재발성군날개 치료에 있어 항혈관내피성장인자 항체 베바시주맙을 적용한 임상효과

• 영문명: Clinical Results After Application of Bevacizumab in Recurrent Pterygium
• 발행기관: 대한안과학회
• 저자명: 이종욱 박영정 김인택 이규원,Jong Wook Lee, M.D., Young Jeung Park, M.D., In Taek Kim, M.D., Kyoo Won Lee, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume49,number12, 1901~1909쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.12.15

영문 초록

Purpose: To clinically establish the effectiveness and safety of bevacizumab on recurrent pterygium. Methods: Twenty patients with recurrent pterygium were given a subconjunctival injection of 0.3 cc bevacizumab, and were evaluated for periodic clinical results at 1 week, 2 weeks, 4 weeks, and every month thereafter. The patients were also evaluated for clinical results and complications. Results: Of recurrent pterygium patients with bevacizumab injection, the conjunctival injection decreased maximally after 1 to 2 weeks, but significantly increased at 4 weeks (above the lowest level measured at 1 to 2 weeks), and no patient presented conjunctival injection above the pre-injection level at 3 months, except in 2 cases. Two weeks after the injection, ICG anterior segment angiography revealed a significant decrease (30.14+17.69%) in vessel thickness of the pterygium 2 weeks after the bevacizumab injection compared to before the injection. There had been no cases of progression of pterygium, and no ocular or systemic complications due to bevacizumab. Conclusions: As shown above in the results, subconjunctival injection of 0.3 cc bevacizumab decreased the conjunctival injection and effectively suppressed any further progression of pterygium. Thus, bevacizumab subconjunctival injection appears to be effective in recurrent pterygium treatment instead of surgical methods.

키워드

Bevacizumab, Recurrent pterygium, Subconjunctival injection