중증 건성안에서 헤파린과 인지질을 사용한 복합치료의 임상적 효과

• 영문명: Clinical Effects of Combination Therapy Using Heparin and Phospholipid in Severe Dry Eye Syndrome
• 발행기관: 대한안과학회
• 저자명: 주광식 전연숙 김재찬,Kwang Sic Joo, MD, Yeoun Sook Chun, MD, PhD, Jae Chan Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number8, 1047~1053쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.08.15

영문 초록

Purpose: To evaluate the therapeutic effects of topical heparin (Hylo-ParinⓇ, Ursapharm Saarbr cken, Germany) and spray type phospholipids (Tears AgainⓇ, Optima Pharmazeutische GmbH. Freising, Germany) in severe dry eye syndrome resistant to conventional therapy. Methods: Twenty eyes of ten patients with refractory severe dry eye were treated with Hylo-ParinⓇ (two times a day) and Tears AgainⓇ (three times a day) for three months. Before and one and three months after treatment, a symptom questionnaire was administered to the patients. The ocular surface disease index (OSDI), tear film break-up time, Schirmer test, conjunctival fluorescein staining examinations and filamentary keratitis were evaluated. Results: After using Tears AgainⓇ and Hylo-ParinⓇ, the OSDI score improved from 64.13 ± 15.12 to 43.80 ± 15.87 (p＜0.01). Tear film break-up time significantly increased from 1.0 ± 0.65 to 2.3 ± 0.73 seconds (p＜0.01) and conjunctival staining score (Oxford scale) significantly decreased from 3.85 ± 0.75 to 3.25 ± 0.97 (p＜0.01). Filamentary keratitis in the slit-lamp examination showed significant improvement (p＜0.01). Conclusions: Tears AgainⓇ and Hylo-ParinⓇ are considered as new treatment modalities for severe dry eye syndrome and filamentary keratitis in patients with chronic ocular surface disease resistant to conventional therapy. These treatments require additional research. J Korean Ophthalmol Soc 2010;51(8):1047-1053

키워드

Dry eye, Filamentary keratitis, Heparin, Liposome, Phospholipid