맥락막신생혈관을 동반한 광범위한 망막하출혈환자에 대한 삼중치료 효과

• 영문명: The Effect of Triple Therapy on Patients with Subretinal Hemorrhage Accompanied by Choroidal Neovascularization
• 발행기관: 대한안과학회
• 저자명: 유은석 이동원,Eun Seok Yoo, MD, Dong Won Lee, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume52,number4, 442~447쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.04.15

영문 초록

Purpose: To presents the effect of triple therapy including C3F8 gas injection, intravitreal anti-VEGF injection and photodynamic therapy on patients with subretinal hemorrhage accompanied by choroidal neovascularization. Methods: Twelve eyes of 12 patients suffering from subretinal hemorrhage accompanied by choroidal neovascularization with onset of the symptom within a week prior to three-day prone positioning after C3F8 gas injection were included in the present study. Next, intravitreal anti-VEGF injection and photodynamic therapy was performed. Then, within two months, intravitreal bevacizumab or ranibizumab injection was performed. Results: After stabilization of the submacular hemorrhagic lesion, ten eyes of ten patients showed improved visual acuity, one eye showed no improvement, and decreased visual acuity developed in one patient. LogMAR visual acuity improved after the initial treatment from 1.05 ± 0.43 to 0.74 ± 0.58 and 0.53 ± 0.51 at three and six months, respectively. The improvement was considered to be clinically significant. Conclusions: An appropriate regimen for treating broad submacular hemorrhage accompanied by choroidal neovascularization has not been established. The authors of the patients had obtained positive results from C3F8 gas injection, intravitreal anti-VEGF injection and photodynamic therapy. In the future, additional studies should be conducted. J Korean Ophthalmol Soc 2011;52(4):442-447

키워드

Anti-VEGF injection, CNV (Choroidal neovascularization), Gas injection, PDT (photodynamic therapy), Subretinal hemorrhage