ALA 및 ALA-Methylester의 투여에 따른 종양조직 및 정상조직에의 분포양상에 대한 연구

• 영문명: Distribution Patterns in the Tumor Tissue and Normal Tissue according to the Administration Methods of ALA and ALA-Methylester
• 발행기관: 대한두경부종양학회
• 저자명: 정필상(Phil-Sang) 정상운(Sang Oun Jung) 안진철(Jin Chul Ahn) 이상준(Sang Joon Lee) 윤준식(Jun Sik Yoon)
• 간행물 정보: 『대한두경부종양학회지』제19권 제1호, 21~24쪽, 전체 4쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2003.05.30

영문 초록

Objectives: In this report, we confirmed the distributed pattern of ALA and ALA-methylester in normal and tumor-bearing region. Materials and Methods: ALA and ALA-methylester were administered to nude mouse by intratumoral, subcutaneous and intravenous injection. After injection, the fluorescence in normal and tumor region was measured by LESA (laser electronic spectrum analyzer). Results: The tumor-specificity of ALA and ALA-methylester was shown in the case of intratumoral injection. In all case, the fluorescence caused by ALA and ALA-methylester was maximally increased in 2 hours after injection. Then while the fluorescence level was rapidly decreased to control level in normal region, it was still remained in tumor region. Conclusion: According to this result, The intratumoral injection was more efficient administration method for PDT/PDD than subcutaneous and intravenous injection.

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키워드

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