건성안이 있는 이식편대숙주질환에서 사이클로스포린 A 점안치료 후 장기간의 경과관찰

• 영문명: Long-term Evaluation After Topical Cyclosporine Treatment in Dry Eye Patients With Graft-Versus-Host Disease
• 발행기관: 대한안과학회
• 저자명: 이승현 임성규 우제문 윤경철,Seung Hyun Lee, MD, Seoung Kyu Im, MD, Je-Moon Woo, MD, PhD, Kyung Chul Yoon, MD. PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number1, 27~33쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.01.15

영문 초록

Purpose: This study was performed to evaluate the long-term effect of 0.05% cyclosporine A emulsion (Restasis, Allergan Inc. USA.) on dry eye associated with graft-versus-host disease (GVHD). Methods: Sixteen eyes of 8 patients with severe dry eye associated with GVHD were treated with 0.05% cyclosporine A emulsion twice a day. Tear film parameters were evaluated before treatment and after 1, 3, 6, and 12 months of treatment. Results: One month after treatment, tear break-up time improved from 3.88±1.78 s to 4.17±1.90 s (P=0.02). Three months after treatment, symptom score and basal secretion improved from 3.00±0.38 and 4.44±1.59 mm to 2.33±0.52 (P=0.04) and 5.42±2.50 mm (P=0.04), respectively. Twelve months after treatment, the keratoepitheliopathy score improved from 2.38±1.31 to 1.13±0.35 (P=0.02). Conclusions: Use of a 0.05% cyclosporine A emulsion is effective for dry eye associated with GVHD as it helps to increase tear secretion and to relieve symptoms. Treatment with 0.05% cyclosporine A emulsion for longer than 1 year may be necessary to improve keratoepitheliopathy.

키워드

Cyclosporine, Dry eye syndrome, Graft-versus-host disease