당뇨망막병증에서 유리체강내 베바시주맙 주사 후 망막미세혈관류의 변화

• 영문명: The Change of Microaneurysm in Diabetic Retinopathy Patients Who Undergo Intravitreal Avastin (Bevacizumab) Injection
• 발행기관: 대한안과학회
• 저자명: 최창욱 이승준 강혜라 양연식,Chang Wook Choi, MD, Seung Joon Lee, MD, Hye Ra Kang, MD, Yun Sik Yang, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number10, 1481~1486쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.10.15

영문 초록

Purpose: To evaluate microvascular change (microaneurysm) in diabetic retinopathy patients who undergo intravitreal bevacizumab injection using fluorescein angiography (FAG). Methods: Thirty one eyes of 31 diabetic retinopathy patients undergoing intravitreal bevacizumab injection (1.25 mg/0.05 mL) in only 1 eye were included in this study. The control group (31 eyes) consisted of the fellow eyes. We excluded cased with intravitreal bevacizumab injection in both eyes and medial opacity obscuring three fundus image due to vitreous hemorrhage. The microaneurysmal change was analyzed at the same site the circle with optic disc radius and macula using FAG 2 to 4 months after injection. Results: The average number of microaneurysms was 42.58 ± 33.93 and significantly decreased to 28.74 ± 28.06 after intravitreal bevacizumab injection (p < 0.05). The decrease of 35.70 ± 24.79% in the treatment group was statistically higher than 13.95 ± 38.21% in the control group with the fellow eyes (p < 0.05). Conclusions: In the present study, intravitreal bevacizumab injection reduced neovascularization, cystoid macular edema. Therefore this data can be used for future research on microvascular changes in the retina. J Korean Ophthalmol Soc 2014;55(10):1481-1486

키워드

Bebacizumab (Avastin), Diabetic retinopathy, Vascular endothelial growth factor (VEGF)