새로운 Fluoronaphthyridinone계 항균제 DW286의 그람 양성세균에 대한 항균 활성

• 영문명: In vitro and In vivo Activity of DW286, an Experimental Fluoronaphthyridione, against Gram-Positive Bacteria
• 발행기관: 대한약학회
• 저자명: 곽진환(Jin-Hwan Kwak) 박희수(Hee Soo Park) 정성지(Sung Ji Jung) 정지웅(Ji-Woong Jeong) 김요셉(Joseph Kim) 최동락(Dong-Rack Choi) 최응칠(Eung-Chil Choi)
• 간행물 정보: 『약학회지』제56권 제5호 (2012년), 304~308쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.10.31

영문 초록

In vitro antibacterial activity of DW286 was tested against recently collected clinical isolates of Gram-positive strains by the two fold agar dilution method. In vivo activity of DW286 was also determined against systemic infections in mice caused by Staphylococcus aureus. DW286 showed 16~64-fold more potent in vitro activities than ciprofloxacin against Gram-positive bacteria. Against systemic infection model caused by two S. aureus strains, one being methicillin-susceptible and the other methicillin-resistant, DW286 (ED50s, 0.16 mg/kg and 4.36 mg/kg, respectively) was more potent than gemifloxacin (1.37 mg/kg, 26.58 mg/kg, respectively).

키워드

DW286 fluoroquinolone MIC ED50