가토에서 히알루론산나트륨과 카르복시메틸셀룰로오스나트륨 혼합액이 술 후 유착에 미치는 영향

• 영문명: Antiadhesive Effect of the Mixed Solution of Hyaluronate and Sodium Carboxymethylcellulose After Strabismus Surgery
• 발행기관: 대한안과학회
• 저자명: 권성욱 서영우 조윤애,Sung Wook Kwon, MD, Young Woo Seo, MD, Yoonae A. Cho, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number1, 145~150쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.01.15

영문 초록

Purpose: To evaluate the effect of the mixed solution of hyaluronate and sodium carboxymethylcellulose (HACMC, Guardix-sol®) in reducing postoperative adhesion following strabismus surgery. Methods: In 16 rabbits out of 20 rabbits, 3 mm recession of the superior rectus muscle was performed on both eyes and HACMC solution was applied only to one eye which was randomly chosen. The rabbits were divided into a surgery-HACMC group and a surgery-no HACMC group. As a control group, the remaining 4 rabbits had no procedures performed. After 3 weeks, both eyes of 8 rabbits with surgery and 2 rabbits of the control group were enucleated. After staining with hematoxylin-eosin and Masson\'s trichrome, a histologic examination was performed. In the remaining 10 rabbits, the severity of adhesion in muscle and adjacent tissues was observed by blunt dissection. A researcher blind to the experiments performed all the examinations. Results: A significant reduction in the degree of adhesion (P=0.005) as well as decreased fibrosis (P=0.015) was observed in the surgery-HACMC group. Conclusions: The mixed solution of HACMC was effective in reducing postoperative adhesion after strabismus surgery in rabbits.

키워드

Adehesion, Sodium carboxymethylcellulose, Sodium hyaluronate, Strabismus surgery