신경매독과 연관되어 발생한 안매독의 임상 양상

• 영문명: Clinical Manifestations of Ocular Syphilis Combined with Neurosyphilis
• 발행기관: 대한안과학회
• 저자명: 조용운 김체론 한용섭 정인영 박종문,Yong Wun Cho, MD, Che Ron Kim, MD, Yong Seop Han, MD, PhD, In Young Chung, MD, PhD,Jong Moon Park, MD, PhD,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number4, 602~607쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.04.15

영문 초록

Purpose: To report the manifestation of ocular syphilis combined with neurosyphilis in patients who present with uveitis clinically and are diagnosed initially by an ophthalmologist. Methods: This study is a retrospective, clinical investigation of seven male patients with ocular syphilis from a single tertiary center between 2009 and 2012. Results: The average age of the patients at onset was 44.4 years (range, 33-71 years). Posterior segment involvement was found in all patients. Two patients had papillitis. In serologic testing, all patients had positive responses to Venereal Disease Research Laboratory (VDRL), fluorescent treponemal antibody-absorption test (FTA-ABS) and Treponema pallidum hemagglutination (TPHA). In fluorescein angiography (FAG), retinal vascular and disc leakage was the most common finding. Cerebrospinal fluid (CSF) analysis was performed for six patients and demonstrated positive CSF FTA-ABS and CSF TPHA tests in all patients. CSF VDRL was reactive in 2 patients (33.3%). Conclusions: All patients with ocular syphilis were diagnosed with neurosyphilis based on the analysis of CSF with FTA-ABS and TPHA. Ophthalmologists play an important role in the early diagnosis and treatment of syphilis. J Korean Ophthalmol Soc 2014;55(4):602-607

키워드

CSF analysis, Neurosyphilis, Ocular syphilis