Synthesis of Pateamine A Derivatives for Putative Cellular Receptor Isolation and Structure Activity Studies

• 발행기관: 대한약학회
• 저자명: Nam Song Choi
• 간행물 정보: 『춘계총회 및 학술대회』(2004년) vol.1, 65~66쪽, 전체 1쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2004.04.30

영문 초록

Molecules that inhibit the immune responses by blocking a specific signaling pathway involved in T-cell activation have proven to be useful biochemical tools. In this regard, molecules such as FK-506, cyclosporin A and rapamycin have aided in the elucidation of pathways which trigger the immune response as well as molecules involved along the signaling pathway .으 Pateamine A, a potent immunosuppressant isolated from the M ycale species sponge, was found to inhibit an intracellular step of the T-cell receptor signal transduction pathway leading to EL-2 production. Although the detailed signaling pathway affected by pateamine A has not been determined, pateamine A is an attractive candidate for use as a biological probe in the study of T-cell signaling pathways, and thus the isolation of its putative cellular receptor may provide a novel therapeutic target for intervention in autoimmnue diseases.

목차

1. Introduction

2. Background

3. Objective and Result