눈부속기를 침범한 Hyper-IgG4 증후군 3예

• 영문명: Three Cases of Hyper-IgG4 Syndrome Involving Ocular Adnexa
• 발행기관: 대한안과학회
• 저자명: 김고은 이민정 김남주 정호경 곽상인,KoEun Kim, MD, Min Joung Lee, MD, Nam Ju Kim, MD,, Ho-Kyung Choung, MD,, Sang In Khwarg, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number8, 1133~1138쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.08.15

영문 초록

Purpose: To report 3 cases of hyper-IgG4 syndrome involving ocular adnexa. Case summary: A 66-year-old woman presented with swelling of the bilateral upper eyelids with ocular pain that began 1 year before. Nodular episcleral injection of the left eye and other generalized symptoms, such as cough, decreased hearing ability, multiple nodular lesions of the bilateral lungs and right kidney, together suggested rheumatic disease. Orbital computed tomographic images revealed diffuse swelling of the bilateral lacrimal glands. After immunostaining a surgically- biopsied specimen from the lacrimal gland for IgG4 expression, 15% of infiltrated lymphoplasmacytic cells were IgG4-positive. Similar findings were shown with biopsied specimens from the lung and kidney; therefore, the patient was diagnosed with Hyper-IgG4 syndrome. A 49-year-old woman complained of a mass in the left upper eyelid that began 4 years earlier. Orbital computed tomographic images showed a 5-mm-sized mass in the left upper eyelid. Ocular adnexal Hyper-IgG4 syndrome was confirmed by the immunostained biopsy from the left upper eyelid, showing infiltration of IgG4-positive lymphoplasmacytic cells. A 51-year-old woman presented with swelling of the bilateral lacrimal glands. Enlargement of the bilateral lacrimal glands were apparent in orbital computed tomographic images. After anti-IgG4 antibody staining of a biopsied specimen from the right lacrimal gland, dense infiltration of IgG4-positive lymphoplasmacytic cells was observed. The patient was also diagnosed with Hyper-IgG4 syndrome. J Korean Ophthalmol Soc 2010;51(8):1133-1138

키워드

Autoimmune pancreatitis, Hyper-IgG4 syndrome, IgG4-positive lymphoplasmacytic cells, Lacrimal gland,