나이관련 황반변성의 맥락막신생혈관에서 베바시주맙 유리체강내 주입술 효과와 예후인자

• 영문명: Effects and Prognostic Factors of Intravitreal Bevacizumab Injection on Choroidal Neovascularization from Age-Related Macular Degeneration
• 발행기관: 대한안과학회
• 저자명: 오세범 조원빈 문준웅 김형찬,Se Beum Oh, MD, Won Bin Cho, MD, Jun Woong Moon, MD, Hyung Chan Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number2, 202~210쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.02.15

영문 초록

Purpose: To investigate the effects and prognostic factors related to intravitreal injection of bevacizumab on patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration. Methods: The medical records of patients who received 3 consecutive intravitreal injections of bevacizumab (1.25 mg/0.05 ml, 6 weeks interval) for subfoveal choroidal neovascularization secondary to age-related macular degeneration and followed up for more than 12 months were reviewed (a total of 31 eyes; male, 20; mean age, 72.3±7.5 years). Baseline best corrected visual acuity, foveal thickness, and total macular volume were compared with those after 1, 4, and 12 months. The therapeutic effects were investigated with regard to factors such as age, sex, initial visual acuity, lesion size, subtypes of choroidal neovascularization, pigment epithelial detachment, submacular hemorrhage, and previous history of photodynamic therapy. Results: Initial visual acuity (logMAR), foveal thickness, and total macular volume were 0.74±0.49, 320±88 μm and 9.50±2.99 mm3, respectively. Visual acuity improved to 0.68±0.61 (p=0.012), and foveal thickness and total macular volume decreased to 218±69 μm and 6.32±0.71 mm3 (p<0.001), respectively, at 12 months. Visual improvement was achieved less often in patients who were 75 years or older and who had lesions 3 disc areas or greater and relatively good initial vision at 12 months. Conclusions: Intravitreal bevacizumab injection has beneficial effects for patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration with regard to function and anatomy. However, it should be noted that visual improvement may be limited in older patients with larger lesions and good initial vision.

키워드

Age-related macular degeneration, Choroidal neovascularization, Intravitreal bevacizumab injection