한국인 단순포진각막염 환자의 임상 분석

• 영문명: Clinical Analysis of Herpetic Keratitis in Korea
• 발행기관: 대한안과학회
• 저자명: 황준서 위원량 이진학 김미금,Joon Seo Hwang, M.D.,, Won Ryang Wee, M.D.,, Jin Hak Lee, M.D.,, Mee Kum Kim, M.D.,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume48,number9, 1212~1219쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.09.30

영문 초록

Purpose: To investigate the clinical characteristics of herpetic keratitis in Korea. Methods: A retrospective analysis was performed on 90 eyes of 84 patients who were clinically diagnosed with herpetic keratitis and were followed for at least 4 months or more. Information on prior herpetic keratitis, type of keratitis, time to remission, recurrence rate, administration of oral acyclovir, final visual acuity was reviewed. Remission time and recurrence rate were compared according to types of herpetic keratitis and the application of oral acyclovir in epithelial, stromal or endothelial keratitis; and the relation of history of previous herpetic keratitis, recurrence and final vision, was analyzed. Results: Sex ratio (M:F) was 1.31 and the mean age was 54.6 years. Of 90 eyes, the proportion of infectious epithelial keratitis, stromal keratitis, endothelitis and neurotrophic ulcer was 51.1, 17.8, 25.6 and 5.6%, respectively. The mean remission time was 1.92±1.01, 4.13±5.05, 5.52±5.08, 4.00±1.00, respectively (p=0.001, one-way Anova). Recurrence occurred in 21 (42.9%) eyes of 49, which were followed up for more than 12 months, in a year after the previous attack. The rates of recurrence of infectious epithelial keratitis, stromal keratitis and endothelitis were 25.0%, 63.6% and 53.8%, respectively. Oral acyclovir neither shortens the remission nor prevents the recurrence. The percentage of final vision over 20/40 in infectious epithelial keratitis, stromal keratitis and endothelitis was 81.1, 57.1 and 60.0%, respectively. The final vision was worse in the group with a history of herpetic keratitis. Conclusions: Stromal keratitis and endothelitis showed a higher recurrence rate and longer remission time than infectious epithelial keratitis. Because recurrent and severe keratitis may result in corneal opacity and vision loss, aggressive and proper treatment is needed. However, these cases are often resistant to therapy.

키워드

Herpes simplex keratitis, Oral acyclovir, Recurrence, Visual loss, Stromal keratitis