진행된 하인두암에서 유도항암화학요법 후 방사선치료의 결과

• 영문명: Treatment Outcome after Induction Chemotherapy Followed by Radiation Therapy in Locally Advanced Hypopharyngeal Cancer
• 발행기관: 대한두경부종양학회
• 저자명: 송시열(Si Yeol Song) 김성배(Sung Bae Kim) 김상윤(Sang Yoon Kim) 남순열(Soon Yuhl Nam) 최은경(Eun Kyung Choi) 김종훈(Jong Hoon Kim) 안승도(Seung Do Ahn) 제형욱(Hyoung Uk Je) 이상욱(Sang-Wook Lee)
• 간행물 정보: 『대한두경부종양학회지』제24권 제2호, 162~168쪽, 전체 7쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2008.11.30

영문 초록

Purpose ：To know the results after induction chemotherapy followed by curative radiation therapy for locally advanced hypopharyngeal cancer Methods and Materials ：From August 1990 to December 2003, forty patients who were treated with in-duction chemotherapy and curative radiation therapy were analyzed retrospectively. Median age of patients was 60 years(range：40-78 years) and clinical stage was wholly stage 3 or 4. Induction chemotherapy used cisplatin with 5-FU or docetaxel, and its interval was 3 weeks. Irradiated radiation dose was 70 to 78Gy (median：70.8Gy). Results ：Median follow-up time was 39.4 months(range：8-115 months). Treatment failures were ob-served in 52.5% patients, and main failure pattern was local recurrence in 16 patients. 3 and 5 year disease free survival were 52.6%, 48.2% respectively and values of overall survival were 60.0, 43.9% and median survival time was 44.7 months. Treatment response was only a prognostic factor for survival. Laryngeal preservation was observed in twenty-four(60.0%) patients. Conclusion ：Initial primary tumor stage was a significant prognostic factor for laryngeal preservation, and response after radiation therapy was a prognostic factor for long-term survival after induction chemotherapy followed by curative radiation therapy for locally advanced hypopharyngeal cancer.

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대상 및 방법

결 과

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키워드

Hypopharyngeal cancer Induction chemotherapy Radiation therapy Larynx preservation 하인두암 유도항암화학요법-방사선치료 성문 부 보존.