Oxaliplatin에 의한 안독성의 1예

• 영문명: A Case of Oxaliplatin-Related Ocular Toxicity
• 발행기관: 대한안과학회
• 저자명: 박한석 김양재 송수정 배정훈,Han Seok Park, MD, Yang Jae Kim, MD, Su Jeong Song, MD, Jeong Hun Bae, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number1, 143~148쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.01.15

영문 초록

Purpose: To report a case of oxaliplatin (Eloxatin^{®)-related ocular toxicity in a patient with advanced stomach cancer. Case summary: A 43-year-old female with advanced stomach cancer experienced visual symptoms during the treatment with oxaliplatin on a XELOX schedule (a combination of oxaliplatin and capecitabine). After 1 cycle of chemotherapy, she complained of blurred vision and visual field defects in both eyes. Visual field tests showed a bilateral concentric field defect and the electroretinogram revealed a marked reduction of responses in both eyes. On the second cycle of chemotherapy, oxaliplatin was discontinued due to suspicious ocular toxicity. Her visual symptoms improved and visual field test showed normal results 1 month after oxaliplatin discontinuation. However, 3 months after oxaliplatin discontinuation, electroretinogram remained abnormal despite the progressive improvement. Conclusions: Platinum-based antineoplastic agents such as oxaliplatin should be administered with caution because oxaliplatin can cause damage to the retinal photoreceptors and the optic nerve. Early detection of ocular toxicity and discontinuation of oxaliplatin therapy could prevent severe and irreversible visual loss. J Korean Ophthalmol Soc 2014;55(1):143-148}

키워드

Electroretinogram, Ocular toxicity, Oxaliplatin, XELOX