실험적으로 유도된 당뇨유발 쥐 망막에서 리포산에 의한 혈관내피성장인자와 STAT3 억제효과

• 영문명: Suppression of VEGF and STAT3 by Lipoic acid in Experimental Diabetic Rat Retina
• 발행기관: 대한안과학회
• 저자명: 유선임 정희정 허대영 김현웅 윤일한,Sun Im Yu, M.D., Hee Jung Jung, M.D., Dae Young Her, M.D., Hyun Woong Kim, M.D., Il Han Yun, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume48,number5, 715~724쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.05.31

영문 초록

Purpose: We evaluated whether lipoic acid as antioxidant could inhibit expression of VEGF and STAT3 in experimental diabetic rat retina. Methods: Diabetes was induced chemically by injection of streptozotocin in 12 rats of 18 Sprague-Dawley rats. After induction of diabetes, lipoic acid was injected into the peritonium in 6 rats. So all rats were divided into 3 groups, normal group (n=6), diabetes mellitus (DM) group (n=6), lipoic acid treated group (n=6). The ocular tissue of the rats were collected on 8 weeks after diabetes induction. Difference of VEGF and STAT3 expression was investigated by immunohistochemistry, RT-PCR, western blot. The change of VEGF and STAT3 in lipoic acid treated group were evaluated in these experimental model. Results: The VEGF and STAT3 expression was elevated in diabetic rat retina. The active form STAT3, phosphorylated STAT3 was also elevated. The VEGF and STAT3 expression in lipoic acid treated group was lower than DM group. Conclusions: The lipoic acid could inhibit the VEGF and STAT3 expression in diabetic rat retina.

키워드

Diabetic retinopathy, Lipoic acid, STAT3, VEGF