프로스타글란딘 제제의 장기 점안이 각막두께에 미치는 영향

• 영문명: The Effects of Prostaglandin Analogues on the Corneal Thickness
• 발행기관: 대한안과학회
• 저자명: 박명희 조경진 문정일,Myoung Hee Park, MD, Kyongjin Cho MD, Jung-Il Moon, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number4, 565~571쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.04.30

영문 초록

Purpose: To evaluate the effects of prostaglandin analogues on the corneal thickness of patients with primary open-angle glaucoma (POAG) or normal tension glaucoma (NTG). Methods: This study included 130 eyes of 65 patients who were diagnosed with POAG or NTG. All patients were divided into two groups; one group received prostaglandin analogues, while the other group received alternative ocular hypotensive eyedrops. Corneal thickness, best corrected visual acuity, and flare in the anterior chamber were measured and compared before treatment and at least 24 months (mean: 27 months) after treatment. Results: The mean decrease in corneal thickness was statistically significant in the group using prostaglandin analogues, but not in the control group. Among the various prostaglandin analogues used, travoprost and latanoprost decreased mean corneal thickness, but bimatoprost had no effect. Best corrected visual acuity, refraction power, and flare in the anterior chamber did not change significantly in either group of patients when ocular hypotensive eyedrops were used. Conclusions: Prostaglandin analogues lower intraocular pressure and decrease corneal thickness if used over a 24 months. J Korean Ophthalmol Soc 2009;50(4):565-571

키워드

Corneal thickness, Prostaglandin analogue