잠복 맥락막신생혈관을 동반한 나이관련황반변성에서 베바시주맙 단독치료와 광역학요법 병합치료

• 영문명: Bevacizumab Monotherapy Versus Combined Therapy with Photodynamic Therapy for Occult Choroidal Neovascularization in Age-Related Macular Degeneration
• 발행기관: 대한안과학회
• 저자명: 오종현 김성우 오재령 권순선 허걸,Jong-Hyun Oh, MD, PhD, Seong-Woo Kim, MD, PhD, Jaeryung Oh, MD, PhD,Soon-Sun Kwon, PhD, Kuhl Huh, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number10, 1554~1560쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.10.15

영문 초록

Purpose: To compare clinical outcomes between intravitreal bevacizumab (IVB) monotherapy and combined therapy with half-fluence rate verteporfin photodynamic therapy (PDT) for occult choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Methods: Medical records were reviewed in consecutive patients who underwent IVB monotherapy or combined therapy with PDT for occult CNV secondary to AMD and had a 12-month follow-up period. After 3 consecutive monthly IVB injections, both groups were eligible for additional IVB injections when necessary. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and number of additional IVB injections were compared between the groups. Results: Thirty-nine eyes underwent IVB monotherapy (IVB group) and 25 eyes underwent combined therapy (PDT+IVB group). Mean BCVA improved significantly in the PDT+IVB group (p = 0.046) and not in IVB group (p = 0.213). A significant reduction in mean CMT occurred in both groups (p < 0.001). The mean number of additional IVB injections was 1.6 ± 1.33 in the IVB group and 0.5 ± 1.01 in the PDT+IVB group (p = 0.001). There were no serious complications. Conclusions: Combined therapy with half-fluence rate PDT improved BCVA and reduced the number of additional IVB injections in the eyes with occult CNV secondary to AMD.

키워드

Age-related macular degeneration, Bevacizumab, Occult choroidal neovascularization, Photodynamic therapy