유리체강 내 베바시주맙이 각막내피세포에 미치는 영향

• 영문명: Corneal Endothelial Change After Intravitreal Bevacizumab Injection
• 발행기관: 대한안과학회
• 저자명: 서소연 이정희 전루민,Soh-youn Suh, MD, Jeong-hee Lee, MD, PhD, Roo Min Jun, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number12, 1549~1553쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.12.15

영문 초록

Purpose: To evaluate the in vivo corneal endothelial changes after intravitreal bevacizumab (Avastin®; Genentech Inc., San Francisco, California, USA) injection. Methods: A total of 30 eyes of 28 patients who received intravitreal bevacizumab injections were included in the present study. Before injection and one and three months after injection, specular microscopy was performed to analyze the corneal endothelial cell changes. In order to compare the differences in the changes of corneal endothelial cells, the eyes were divided into two groups, a single injection group and a multiple injection group. Results: The mean endothelial cell count decreased from 2,497.4 ± 427.8 at baseline to 2,421.2 ± 430.5 at one month and to 2,362.7 ± 366.2 at three months after the injection in all patients. However, the change in endothelial cell count was not statistically significant. In addition, the postoperative change in endothelial cell count was more prominent in the multiple injection group than in the single injection group, although the difference was again not significant. No significant changes in preoperative or postoperative coefficients of variation for cell area or hexagonalities were observed in either patient group or within each group. Conclusions: There was no significant change in corneal endothelial cells after intravitreal bevacizumab injection. In addition, there was no significant difference in the changes in corneal endothelial cells according to the number of bevacizumab injections. J Korean Ophthalmol Soc 2010;51(12):1549-1553

키워드

Bevacizumab, Cornea, Cytotoxicity, Endothelium, Specular microscopy