유병기간이 짧은 눈물길 협착 환자에서 점안 스테로이드제의 효과에 관한 연구

• 영문명: The Effectiveness of Topical Steroid Instillation in Patients with Recently Developed Nasolacrimal Drainage Stenosis
• 발행기관: 대한안과학회
• 저자명: 김용대 김남주 정호경 곽상인,Yong Dae Kim, MD, Nam Ju Kim, MD, Ho Kyung Choung, MD, Sang In Khwarg, MD,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number10, 1418~1425쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.10.15

영문 초록

Purpose: To evaluate the effectiveness of topical steroid instillation and associated factors in patients with recently developed nasolacrimal drainage stenosis. Methods: The medical records of 108 eyes of 56 patients who received topical steroid for nasolacrimal drainage stenosis between January 2010 and June 2013 and who developed epiphora of a three-month duration were retrospectively reviewed. Evaluations were performed at 1, 3, and 6 months after instillation of topical steroid. Subjective symptoms, tear meniscus height, and fluorescein dye disappearance test results were noted at every follow-up visit; nasolacrimal irrigation and canalicular probing were also performed as needed. Results: The cumulative improvements were 42.0% at 1 month and 51.0% at 3 months after treatment, and the mean period of symptomatic improvement was 3.8 ± 1.9 weeks (range, 3-12 weeks). At the final follow-up visit, 56 (51.9%) of 108 eyes showed improved epiphora. Final improvement was observed in 63% (12 of 19 eyes) of idiopathic nasolacrimal drainage stenosis patients, in 100% (10 of 10 eyes) of docetaxel-treated patients, and in 43% (34 of 79 eyes) of S-1-treated patients. Conclusions: Instillation of topical steroids can be effective for nasolacrimal drainage stenosis and may prevent the need for invasive surgical treatment. J Korean Ophthalmol Soc 2014;55(10):1418-1425

키워드

Docetaxel, Epiphora, Nasolacrimal drainage stenosis, S-1, Topical steroid