황반원공과 당뇨황반부종에서 술 중 제거한 내경계막의 미세구조

• 영문명: Ultrastructure of the Internal Limiting Membrane Removed During Macular Hole and Diabetic Macular Edema Surgery
• 발행기관: 대한안과학회
• 저자명: 구기홍 이지은 최희영 엄부섭,Gi Hong Koo, MD, Ji Eun Lee, MD, PhD,, Hee Young Choi, MD, PhD,, Boo Sup Oum, MD, PhD,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number1, 42~48쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.01.15

영문 초록

Purpose: To evaluate retinal damage following internal limiting membrane (ILM) peeling in macular hole and diabetic macular edema (DME) surgeries. Methods: Forty-five eyes with macular holes and thirty-five eyes with DME underwent pars plana vitrectomy with ILM peeling. The structures of the ILM were investigated using transmission electron microscopy, and the grades of retinal tissue damage were analyzed. We additionally observed the clinicopathologic association of retinal damage with the development of retinal hemorrhage during ILM peeling and that seen with indocyanine green (ICG) staining. Results: In all specimens, cellular fragments were observed on the retinal side of the ILM in both macular hole and DME patients. The thickness of the ILM in DME significantly increased (3.13±1.12 μm compared with that in patients with macular holes (2.41±0.77 μm, p=0.002). The frequency of minute retinal bleeding during ILM peeling was higher in macular hole patients (46.7%) than in those with diabetic macular edema (22.9%m p=0.028). Twenty-two eyes of 45 macular hole patients (48.9%) and 16 eyes of 35 DME patients (45.7%) had relative retinal damage. Overall, ILM performed in eyes which had minute bleeding during the peeling had more retinal damage (62.1%) than did those without hemorrhage (39.2%, p=0.049). ICG staining did not appear to influence retinal damage (p=0.81). Conclusions: ILM peeling can cause minor, but demonstrable, damage of the adjacent retina. J Korean Ophthalmol Soc 2010;51(1):42-48

키워드

Internal limiting membrane, Mü ller cell