone glycosides from Cnidium monnieri fruits
- Antioxidative activities and nitrite-scavenging abilities of wheat bran
- New macrolactins as antibiotics produced by the marine-derived bacterium Bacillus sp. 102CH635-3
- The effects of Lilium lancifolium Thunberg on smoking induced mice model of emphysema
- Four new lignans from Saururus chinensis
- Anti-inflammatory effects of Gracilaria chorda via multicellular signaling pathways in LPS-induced RAW 264.7 cells
- Preparative isolation of chemical constituents from the roots of Phlomis umbrosa by high-speed counter-current chromatography
- Inhibitory effects of Rubus coreanus on 3T3-L1 adiopocyte differentiation.
- The antioxidant components from one north China mountain herb, Ledum palustre L
- Anthocyanin analysis of Korean color potatoes using HPLC-ESI tandem MS
- The effects of lignan-enriched extract of Shisandra chinensis (ESP-806) on amyloid-β-induced behavioral dysfunction and neurotoxicity in the cortex and hippocampus of Mouse
- The change of ginsenoside composition in Red ginseng (Panax ginseng) by the microwave and vinegar process
- Preparative isolation and purification of three diarylheptanoid glycosides with antioxidant activity from Alnus japonica
- Metabolism of ginsenoside Rb1 by human intestinal microflora
- Development of quantitative assays for acepifylline tablets in KPC
- Comparison of three analytical methods for the determination of bioactive components in rhubarb
- Anti-diabetic effects of marine resources using subcritical water and solvent extraction method
- Phospholipid fatty acids as biomass indicator for biofilms
- Structural analysis of Sur2391-582, the binding core of ESX and discovery of a new ESX-binding core of Sur2, Sur2384-521
- β-Amyloid production inhibitory effect of alkaloids from Lycoris chejuensis
- Optimization of electrospray ionization condition for high sensitivity peptide mapping of a monoclonal antibody using LC/MS/MS
- Preparation, characterization and in vitro release study of liposomal apoptosis inhibitor
- In vitro drug release and skin permeation study of finasteride-loaded monoolein nanoparticles for topical delivery
- The effect of local anesthetics on the lateral mobility of model membranes
- Structural insights into the regulatory mechanism of inosito 1,4,5-trisphosphate receptor
- Physicochemical properties of HPMC-P and its application to enteric coated tablets and capsules
- Self-organized Chitosan nano-sized hydrogels containing an anti-diabetic peptide for pulmonary delivery
- Bioavailability enhancement of Carvedilol formulation by solid dispersion system
- Development of Ibuprofen-loaded solid dispersion using Cycloamylose
- Preparation and characterization of novel protein-based conjugate for anticancer agent delivery
- Establishment of assay specification in Fennel
- Preparative isolation of verproside from methanolic extract of Pseudolysimachion longifolium by high-speed counter-current chromatography
- Effects of Triticum aestivum herbal extract on the lipid levels in the serum and liver tissue of C57BL/6J mice fed high fat diet
- The metabolomics of volatile oil components between Angelicae sinensis and Angelica gigas by GC-MS
- Enantioseparation of N-methyl aspartic acid in rat brain tissue as Nethoxylcarbonylated
- Liquid chromatography quadrupole time of flight mass spectrometry analysis of neuroactive steroids in rat plasma and brain
- Quantitative analysis of sphingomyelin by high-performance liquid chromatography after enzymatic hydrolysis
- Rational development of a model for solvent gradients selection in single-step separation of ginsenosides from Panax ginseng using high-speed counter-current chromatography
- Development of quantitative assays for caroverine tablets in KPC
- Alternative visualization of SDS-PAGE separated phosphoproteins by Axx-aluminum (III) complex
- Two new secondary metabolites produced by Micromonospora echinospora isolated from the larva of dung beetle
- Metabolomics approaches based on gas chromatography-mass spectrometry for the discrimination of geographical origins of medicinal herb, Jakyak
- Buddleja officinalis Maximowicz extract inhibits lipid accumulation
- Proteomic analysis for biochemical and cellular characterizations of hexa EF-hand calcium binding protein secretagogin
- Interactome of FAF1, Fas associated factor 1, and their biological function.
- LC/MS-based multivariative analysis for the comparative metabolism study of xenobiotics
- Effect of the solid-dispersion method on the solubility and crystalline property of tacrolimus
- Difference of physicochemical properties of solid lipid nanoparticles for encapsulating docetaxel and paclitaxel
- Effect of saturated fatty acids on tacrolimus-loaded liquid crystalline nanoparticles
- Effect of the particle size of HPMC on dissolution rate of venlafaxine HCl and Carbamazepine sustained release tablet
- Preparation and characterization of Gemcitabine micro/nanoarticles for oral delivery
- In vivo Assessment of Anti-tumor Effects of Doxorubicin-loaded porous poly(lactic-co-glycolic acid) microspheres In a metastastic lung cancer model
- Preparation, characterization and optimization of Fenofibrate loaded self-microemulsifying drug delivery system (SMEDDS)
- Pharmacokinetics of Piperine and its effect on the tissue distribution of Paclitaxel, a substrate for Pglycoprotein
- Summarized report of physicochemical screening in KRICT
- The effect of Naringin on prokinetic activity
- Combination delivery of adiponectin genes and rosiglitazone using cationic lipid nanoparticles
- A stable formulation of clopidogrel bisulfate in omega-3 oil
- Summarized report of ADME/PK screening data in KRICT in years 2010-2011
- Preparation and characterization of exenatide-loaded poly(DL-lactic-co-glycolic acid) particles
- Validation of a ECLIA method for in vitro potency assay of human immunoglobulins
- Assay error for improved pharmacokinetic modeling and simulation of vancomycin
- Over-prescription or not? How long should it be?
- A study for the standardization of medical devices: tracheal tube
- Therapeutic drug monitoring(TDM) of the antituberculosis drugs in patients with diabetes mellitus(DM)
- Development and in vitro/in vivo evaluation of loxoprofen extended release tablets
- Characteriation and preparation of Solid Lipid Nanoparticles (SLNs) versus Nanostructured Lipid Carriers (NLCs) of 6-Methoxyflavone
- Preformulation and formulation of newly synthesized QNT3-18 for development of a skin whitening agent
- Development and Validation of Dissolution Test for Prothionamide Tablets in Korea Pharmaceutical Codex Monograph
- 3,5-Dicaffeoylquinic acid attenuates dimethylnitrosamine-induced?liver fibrosis in vivo
- A extended-release formulation of KOB and pseudoephedrine.
- Determination of KR-25659, a novel TAZ modulator, in rat plasma by liquid chromatography?tandem mass spectrometry
- Pharmacokinetic study of Srx Inhibitor in rats using simple HPLC method
- Prescription pattern monitoring of antihypertensive drugs in South Korea during 2009-2010 using WHO-ATC/DDD tool
- Investigation of prokinetic effect of poncirus fructus
- Development of amniotic membrane extract-loaded double layered wound dressing
- Inhibitory effect of shikonin on adipocyte differentiation through down-regulation of ERK 1/2 phosphorylation
- Enhanced Dissolution of Flubirprofen via the Preparation of Organo-Clay Based Drug Delivery System
- In vivo release kinetics from rod type implant loaded with IGF-1 and TGF-β for enhanced cartilage regeneration
- Fabrication of size-controlled PLGA nanoparticles
- The effect of caffeine and coffee on blood pressure.
- Patterns of medication adherence with lipid lowering drugs and its affecting factors
- The immunoadjuvant efficacy of a N-carboxymethyl low molecular weight water-soluble chitosan (NCMCh) for protein-based vaccines
- International comparisons on the post-graduate program specialized in pharmaceutical industry
- Establishment of dissolution specification for sulpiride capsules
- Development FcBP-protein nanocage as a novel delivery flatform
- Comparison of inhibitory effects between self-fermented pine needle fractions on catecholamine secretion from the adrenal medulla
- 4-hydroxybenzyl methyl ether ameliorates scopolamine-induced memory dysfunction in mouse
- Potentiation of vasoconstriction and pressor response by low concentration monomethylarsonous acid
- Identification of small molecules which inhibit Hepatitis C virus RNA genome replication
- Anthraquinone from Polygonum multiflorum
- Pharmacokinetics and correlation analysis of cilostazol in Korean healthy subjects
- The anti-depressant evaluation of inhalation with clary sage oil in depressive women.
- Total stero synthesis of A-82768
- [5-(3-Indol-1-ylpropoxy)-1H-indol-3-yl]acetic acid enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells
- Direct C-H cross-coupling approach to heteroaryl coumarins
- Cordycepin inhibits sRANKL-induced osteoclast differentiation
- Antifugal components from Hosta capitata
- The relaxant effects of quercetin on the smooth muscle of rabbit penile corpus cavernosum
- Structural information of disease related proteins for innovative drug discovery
- Oral liposome formulation of docetaxel
- Biological activities of bromo-retrochalcone derivatives on peroxisome proliferatoractivated receptors (PPARs)
- Effect of oral administration of Phellinus baumii β-glucan on rat serum composition
- 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety and evaluation for antitumor activity
- Antibacterial activity of aurcumin against methicillin-resistant staphylococcus aureus
- Effects of catalpol-related iridoid glucosides, verproside, picroside II, and isovanilloylcatalpol on cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes
- Priming of Wharton’s jelly-derived mesenchymal stromal cells with ROCK inhibitor improves functional recovery of mice with intracerebral hemorrhage stroke
- Antioxidative and hepatoprotective effects of the ethanolic extracts prepared from the seeds of Opuntia ficus-indica var. saboten
- LS-1 induces the apoptosis of SNU-C5 colorectal adenocarcinoma cells by the activation of TGF-β Signaling
- Effect of diltiazem, a moderate CYP3A4 inhibitor, on the pharmacokinetics of tamsulosin
- Postgraduate medical education (PGME) in S. Korea
- Discussion / Q&A
- Positive cross-talk between hypoxia inducible factor-1α and liver X receptor α induces formation of triglyceride-loaded foam cells
- Inhibition of tumor suppressor expression and function by hypoxia microenvironment
- Adverse drug reaction (ADR) signal detection research using administrative data for public insurance
- Eupatorium Chinensis var. Simplicifolium extract inhibits apoptosis through induction of intracellular HSP70 and suppression of JNK phosphorylation in C2C12 myoblasts
- Neuroprotective effects of HB08 against dopamine-induced cell death by regulating nurr1 and asynuclein expression.
- Ethanolic extract of Zizyphus jujuba var. spinosa ameliorates cognitive impairment induced by cholinergic blockade in mice
- The effect of selected phyto-compounds against degranulation in antigen-induced rat basophilic leukemia (RBL-2H3) cells
- Involvement of cellular redox state in TGFβ-mediated epithelial mesenchymal transition of KEAP1 inhibited human renal epithelial cells
- Anti-obesity and fatty liver inhibition effects of laminaria japonica areshoung ethanol extracts in high fat-fed rat.
- Induction of fas-mediated extrinsic apoptosis, p21WAF1-related G2/M cell cycle arrest and ROS generation by costunolide in estrogen receptor-negative breast cancer cells, MDA-MB-231
- Anti-inflammatory activity of austroinulin from stevia rebaudiana in LPS-induced RAW 264.7 cells
- Protective effects of ES extract on alcoholic fatty liver induced ethanol diet fed rats
- Suppression of Th2-associated cytokines expression by schizandrin in basophils and
- Mollugin reduces P-glycoprotein expression through the NF-κB pathway and AMPK activation-dependent CREB activity
- In vitro and in vivo anti-inflammatory activities of polygonum hydropiper methanol extract
- A HPLC method for the determination of U0126 in rat plasma and its application to U0126 pharmacokinetic study
- Inhibition of metastasis and angiogenesis by kahweol through suppression of STAT3 activation
- Role of intestinal microflora in baicalin metabolism in a germ-free animal model
- Effects of chlorella supplement on global and gene specific methylation: a human intervention study
- A changes on quality evaluation of sesame oil marketed in Seoul by Korea food code from 2006 to 2011
- Enhancemt of antitumor activity of combination treatment of WK4 extracts with 5-FU in colorectal cancer xenograft model
- ARD1 regulates cell motility mediated by acetylation of tubulin
- Simultaneous determination of targeted drugs in human blood by using QTrap-LC/MS/MS
- Anti-allergic activity of emodin: inhibition of eicosanoids, proinflammatory cytokines production and degranulation in IgE/Ag-induced mast cells
- Leukotriene B4 induces epithelial mesenchymal transition in cancer cells
- Apigenin sensitizes HepG2 cells to TRAIL-induced apoptosis through ERK-mediated DR5 upregulation
- The impact of diarylpropionitrile, a specific agonist of estrogen receptor beta on hypoxia inducible factor-1 inhibition by estrogen receptor beta
- Chalcones from the flowers of Coreopsis lanceolata.L
- Cbl and Src regulate Sirt2 through ubiquitination and phosphorylaion
- Thiourea derivative QNT4-32 inhibits stem cell factor-induced melanin production in B16 melanoma cells
- Yuanhuadine inhibits bacterial LPS-induced inflammatory signaling in macrophages
- The length of L2 loop is critical for caspase-7 active site conformation
- The chenodeoxycholic acid inhibit bone loss via suppression of osteoclast formation
- Protein-ligand docking of known 5-lipoxygenase inhibitors
- A stereocontrolled access to functionalized macrolactams via aza-Claisen rearrangement
- Discovery of 3,4-dihydropyrimidin-2(1H)-ones with inhibitory activity against HIV-1 replication
- Synthesis of pyrimidine-4-yl-1H-imidazole derivatives as type II Raf kinase inhibitors
- Synthesis of aurones as acetylcholinesterase inhibitors
- Ligand-based design, synthesis and biological evaluation of a novel series of RAGE (Receptor for Advanced Glycation End Products) inhibitors
- Pharmacophore model building for antitubercular activity of monocyclic nitroimidazole analogues.
- Synthesis of hydroxychalcones as potential anti-angiogenic agent
- Synthesis and biological evaluation of caffeic acid analogues for antioxidant activities
- Lipase catalyzed acetylation of secondary alcohols and amines in microflow system
- Sungsanamide, a novel lasso-peptide from a deep-sea actinomycete, streptomyces sp.SNJ013
- Novel and highly selective small molecule kinase inhibitors for EGFR-T790M
- SNW10, New Linear polyketides from the marine Actinomycete, Streptomyces sp.SNW10
- Discovery of novel small molecule regulators for tyrosinase expression as skin lightening agents
- Synthesis and DNA cleaving activity of chiral ruthenium complexes
- Cyotoxicity of petrosiacetylenes from the east sea marine sponge Petrosia sp.
- Absence of mutagenicity in Tetrapleura tetraptera, a Nigerian plant.
- The Protective mechanism of Quercus salicina Blum extract in calcium oxalate urolithiasis model
- Antioxidant constituents from Acanthopanax henryi evidenced by their free radicalscavenging capacity
- Artemisia capillaris extracts as a powerful reducing agent for the green-synthesis of silver nanoparticles
- Autophagy inducing effect of chebulagic Acid in HT22 and SH-SY5Y Cells
- Qualitative analysis of nine compounds from stem barks of Fraxinus rhynchophylla by HPLC-DAD
- Inhibitors of LPS-induced nitric oxide production in macrophage RAW264.7 cells from Sargassum Muticum
- The immunoenhancement and anticancer potential of cold water-soluble Gastrodia elata extract
- Ginsenoside Rh1 ameliorates high fat diet-induced obesity.
- The inhibitory effect of seaweed extracts on α-glucosidase.
- Synthesis of novel 5'-oxy and 5'-deoxyphosphonic acid nucleoside analogues as potent antiviral agents
- Duchung prevents triglycerol accumulation and ER stress in HepG2 cell.
- Antidepressant like effects of CJ-SU in mouse models of forced swimming test.
- Screening of G-protein-biased agonists for a high affinity niacin receptor, GPR109A
- Syk/Src pathway-targeted inhibition of skin inflammatory responses by Carnosic acid
- Detection of para-fluorinated phenethylamine-type synthetic drugs in urine
- A new fluorescent small molecule bioprobe for blood vessel in live animal
- The inhibitory effect of resveratrol on LXR-mediated lipogenic gene expression.
- pH and temperature stability of polyvinyl alcohol microspheres prepared from vinyl acetate and vinyl pivalate
- Investigation of efficacy of Val-SN-38, a valine-ester prodrug of anti-cancer agent SN-38
- Differential epigenetic regulation of calpain and its endogenous inhibitor calpastatin by? 5-Aza-2’-deoxycytidine and trichostatin A in neuronal SH-SY5Y cells
- Inhibitory effect of N-acyl dopamines on allergic response in IgE-mediated RBL-2H3 cells
- Adverse effects of allyl disulfide on the hippocampal neurogenesis
- Glucocorticoid represses hypoxia-induced COX-2 and inhibits hypoxia-inducible-factor-1a through induction of glucocorticoi-induced leucine zipper
- Epigenetic control of metastasis-associated protein 1 gene expression by hepatitis B virus X protein during hepatocarcinogenesis
- The orpHAN nuclear receptor RORα suppresses the TNFα-induced inflammatory response in the rat primary hepatocytes and kupffer cells
- Anti-hepatitis B virus activity of bifidobacterium adolescentis SPM0212
- Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by Streptomyces sp. extract through the NF-kappaB inactivation in RAW 264.7 macrophage cells.
- Study about Establish the Suitability of using ATP assay for Viable Counts of BCG Moreau vaccine
- Inhibitory activities of isoflavonoids on rat prostate testosterone 5α-reductase
- Anti-Inflammatory activity of the methanol extract of Rhodomyrtus tomentosa (Aiton) Hassk.
- Synthesis and Molecular Docking Study of 5,7-Dihydroxyflavonol-Amino acid Conjugates as a JAK3 Inhibitor.
- 2-[4-(Methylsulfonylamino)phenyl]propionamide analogues as potent TRPV1 antagonists and analgesics
- Receptor-based discovery of novel ERRγ inverse agonists: highly selective pyrazolamides
- 1-Step enantioselective synthesis of (+)-Tetrabenazine
- Design, synthesis, and biological evaluation of novel RhoB mediated pathway modulating anticancer agents
- Selective and slow-binding inhibition of shikonin derivatives isolated from Lithospermum erythrorhizon on glycosyl hydrolase 33 and 34 sialidases
- Stilbene derivatives from Rhubarb show anti-inflammatory and anti-oxidative activities by induction of heme oxygenase-1 through Nrf2 signaling pathway in LPSactivated RAW 264.7 macrophages.
- The effects of Lilium lancifolium Thunberg on smoking induced mice model of emphysema
- Isolation and identification of autophagy-inducing compound from Raphani Semen
- Quantitative analysis of 5,7-dihydroxy-6-geranyl flavanone from Robinia pseudoacacia var. umbraculifera by several extraction method
- Dioscorea batatas water extract attenuates the levels of body weight and serum lipids in mice fed high fat diet
- Cognition-enhancing activity of the standardized extract of Betula platyphylla bark by HPLC-DAD-ESI-MS, and its major diarylheptanoids in scopolamine-induced amnesic mice through CREB phosphorylation
- Development of leukemia-targeted antibody alternatives, variable lymphocyte receptors (VLRs).
- Natural vanadium-containing Jeju ground water stimulates glucose uptake through the LKB1-AMPK pathway in L6 myotubes and reduces blood glucose level and increased HDL-cholesterol level in db/db mouse
- Trend and support policy for drug development
- A novel carbazole derivative, MHY407, sensitizes doxorubicin-, etoposide-, and radiation-induced cytotoxicity of breast cancer cells via?cycle arrest and pH2AX activation
- Effects of MRP2 C-24T genetic variant on the pharmacokinetics of valsartan
- Design and synthesis of benzoxazole containing indole analogs as peroxisome proliferatoractivated receptor-γ/δ dual agonists
- High-resolution metabolomics: potential tool to identify biomarkers in early period of diseases
- Hepatic sulfur amino acid metabolism in obese and diabetic animal models
- Attention deficit/hyperactivity disorder like behaviors in mice lacking dopamine transporter
- Global trends in pharmaceutical regulations
- Quality control and phytoequivalence in herbal preparation development
- Prodynorphin gene deficiency potentiates the alterations in M1/M2 microglial differentiation induced by MPTP or MA
- Regulation of human SMAD4 gene expression in the gastric cancer cells
- Anti-inflammatory effects of Arbutin in lipopolysaccharide-stimulated BV2 microglial cells
- Synthesis and evaluation of decursin derivatives as inhibitor of the Wnt/β-catenin signaling.
- Panax ginseng and Veratrum nigrum mixture inhibits obesity in high-fat diet induced obese mice
- Fluorescent 2-styrylpyridazin-3(2H)-ones derivatives as probes targeting intracellular amyloid-beta aggregates
- Activity of 6 spp. herbal extracts on proliferation of the human osteoblast cell
- Smad ubiquitylation regulatory factor 2 promotes YY1 degradation
- Effects of OCT2 602C>T genetic variant on the pharmacokinetics of lamivudine in koreans
- Effects of Anthriscus sylvestris ethanol extract on human dermal fibroblasts.
- Metabolic Syndrome Effect of the Phenolic Compounds Isolated from Celtis biondii
- Studies on acute hepatotoxicity of two crude drugs - Foeniculum vulgare and Pleuropterus multiflorus
- Nrf2 Competes with FXR for Acetylase Binding, Which Results in Inhibition of Hepatic Lipid Accumulation
- New drug development of periodontal disease from natural product
- 제주 바이오 산업의 특성화를 위한 관련제도 검토
- R&D status and medium-term plan for pharmaceutical standardization & quality review
- APEC harmonization center: progress to date and future prospects
- A novel botanical drug, Motilitone and its application in China
- Introduction of KDDF (Korea drug development fund)
- Strategic approaches to treating orphan diseases: spinal muscular atrophy, a case in point
- Hepatoprotective effects of thiacremonone, a sulfur compound isolated from garlic, on the acetaminophen-induced hepatotoxicity
- The regulation of alpha-synuclein on tyrosine hydroxylase or dopamine beta hydroxylase
- Ginsenoside Re prevents methamphetamine-induced dopaminergic toxicity in vivo and in vitro:attenuation of protein kinase Cδ activation, apoptosis and mitochondrial dysfunction.
- The pivotal mechanism for antiplatelet effect of Chrysophanol-8-O-glucoside
- Transcriptional activation of RAR by isoflavonoids obtained from Glycine max and Rhynchosia Nulubilis extracts
- Selective inhibition of matrix metalloproteinase-9 gene expression by Mangiferin, a glucosylxanthone isolated from Anemarrhena asphodeloides, in human astroglioma cells
- Inhibitory effects of Geranium thunbergii compounds on rat lens aldose reductase
- Preparatine isolation of alodose reductase inbitors from Abeliophyllum distuchum by high-speed counter current chromatography
- Functional analysis of AKAP12 in Zebrafish heart development
- Triticum aestivum dichloromethane fraction inhibits lipid accumulation in 3T3-L1 preadipocytes
- Inhibition of the Wnt/β-catenin pathway by hydnocarpin, a biphenylpropanoid isolated from Lonicera japonica, in human colon cancer cells
- Purification and crystallographic study of arabidopsis Scp1-like small phosphatase 4
- Correlation study of nano-sized micellar carriers and amphiphic block copolymers forming micelles
- Psammaplin A induces autophagy cell death via SIRT1 in doxorubicin-resistant human breast cancer MCF-7/Adr cells
- Defense of infectious disease by novel imune-stimulator
- Polo-like kinase 1: A promising target for pharmaceutical treatment in cancer
- Structure and function of oxysterol binding proteins in cellular lipid homeostasis
- Symptomatic relief and disease modifying effects of SKL-PD: preclinical and clinical evidence
- Implementation and outcomes of an innovative collaborative teaching-service model of pharmaceutical-care
- Pharmacokinetics and first-pass elimination of metoprolol in rats: contribution of intestinal first-pass extraction to low bioavailability of metoprolol
- Artesunate activates Nrf2 pathway-driven anti-inflammatory potential through ERK signaling in microglial BV2 cells.
- Determining neurotransmitters of mouse brain Sections following exposure to 835 MHz radiofrequency by using liquid chromatography coupled electrospray tandem mass spectrometry.
- Direction of strenthening the investment value of healthcare industry from the perspective of investors
- Globalization of domestic research and development of new medicines
- Identification of targets for cancer therapy in mitosis
- High-throughput combinatorial synthetic technology in drug discovery
- Anti-cancer activity of (E)-2, 4-bis (p-hydroxyphenyl)-2-butenal through inactivation of NF-κB and regulation of death receptor in human non small cell lung cancer cell lines.
- Diynes analogues as a novel cancer chemopreventive agents
- Effects of Platycarya strobilacea MeOH extract on the metabolism of amyloid precursor protein
- Regulatory role of interleukin-6 against trimethyltin-induced neurodegeneration: implication of astrocytic cells for synthesis of interlukin-6
- Murrayafoline a induce G0 /G1-phase arrest in platelet-derived growth factor-BB-stimulated vascular smooth muscle cells
- Semi-synthesized diosgenin-like saponins inhibit cell growth through estrogen receptor signaling pathway and induce apoptosis in MCF-7 breast adenocarcinoma
- Evaluation of neuroprotective and antioxidant effects of α- and γ-Mangostin in the primary cultured rat cortical cells
- Requirement of protein L-isoaspartyl O-methyltransferase for transcriptional activation of Trefoil Factor 1 (TFF1) gene by estrogen receptor alpha
- Identification of novel lipid regulator using Zebrafish in vivo fluorescent lipid labeling
- Effect of triglyceride chain length on the stability of total nutrient admixtures
- Competitiveness in exports of pharmaceuticals to developed countries: a policy comparative analysis on South Korea and India
- Therapeutic Drug Monitoring(TDM) of the Antituberculosis Drugs in Patients with Diabetes Mellitus(DM)
- Establishment of plasma lipidomic platform using UPLC-QTOF
- Chiral purity test of valsartan preparations by capillary electrophoresis with acetyl-β-cyclodextrin as a chiral selector
- Synthesis, biological evaluation and characterization of mechanism of action of human topoisomerase type II alpha specific inhibitors
- Determination of geniposide in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study
- Novel post-translational modifications in cellular peroxiredoxin 6 by proteomic analysis
- Fabrication of a uniformly sized Fenofibrate microemulsion by membrane emulsification
- Validation of human liver microsomes (HLM) model to evaluate CYP inhibition potential of new drug candidates.
- Determination of PDE-310, a novel Phosphodiesterase-4 inhibitor, in rat plama by liquid chromatography - tandem mass spectrometry
- Development of a rapid and sensitive LC-MS/MS method for the determination of homosalate in rat plasma
- Cytotoxicity effect of lapatinib derivatives on cancer cell possibly through an amino acid transporter
- Systemic analysis of ROS-regulated proteome in breast cancer cells using proteomic analysis
- Phenolic compounds from aerial bulbils of Dioscorea batatas
- Lupenone isolated from Sorbus commixta Hedlund that inhibits osteoclastogenesis by modulating RANKL signaling pathway
- Effect of shape of microneedle on the release profile of ibuprofen
- Food, supplements-drug interaction on nine cytochrome P450 enzyme activities with astaxanthin, β-cryptoxanthin canthaxanthin, lutein and zeaxanthin
- Amelioration of fatty liver with alcohol extract from Allomyrina dichotoma and its composition of glycosaminoglycan
- Region-specific changes of CAMKⅡ in cannabinoid receptor type 1 knockout mice
- Phenolic constituents of Parthenocissus tricuspidata and their effects on pancreatic lipase and adipocyte differentiation.
- Cordycepin increases non-rapid eye movement (NREM) sleep via adenosine A1 and A2A receptors in rats
- The ameliorating effect of oriental medicines on scopolamine induced memory impairment in mice.
- Evaluation of time-dependent inactivation of Human Cytochrome P450 3A4/5 by Cilostazol and its two metabolites, OPC-13015, OPC-13213, and prediction of in vivo drug-drug interaction
- Rh-catalyzed sp2 C-H bond functionalization: direct synthesis of 3-hydroxyisoindolin-1-ones
- Stereoselective synthesis of α-Conhydrine
- Distinctive roles of RIP1 and RIP3 in caspase-independent cell death of L929
- Inhibitory effect on nitric oxide production and antioxidative activity of the culture broth extract of Aspergillus parasiticus
- Effect of decursinol angelate on the pharmacokinetics of theophylline and Its metabolites in rats
- Determination of zafirlukast in human plasma using a LC-MS/MS analytical method and its application to a pharmacokinetic study
- Detection of hydroxyl radical reduction activity of red ginseng extract using ESR spectroscopy
- New herbal drug, Shinabro for osteoarthritis
- 3’,4’,7-Trihydroxyflavone inhibits activation of NF-κB translocation via phosphorylation of MAPKs and PI3K/Akt pathway to SH-SY5Y cells from hydrogen peroxide-induced neuronal cell death
- Maturation of dendritic cells by glucan isolated from Umbilicaria Esculenta
- Development and evaluation of SPG membrane emulsification system for enhanced oral bioavailability of Itraconazole
- Current status of early phase clinical trial in Korea.
- Barriers impeding the local pharmaceutical industry’s exportation to developed countries
- Development and evaluation of ophthalmic in situ hydrogel containing a cyclosporine A nanoemulsion
- Discovery of antimalarials using chemical genomics
- Effect of lycopene on high fat diet-induced fatty liver and involvement of microRNA-21 mediated repression of FABP7
- Design and synthesis of novel cyclopentane-linked alkylphosphocholines as Akt phosphorylation inhibitors
- Comparison of the effect and brain uptake of phenylbutyrate in normal rats and Parkinson’s disease model rats
- Reaching for the deep proteome
- Omics-approaches to clarify environmental causes of endocrine related cancer
- Post-translatomics in proteomic study
- KM110329 inhibits the production of pro-inflammatory cytokines through inhibition of the NF kB signal pathway in human mast cell line (HMC-1)
- Patent dispute and preparation for Korea-US FTA
- Anti-inflammatory effects of 8,8’-bieckol, isolated from Ecklonia cava, suppression of LPS-induced nitric oxide and PGE2 production and inflammatory cytokine expression in macrophages via NFkB inactivation.inactivation.inactivation.
- Is the differential copayment scheme regarding to diseases helpful and reasonable to reduce patients’ financial burden of prescription drug cost effectively and equally?
- Anti-proliferative effect of (19Z)-halichondramide with the G2/M cell-cycle arrest and inhibition of mTOR pathway in human lung cancer cells
- Chiral purity test of valsartan preparations by capillary electrophoresis with acetyl-β-cyclodextrin as a chiral selector
- Chemical constituents of Cynanchum wilfordii and the chemotaxonomy of two species of the family Asclepiadacease, C. wilfordii and C. auriculatum
- Anti-inflammatory, anti-nociceptive, and anti-psychiatric effects by the rhizomes of Alpinia officinarum on complete freund’s adjuvant-induced arthritis in rats
- Estrogen receptor alpha was activated by MAPK and PI3K phosphorylation pathway in hypoxia
- Preparation and characterization of Doxorubicin-loaded Albumin nanoparticles conjugated with an apoptotic protein and a cell targeting ligand
- Anthocyanin and phenolics from red pepper leaves
- Isopsoralen induction of pre-chondrogenic ATDC5 cell differentiation via activation of MAP kinases pathway
- Intestinal dendritic cells could survey circulatory antigen.
- Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-κB, NFATc1 and c-Fos
- Construction of thiazolo[4,5-b]pyridine library by using a solid-phase synthesis protocol
- Saucerneol F inhibits iNOS expression via MAPKs, NF-kB and AP-1 inactivation in LPS-stimulated RAW 264.7 cells
- Inhibitors of adipogenesis in 3T3-L1 cells isolated from the aerial parts of Agrimoniae pilosa
- Research on chemical constituents of soft coral Sarcophyton elegans in the sea Vietnam
- Furanyl benzofuropyridine derivatives as novel anticancer agents that inhibit catalytic activity of topoisomerase IIα an induce G1 arrest in breast cancer cells
- Novel anti-platelet activity of lonicera flos and its bioacitve ingredient through inhibition of shear stress-induced platelet aggregation
- Choline kinase targeted siRNA in PEGylated Liposome for Breast Cancer Therapy In vivo
- Neuroprotective effects of Eucommia ulmoides Oliv. Bark. on cognitive deficit and neuronal cell death in in vivo and in vitro models
- Simultaneous quantification monitoring and physiolosical activities of compounds from Peucedani Radix
- Inhibitory effects of Platycodon grandiflorum A. de Candolle on 3T3-L1 adiopocyte differentiation
- Identification of oral Cholerae vaccine Strains by multiplex PCR
- Inhibitory effects on A2E photooxidation of natural antioxidants
- Development of a simple, rapid and sensitive LC-MS/MS method for the determination of lamivudine in human plasma
- Influence of fimasartan on catecholamine secretion from the isolated rat adrenal medulla
- The correlation between drug-induced bradycardia in zebrafish and hERG channel blockage by fluorescence polarization assay and patch clamp assay.
- Immunoregulatory effect of 18-glycyrrhetinic acid in mice
- Diphlorethohydroxycarmalol, isolated from the brown algae ishige okamurae, increases the prostaglandin e2 through activation of Cyclooxygenase-1 expression in HaCaT human keratinocytes
- N-Methylthioureas as new agonists of retinoic acid receptor-related orphan receptor α
- A novel 3,4-dihydropyrimidin-2(1H)-one: HIV-1 replication inhibitors with improved metabolic stability
- Takeda's strategy, -past, present, & future-
- Evaluation of in vitro and in vivo anti-melanogenic activity of a newly synthesized strong tyrosinase inhibitor (E)-3-(2,4 dihydroxybenzylidene) pyrrolidine-2,5-dione
- Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines
- A fraction of methylene chloride from Chrysanthemum indicum L. induces apoptosis through suppression of constitutive STAT3 activation in human prostate cancer DU145 cells
- Structure of the ORD domain of yeast OSBP reveals a conserved mode of ligand binding in oxysterolbinding protein families?
- Serum kinetics, distribution and excretion of silver in rabbits following 28 days after a single intravenous injection of silver nanoparticles
- Development of thermo-sensitive injectable hydrogel with sustained release of doxorubicin
- KR-66344, a novel selective 11β-HSD1 inhibitor, inhibit the LPS-induced inflammation in J774.1 macrophages
- PHB72 inhibits rat aortic smooth muscle cell proliferation through suppressing PDGFRβ phosphorylation
- High-throughput combinatorial synthetic technology in drug discovery: construction of fused-thiazole library on solid-phase
- Protective effect of native plant hot water extract on the tunicamycin induced enoplasmic rticulum stress
- Management status and advancement strategies of national reference standards
- Quality issue and considerations in the herbal medicinal product development
- GMP & validation of traditional Korean medicine
- Animal models center for drug discovery and development
- Departing conventional particle shape for improved drug delivery
- Korean medical education: Past, present and future
- Cortical gene expression changes in acute and chronic morphine addiction
- Effect of mixture extracts of herbs on hyperlipidemia in rats fed high fat diet
- Comparative study of SR 823, standarized fraction of salvia miltiorrhiza and its major components; cryptotanshinone, Tanshinone I and Tanshinone IIA for induction of apoptosis on activated rat hepatic stellate cells
- Impairment of hypoxia-induced endothelial progenitor cell function in angiotensinogen knockout mice.
- The roles of microRNA-382 induced by hypoxia in angiogenesis
- AKT regulates DLX3 during osteoblastogenesis
- Identification of cellular regulatory changes upon Anthrax toxin induction on HAEC by microarray analysis
- Roles of vascular progenitor cells in cardiovascular problems in metabolic syndrome
- The Role of P2Y6 receptor on osteoclast formation
- Tumor evasion mechanism employing PD-1/PD-L1 interactions is subdued by PD-1 Ig
- Heterocycle-linked constrained phenylbenzyl amides as novel TRPV1 antagonists with improved pharmacological properties and insight into their TRPV1 binding mode
- 2-(4-Methylsulfonylaminophenyl)propanamide TRPV1 antagonists : structure activity relationships in the C-regions
- Homology modeling and docking analysis of G-protein coupled receptor 120, a promising target for the treatment of obesity and metabolic disorders
- Structural and molecular modeling studies of the selective phosphatidylinositide 3-Kinase inhibitors
- Antimicrobial effect of honey bee (Apis mellifera) venom against Propionibacterium acnes
- Simultaneous quantitation of seven marker compounds in Lingzhi by HPLC
- Dispersive liquid-liquid microextraction based on solidification of floating organic droplet followed by high performance liquid chromatography for the determination of duloxetine in human plasma
- Biophysical stability assessment of protein formulations by differential scanning calorimetry
- Tumor targeted delivery of liposomal photosensitiser for cancer treatment
- Improved biological half-life and anti-tumor activity of Apo2L/TRAIL using PEG-exposed nanoparticles
- Acute effects of KR-67829, a novel DGAT 1 inhibitor, on triglyceride and cholesterol in the tallyho/jnj polygenic mouse model
- Formation and evaluation of solid lipid nanoparticles of water soluble drug: gensenoside Rg1, Rb1
- Epidermal growth factor-containing chitosan hydrogel for gastrointestinal-ulcer coating and healing
- Similar or not: economic evaluation and reimbursement decision of 4 countries(Australia, UK, Canada, and Korea)
- Pharmacokinetics and correlation analysis of cilostazol in Korean healthy subjects
- The development of e-learning programs on regulatory affairs related with drug, medical device, functional food and cosmetics
- The guideline on the non-clinical document of herbal medicinal products
- Multiscreening center for drug development: Our mission, goals and achievements
- Thiacremonone chemosensitizes human lung cancer cells to paclitaxel by targeting of NF-κB.
- The new challenges of official compendium in 2012
- Global approval strategies of finished products
- Strategy to cope with regulatory issues and challenges in developing botanical drugs in the US
- The risk and benefit assessment of new drug clinical trial in Chinese traditional medicine
- Sargaquinoic acid isolated from sargassum siliquastrum suppresses the expression of inducible nitricoxide synthase in lipopolysaccharide-stimulated RAW264.7 macrophages
- The effect of motilitone on the spontaneous activity of circular smooth muscle in feline stomach
- Anti-acne effects of HCAT, the extract of herbal complex
- The effect of Quercus salicina leaf extract on vascular endothelial function: role of nitric oxide
- Inhibitory effect of adiponectin on NADPH oxidase expression induced by ethanol in RAW264.7 Macrophages
- Inhibitory effects of black soybean on platelet activation mediated through its active component of adenosine
- Neuroprotective effects of SMB-1 against DA-induced apoptosis and ROS production on neroblastoma SH-SY5Y cells
- Interleukin-17, a novel regulator of TPL2, induced AP-1 activity and cellular transformation in JB6 CL41 cells
- Pharmacokinetics of Verapamil and its metabolite Norverapamil in Hyperlipidaemic rats induced by Poloxamer 407
- Antigen-induced degranulation inhibitory effect of norlignan derivatives
- Osmotin, a plant stress-induced protein, mimics the activity of adiponectin in animal and yeast
- 제주 용암해수의 산업화 전략
- The effect of octaphlorethol A, a component from Ishige sinicola on the prevention of hair-loss
- Past, current, and future of drug discovery from natural products in the pharmaceutical industry
- Increased oxidative stress with aging plays important roles to increase vulnerability in experimental autoimmune encephalomyelitis
- the wound-healing effect of a hydrocolloid wound dressing containing Benzalkonium chloride
- Enantioselectivity of Inhibition of Ginsenosides Rg3 and Rh2 on Cytochrome P450 enzyme activities
- NGF facilitates depolarization-induced NFAT activation via the PI3K-Akt-GSK3 pathway to regulate pain-related gene expression in DRG sensory neurons
- Regulation of hepatocyte nuclear factor 4 alpha by a novel naphtofuran derivative compound in liver cancer cell.
- Role of essential phosphatidylcholine against cisplatin-induced renal toxicity and oxidative stress in rats
- Asymmetric synthesis of D-Fagomine using chlorosulfonyl isocyanate.
- Approval and post-approval surveillance of quasi-drugs
- Two new sesquiterpenes from Atractylodes japonica rhizomes and inhibitory compounds on nitric oxide production in macrophage RAW264.7 cells
- Adverse drug reaction signal detection research using administrative data for public insurance
- Anticancer activity of Docetaxel micelle-encapsulated using a tripodal cyclotriphosphazene amphiphile
- A new steroid-type compound from the leaves of Daphne kiusiana
- Evaluation of bromo-retrochalcone derivatives as peroxisome proliferator-activated receptor gamma(PPARγ) Activators
- Asymmetric transformation of L-homoserine lactone to an optically active 2-substituted pyrrolidine for clemastine
- Comparative study of SR 823, standarized fraction of salvia miltiorrhiza and its major components; cryptotanshinone, Tanshinone I and Tanshinone IIA for induction of apoptosis on activated rat hepatic stellate cells
- Inhibiting IL-4 signaling pathway in antigen stimulated RBL-2H3 mast cells by an active phytocompound
- Conditioned place preference studies with Zoletil？？: effects of repeated drug treatment
- Glutathione conjugation of benzyl and ethyl bromide in rats
- Duloxetine blocks cloned Kv4.3 potassium channels
- Development of an UPLC method for the determination of residual arsenic compounds in chicken muscle using pre-column derivatization with toluene-3,4-dithiol
- Isolation a heterotrophic halophilic gram-positive bacteria from a solar saltern in korea
- Identification and evaluation of endogenous metabolic markers for CYP3A activity using untargeted & targeted metabolomics
- PPAR α/γ dual agonist modulates UVB-induced inflammation in skin through inhibiting NF-κB
- Current activity as an inpatient anticoagulation specialist
- KFDA's recent trends for drug quality review
- Identification of alkaloids from the seeds of sacred lotus (Nelumbo nucifera) using DART-TOF-MS and UPLC-ESI-TOF-MS.
- Effect of pregnancy on the pharmacokinetics, placenta and brain uptake of paclitaxel and taurine in rat model
- Investigation on chemical constituents from the bud of Triticum aestivum
- Enhancing cartilage regeneration by electrospun TGF-β loaded 3-D Poly(L-lactic acid) scaffold
- Advanced glycan analysis using Chip-MS technology
- Keynote presentation
- Simultaneous qualitative and quantitative analysis of buspirone and its metabolites with the Agilent 6550 iFunnel Q-TOF LC/MS system
- Joint efforts of colleges of medicine and pharmacy for education: A case of Yonsei University
- Need for community pharmacy residency program
- Current address for the harmonization of the regulatory system in drug approval and searching for future perspectives
- Agilent solutions for multi-purpose LC analysis for pharmaceutical laboratories
- Elevating the regulatory profession in Korea
- Association between tissue-type plasminogen activator (tPA) and/or plasminogen activator inhibitor type-1 (PAI-1) and warfarin responses
- Protein tyrosine phosphatase-1β inhibitory compounds from purple corn kernel
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