백내장 수술 전후 0.05% 사이클로스포린 점안이 눈물막 및 각막수차에 미치는 영향

• 영문명: Effect of Cyclosporin A on Tear Film and Corneal Aberration after Cataract Surgery
• 발행기관: 대한안과학회
• 저자명: 전제훈 김홍석 정지원 윤상철 서경률 이형근 김응권 김태임,Jei Hun Jeon, MD, Hong Seok Kim, MD, Ji Won Jung, MD, Sang Chul Yoon, MD, Kyoung Yul Seo, MD, PhD, Hyung Keun Lee, MD, Eung Kweon Kim, MD, PhD, Tae Im Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number7, 978~983쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.07.15

영문 초록

Purpose: To evaluate the efficacy of 0.05% cyclosporine A on tear film parameters and corneal aberration after cataract surgery. Methods: Patients who underwent cataract surgery were divided into 2 groups. Patients in Group I (23 eyes) were treated with cyclosporine A from 1 week before surgery to 3 months after surgery. Patients in Group II (24 eyes) underwent surgery without cyclosporine treatment. Tear film break-up time (BUT), Schirmer’s test I, Oxford scheme, Ocular surface disease index (OSDI), and corneal aberrations were evaluated before surgery and at 1 and 3 months after surgery. Results: In Group I, BUT was significantly improved at 3 months (p = 0.026) after surgery compared with the preoperative value. OSDI decreased significantly at 1 (p = 0.033) and 3 months (p = 0.003) after surgery compared with the preoperative value. However, there were no significant differences between preoperative and postoperative values of BUT and OSDI in Group II. Schirmer’s test results and the Oxford scheme were not significantly changed in either group. Preoperative root mean square (RMS) total values were not different between the 2 groups, but was different at postoperative 3 months (p = 0.015). Group I had a significantly lower value for total RMS than Group II. In Group I, Coma 7 (Z3-1) (p = 0.018) and spherical aberration (Z4 0) (p =0.031) were significantly decreased after surgery. In Group II, Trefoil 6 (Z3-3) (p = 0.033) was significantly increased after surgery. Conclusions: 0.05% cyclosporine A may be effective for improving dry eye syndrome and corneal aberration after cataract surgery. J Korean Ophthalmol Soc 2014;55(7):978-983

키워드

Cataract surgery, Corneal aberration, Cyclosporin, Dry eye