비인강암의 세기조절방사선치료기술을 이용한 동시차등조사가속치료의 예비성적

• 영문명: "Simultaneous Modulated Accelerated Radiation Therapy" (SMART) Intensity-Modulated Radiotherapy in the Treatment of Nasopharyngeal Carcinoma : the Asan Medical Center
• 발행기관: 대한두경부종양학회
• 저자명: 이상욱(Sang wook Lee) 백금문(Geum Mun Back) 이병용(Byong Yong Yi) 최은경(Eun Kyung Choi) 김종훈(Jong Hoon Kim) 안승도(Seung Do Ahn) 신성수(Seong Soo Shin) 김상윤(Sang Yoon Kim) 남순열(Soon Yuhl Nam) 최승호(Seung Ho Choi) 김성배(Sung Bae Kim) 송시열(Si yeol Song)
• 간행물 정보: 『대한두경부종양학회지』제19권 제1호, 9~15쪽, 전체 7쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2003.05.30

영문 초록

Purpose: To introduce our early experience with intensity-modulated radiotherapy (IMRT) in the treatment of nasopharyngeal carcinoma. Methods and Materials: Eight patients who underwent IMRT for no disseminated nasopharyngeal carcinoma at the Asan Medical Center between September 2001 and November 2002 were evaluate by prospective analysis. According to the 1997 American Joint Committee on Cancer staging classification, 5 had Stage III, and 3 had Stage IVB disease. The IMRT plans were designed to be delivered as a 'Simultaneous Modulated Accelerated Radiation Therapy' (SMART) using the 'step and shoot' technique with a MLC (multileaf collimator). Daily fractions of 2.2-2.5Gy and 1.9-2Gy were prescribed and delivered to the GTV and CTV and clinically negative neck node, respectively. The prescribed dose was 70A-79.0Gy to the gross tumor volume (GTV), 60Gy to the clinical target volume (CTV) and metastatic nodal station, and 46Gy to the clinically negative neck. All patients also received weekly cisplatin during radiotherapy. Acute and late normal tissue effects were graded according to the Radiation Therapy Oncology Group (RTOG) radiation morbidity scoring criteria. Results: Follow-up period was ranging from 5 to 18 months. All patients showed complete response and loco-regional control rate was 100% but one patient died of malnutrition due to treatment related toxicity. There were no Grade 3 or 4 xerostomia and all patients had experienced improvement of salivary gland function. Conclusion: 'Simultaneous Modulated Accelerated Radiation Therapy' (SMART) boost intensity-modulated radiotherapy technique allows parotid sparing as evidenced both clinically and by dosimetry. Initial tumor response and loco-regional control was promising. It is clinically feasible. A larger population of patients and a long-term follow-up are needed to evaluate ultimate tumor control and late toxicity.

목차

Abstract

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대상 및 방법

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키워드

비인강암 동시항암화학방사선치료 Nasopharyngeal carcinoma IMRT CCRT