진행된 두경부암에서의 항암방사선 동시요법의 치료효과

• 영문명: Concomitant Chemoradiotherapy as Primary Therapy for Advanced Head and Neck Cancer
• 발행기관: 대한두경부종양학회
• 저자명: 이주연(Joo Yun Lee) 이동욱(Dong Wook Lee) 최영석(Young Seok Choi) 진홍률(Hong Ryul Jin) 이현석(Hyun Seok Lee) 연제엽(Je Yeob Yeon) 신시옥(See Ok Shin)
• 간행물 정보: 『대한두경부종양학회지』제18권 제2호, 163~167쪽, 전체 5쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2002.11.30

영문 초록

Background: To achieve the efficacy and toxic effects of concomitant FP chemoradiotherapy regimen by means of response and survival in patients with advanced head and neck cancer. Patient and Method: Thirty-three previously untreated patients with newly diagnosed advanced head and neck cancer were retrospectively reviewed. Results: Thirty-one patients were evaluable for the tumor response. Total response rate was 93%(complete response 60%, partial response 33%). Disease free survival was 37 month and 3-year overall survival was 63%. Grade 3 or 4 stomatitis was observed in 83% and appeared as the dose limiting toxicity for this regimen. Conclusion: Concomitant chemoradiotherapy with cisplastin and 5-fluorouracil is effective as primary therapy for advanced head and neck cancer. The majority of patients experienced severe stomatitis. Identification of less toxic regiment and improved disease control emerge as important future research goals.

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대상 및 방법

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키워드

진행된 두경부암 항암방사선 치료 Chemoradiotherapy Advanced head and neck cancer