아포지단백 E 유전자 변이와 백내장의 관련성

• 영문명: An Association Study of Apolipoprotein E Gene Polymorphism and Cataracts
• 발행기관: 대한안과학회
• 저자명: 지미정 임정수 백혜정,Mijung Chi, MD, PhD, Jung Soo Im, MD, PhD, Hae Jung Paik, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume52,number4, 420~428쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.04.15

영문 초록

Purpose: To evaluate the association of apolipoprotein E (APOE) polymorphism and cataracts in the Korean population. Methods: The present research included participants from a population-based study in Incheon, Korea. A sample of 126 adults genotyped for polymorphisms of APOE underwent a medical interview, an eye examination which included visual acuity testing, slitlamp cataract evaluation and fundus examination. The APOE polymorphism was determined using a polymerase chain reaction method. Results: Eighty-eight participants (69.8%) were diagnosed with cataracts or had undergone cataract surgery in 1 or both eyes, and 38 participants (30.2%) demonstrated no signs of cataract. The frequencies of the APOE genotypes and alleles were not significantly different from the cataract and the control group. APOE ε2 carriers were less likely to have cataracts than non-ε2 carriers with an odds ratio of 0.367 which was almost statistically significant with the multiple logistic regression analysis (p = 0.052). Conclusions: There was no significant correlation of APOE genotype and cataracts. However, a slight negative association of APOE ε2 and cataracts were found in the Korean population. J Korean Ophthalmol Soc 2011;52(4):420-428

키워드

Apolipoprotein E, Cataract, Gene polymorphism