토끼에서 녹내장 여과수술 후 저농도 사이클로스포린이 창상치유에 미치는 영향

• 영문명: Glaucoma Filtering Surgery With Low Concentration of Cyclosporin A in Rabbits: A Pilot Study
• 발행기관: 대한안과학회
• 저자명: 김연덕 황형빈 박명희 문정일,Yeon-Deok Kim, MD,, Hyung Bin Hwang, MD, Myoung Hee Park, MD, PhD, Jung Il Moon, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number5, 740~745쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.05.15

영문 초록

Purpose: The effect of 0.2% cyclosporin A (CsA) as an adjuvant therapy after glaucoma-filtering surgery was the focus of this study. Methods: A posterior lip sclerotomy was performed in 16 eyes of 8 rabbits, and 0.2% CsA was administered into the right eyes. The left eyes served as controls. The intraocular pressure (IOP) was measured 1, 3, 5, 7, 14, and 28 days after surgery. Hematoxylin-eosin (HE) and anti-bromodeoxyuridine (BrdU) immunocytochemical staining were performed at 1, 2, 4, and 8 weeks. Results: The IOP at 7 and 14 days after surgery was lower in the 0.2% CsA group and statistically significant (P=0.047, P=0.48; respectively). HE staining did not show any difference between experimental and control eyes, but anti-BrdU staining showed a lower number of positive cells in the experimental eyes at 1 week. The fibroblast proliferation rate was significantly lower 1 week after surgery in the 0.2% CsA group (P=0.003). Conclusions: An effect of 0.2% CsA on early wound healing was observed. The data suggest that a low concentration of CsA can be useful when employed as adjuvant therapy in glaucoma filtering surgery. J Korean Ophthalmol Soc 2010;51(5):740-745

키워드

Adjuvant therapy, Antifibrotic agent, Cyclosporin, Glaucoma filtering surgery, Wound healing