여과포 실패 예방 목적으로 베바시주맙 결막하 주사를 이용한 섬유주절제술 2예

• 영문명: Two Cases of Subconjunctival Bevacizumab Injection to Prevent Bleb Failure After Trabeculectomy
• 발행기관: 대한안과학회
• 저자명: 이동욱 이대규,Dong Wook Lee, M.D., Dae-Gyu Lee, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume49,number8, 1345~1349쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.08.15

영문 초록

Purpose: Angiogenesis is an integral part of wound healing, which is an unwanted process in the postoperative period after trabeculectomy. It was the aim of this study to report on the subconjunctival use of bevacizumab (Avastin®) as an antiproliferative agent to augment trabeculectomy. Case summary: This clinical interventional case study included 2 patients with secondary glaucoma associated with uveitis who underwent antiglaucomatous filtering surgery combined with a subconjunctival injection of bevacizumab. Limbal-based trabeculectomy was performed, and subconjunctival injections (1.25 mg/0.05 ml) were given at the end of the surgery adjacent to the bleb, which was raised using a single-use 26 gauge needle. At 1 and 2 weeks and 1, 3, and 6 months after surgery, intraocular pressure was reduced in both patients to 11 mmHg with functioning filtering blebs. No complications were observed. Conclusions: The results suggest that subconjunctival bevacizumab injection may be helpful in reducing the risk of postoperative scarring of the filtering bleb. J Korean Ophthalmol Soc 49(8):1345-1349, 2008

키워드

Bevacizumab (Avastin® ), Subconjunctival injection, Trabeculectomy