두경부 선양낭성암종에서 원격전이와 관련된 임상적, 병리학적 예측 인자

• 영문명: Clinicopathologic Predictors and Impact of Distant Metastasis from Adenoid Cystic Carcinoma of the Head and Neck
• 발행기관: 대한두경부종양학회
• 저자명: 김정훈(Jeong Whun Kim) 김광현(Kwang Hyun Kim) 성명훈(Myung Whun Sung) 권택균(Taek Kyun Kwon) 이상준(Sang Joon Lee)
• 간행물 정보: 『대한두경부종양학회지』제18권 제2호, 157~162쪽, 전체 6쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2002.11.30

영문 초록

Background and Objectives : Adenoid cystic carcinoma (ACC) is a unique tumor characterized by frequent and delayed distant metastasis (DM) with uncommon regional lymph node metastasis. We evaluated the factors affecting DM of ACC and survival after appearance of DM. Materials and Methods : Medical records, radiographs and pathologic slides were reviewed for 94 patients from 1979 through 2001. Results : DM of ACC occurred in 46 patients, and developed more frequently in patients with tumors of the solid histologic subtype than in patients with tubular or cribriform subtypes. DM occurred less frequently in the sinonasal tract, and development of DM was not affected by tumor stage. Disease-specific 5- and 10-year survival rates were 88% and 72% for patients without DM, respectively and 76% and 48% for those with DM (p=0.02). Regarding the site of DM and its impact on outcomes, 30 patients had lung metastasis alone, 5 patients bone metastasis alone and 6 patients developed both lung and bone metastasis. Median survivals after appearance of DM among patients with isolated lung metastases and those with bone metastases with or without lung involvement were 54 and 21 months, respectively (p=0.04). Conclusions : Development of DM in ACC is predicted by solid histologic subtype, and major salivary gland or oral/pharyngeal rather than sinonasal primary site. Those patients with bone involvement with our without lung metastases had worse outcomes than those with pulmonary metastasis only.

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키워드

두경부 종양 선양낭성암 원격전이 비부비동 계통 생존율 Head and neck Adenoid cystic carcinoma Distant metastasis Sinonasal tract Survival rate