수입공여각막의 내피세포감소에 영향을 미치는 인자에 대한 분석

• 영문명: Analysis of Factors Affecting the Decrease of Endothelial Cell Density in Imported Donor Corneas
• 발행기관: 대한안과학회
• 저자명: 공석준 조경진 김만수,Seok Joon Kong, MD, Kyongjin Cho, MD, Man Soo Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume53,number1, 20~26쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.01.15

영문 초록

Purpose: To evaluate the difference between corneal endothelial cell density at the moment of preservation and at keratoplasty in imported donor corneas and to analyze the correlated factors of the difference. Methods: Eighty-seven imported corneas were evaluated. Corneal endothelial cell density at the moment of preservation was obtained from the medical record and was measured just before the keratoplasty. Correlation of the difference in endothelial cell density with the following factors were analyzed; donor sex, donor age, death-to-preservation time, preservation- to-surgery time, death-to-surgery time, endothelial cell density at the moment of preservation, and preservation period of the corneas. Results: All of the corneas showed a decrease in endothelial cell density. Mean endothelial cell density of imported donor corneas at the moment of preservation and at keratoplasty was 2789 ± 235 cells/mm2 and 2592 ± 254 cells/mm2 (p ＜0.001), respectively. Mean endothelial cell loss was 197 ± 148 cells/mm2, which was significantly correlated with preservation-tosurgery time, death-to-surgery time and a preservation period longer than 7 days (p = 0.042, p = 0.045, p = 0.036, respectively). Conclusions: Reduced death-to-surgery time and keratoplasty before 7 days of preservation are needed for better surgical outcome. J Korean Ophthalmol Soc 2012;53(1):20-26

키워드

Death to surgery time, Endothelial cell density, Imported donor corneas