한국의 매독 포도막염의 임상양상

• 영문명: Clinical Manifestations of Syphilitic Uveitis in the Korean Population
• 발행기관: 대한안과학회
• 저자명: 곽현덕 김현웅 이지은 이주은 이상준 윤일한,Hyun Duck Kwak, MD, Hyun Woong Kim, MD, PhD, Ji Eun Lee, MD, PhD, Joo Eun Lee, MD, PhD,Sang Jun Lee, MD, PhD, Il Han Yun, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number4, 555~562쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.04.15

영문 초록

Purpose: In recent, years, an increase of syphilis infections has become an issue in Korea as well as globally. Herein, we report a recent clinical manifestation of syphilitic uveitis in a Korean population.
Methods: Over a 5-year period (2007-2012), we collected and analyzed the medical records of 16 patients with syphilitic uveitis in three tertiary eye clinics in Pusan. Sixteen patients were confirmed to have syphilis based on serological tests. Retrospective chart review was performed to determine the best corrected visual acuity, anterior and posterior segments, and treatment regimen, as well as ancillary test results including fluorescein angiogram (FAG).
Results: Of the 16 patients, 12 were males and four were females. The mean age of the patients was 51.16 years. Non-granulomatous anterior uveitis was observed in nine eyes (47.4%). Vitritis was the most frequently observed posterior segment finding (16 eyes, 84.2%). Retinal vasculitis and chorioretinitis were found in 11 (57.9%) and five eyes (26.3%), respectively. All patients had negative results in the serum HIV antibody test. Of the 16 patients, 15 were treated with penicillin or ceftriaxone due to neurosyphilis. Mean visual acuity improved from 1.33 ± 1.1 to 0.58 ± 0.68 after treatment.
Conclusions: Clinical manifestation of syphilitic uveitis in Korean patients is different from occurrences in Western countries. Ophthalmological findings of syphilitic uveitis are diverse; thus, serological testing for syphilis is recommended for all uveitis patients. Further research regarding long-term treatment, relapse of syphilitic uveitis, and complications is necessary.
J Korean Ophthalmol Soc 2014;55(4):555-562

키워드

Human immunodeficiency virus, Syphilis, Uveitis